Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels

European Journal of Medicinal Chemistry

Volumn 35, Issue 1, 2000, Pages 147-156

  Duranti, Andrea ^a   Franchini, Carlo ^b   Lentini, Giovanni ^b   Loiodice, Fulvio ^b   Tortorella, Vincenzo ^b   De Luca, Annamaria ^b   Pierno, Sabata ^b   Conte Camerino, Diana ^b  

^a UNIVERSITY OF URBINO   (Italy)

^b Via Edoardo O   (Italy)

Author keywords

Antiarrhythmic drug; Chiral analogues; Mexiletine; Myotonia; Sodium channel tonic block; Sodium channel use dependent block

Indexed keywords

3 (2,6 DIMETHYLPHENOXY) 2 METHYL 1 PROPANAMINE; ANTIARRHYTHMIC AGENT; MEXILETINE; SODIUM CHANNEL; TOCAINIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; FROG; ISOMERISM; MUSCLE CELL; MYOTONIA; NONHUMAN; PHENOTYPE; SKELETAL MUSCLE; SODIUM CURRENT; STEREOCHEMISTRY;

EID: 0034009097     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)00115-X     Document Type: Article

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