Quantitative real-time PCR detection of insulin signalling-related genes in pancreatic islets isolated from healthy cats

Veterinary Journal

Volumn 183, Issue 3, 2010, Pages 287-293

  Zini, Eric ^a   Franchini, Marco ^a   Osto, Melania ^a   Vögtlin, Andrea ^a   Guscetti, Franco ^a   Linscheid, Philippe ^a   Kaufmann, Karin ^a   Sigrist, Brigitte ^a   Ackermann, Mathias ^a   Lutz, Thomas A ^a   Reusch, Claudia E ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cell; Diabetes; Feline; mRNA; Transcript

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; GLUCOSE TRANSPORTER 2; INSULIN; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR PDX 1;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAT; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; FEASIBILITY STUDY; GENE SEQUENCE; GENETIC TRANSCRIPTION; ISOLATED PANCREAS ISLET; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY; SIGNAL TRANSDUCTION;

ANIMALS; CASPASE 8; CATS; CHEMOKINE CCL2; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; INTERLEUKIN-8; ISLETS OF LANGERHANS; MALE; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

CANIS FAMILIARIS; FELIDAE; RATTUS;

EID: 75849154498     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2008.11.012     Document Type: Article

References (25)

1. Appleton D.J., Rand J.S., and Sunvold G.D. Insulin sensitivity decreases with obesity, and lean cats with low insulin sensitivity are at greatest risk of glucose intolerance with weight gain. Journal of Feline Medicine and Surgery 3 (2001) 211-228
2. Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., and Butler P.C. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52 (2003) 102-110
3. Chankiewitz E., Peschke D., Herberg L., Bazwinsky I., Mühlbauer E., Brömme H.J., and Peschke E. Did the gradual loss of GLUT2 cause a shift to diabetic disorders in the New Zealand obese mouse (NZO/Hl)?. Experimental and Clinical Endocrinology and Diabetes 114 (2006) 262-269
4. Donath M.Y., Gross D.J., Cerasi E., and Kaiser N. Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes 48 (1999) 738-744
5. Ehses J.A., Perren A., Eppler E., Ribaux P., Pospisilik J.A., Maor-Cahn R., Gueripel X., Ellingsgaard H., Schneider M.K., Biollaz G., Fontana A., Reinecke M., Homo-Delarche F., and Donath M.Y. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes 56 (2007) 2356-2370
6. Henson M.S., and O'Brien T.D. Feline models of type 2 diabetes mellitus. ILAR Journal 47 (2006) 234-242
7. Johnson J.H., Ogawa A., Chen L., Orci L., Newgard C.B., Alam T., and Unger R.H. Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. Science 250 (1990) 546-549
8. Kipar A., Leutenegger C.M., Hetzel U., Akens M.K., Mislin C.N., Reinacher M., and Lutz H. Cytokine mRNA levels in isolated feline monocytes. Veterinary Immunology and Immunopathology 78 (2001) 305-315
9. Linsenmeier R.A., Braun R.D., McRipley M.A., Padnick L.B., Ahmed J., Hatchell D.L., McLeod D.S., and Lutty G.A. Retinal hypoxia in long-term diabetic cats. Investigative Ophthalmology and Visual Science 39 (1998) 1647-1657
10. Lutz T.A., and Rand J.S. Pathogenesis of feline diabetes mellitus. Veterinary Clinics of North America Small Animal Practice 25 (1995) 527-552
11. Lutz T.A., and Rand J.S. Detection of amyloid deposition in various regions of the feline pancreas by different staining techniques. Journal of Comparative Pathology 116 (1997) 157-170
12. Maedler K., and Donath M.Y. Beta-cells in type 2 diabetes: a loss of function and mass. Hormone Research 62 Suppl. 3 (2004) 67-73
13. Maedler K., Spinas G.A., Lehmann R., Sergeev P., Weber M., Fontana A., Kaiser N., and Donath M.Y. Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes 50 (2001) 1683-1690
14. Maedler K., Sergeev P., Ris F., Oberholzer J., Joller-Jemelka H.I., Spinas G.A., Kaiser N., Halban P.A., and Donath M.Y. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. Journal of Clinical Investigation 110 (2002) 851-860
15. Maedler K., Fontana A., Ris F., Sergeev P., Toso C., Oberholzer J., Lehmann R., Bachmann F., Tasinato A., Spinas G.A., Halban P.A., and Donath M.Y. FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication. Proceedings of the National Academy of Science USA 99 (2002) 8236-8241
16. Maeno T., Inoue M., Embabi S.N., Miki D., and Hatchell D.L. Islet-like cell clusters: viability, cell types, and subretinal transplantation in pancreatectomized cats. Laboratory Animals 40 (2006) 432-446
17. Marshak S., Leibowitz G., Bertuzzi F., Socci C., Kaiser N., Gross D.J., Cerasi E., and Melloul D. Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose. Diabetes 48 (1999) 1230-1236
18. Mizisin A.P., Shelton G.D., Burgers M.L., Powell H.C., and Cuddon P.A. Neurological complications associated with spontaneously occurring feline diabetes mellitus. Journal of Neuropathology and Experimental Neurology 61 (2002) 872-884
19. Rand J.S., Fleeman L.M., Farrow H.A., Appleton D.J., and Lederer R. Canine and feline diabetes mellitus: nature or nurture?. Journal of Nutrition 134 Suppl. 8 (2004) 2072-2080
20. Roche E., Assimacopoulos-Jeannet F., Witters L.A., Perruchoud B., Yaney G., Corkey B., Asfari M., and Prentki M. Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1). Journal of Biological Chemistry 272 (1997) 3091-3098
21. Rodriguez-Mulero S., and Montanya E. Selection of a suitable internal control gene for expression studies in pancreatic islet grafts. Transplantation 80 (2005) 650-652
22. Seufert J., Weir G.C., and Habener J.F. Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus. Journal of Clinical Investigation 101 (1998) 2528-2539
23. Waeber G., Thompson N., Nicod P., and Bonny C. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Molecular Endocrinology 10 (1996) 1327-1334
24. Yoon K.H., Ko S.H., Cho J.H., Lee J.M., Ahn Y.B., Song K.H., Yoo S.J., Kang M.I., Cha B.Y., Lee K.W., Son H.Y., Kang S.K., Kim H.S., Lee I.K., and Bonner-Weir S. Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. Journal of Clinical Endocrinology and Metabolism 88 (2003) 2300-2308
25. Zini, E., Osto, M., Franchini, M., Guscetti, F., Donath, M.Y., Perren, A., Heller, R.S., Linscheid, P., Bouwman, M., Ackermann, M., Lutz, T.A., Reusch, C.E. (in press). Hyperglycaemia but not hyperlipidaemia causes beta-cell dysfunction and beta-cell loss in the domestic cat. Diabetologia.