Pharmacokinetics and efficacy of intravenous and extradural tramadol in dogs

Veterinary Journal

Volumn 183, Issue 3, 2010, Pages 310-315

  Vettorato, Enzo ^a   Zonca, Annalisa ^b   Isola, Maurizio ^a   Villa, Roberto ^b   Gallo, Martina ^b   Ravasio, Giuliano ^b   Beccaglia, Michela ^b   Montesissa, Clara ^a   Cagnardi, Petra ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Dog; Efficacy; Extradural; Pharmacokinetics; Tramadol

Indexed keywords

ALTADOL; DRUG METABOLITE; O NORTRAMADOL; TRAMADOL; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DOG; DRUG ABSORPTION; DRUG CLEARANCE; DRUG EFFICACY; FEMALE; MALE; MEAN RESIDENCE TIME; NONHUMAN; OSTEOTOMY; PAIN ASSESSMENT; PATIENT MONITORING; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN;

ANALGESICS, OPIOID; ANIMALS; AREA UNDER CURVE; DOGS; FEMALE; INJECTIONS, EPIDURAL; INJECTIONS, INTRAVENOUS; MALE; PAIN, POSTOPERATIVE; TRAMADOL; TREATMENT OUTCOME;

CANIS FAMILIARIS;

EID: 75849125636     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2008.11.002     Document Type: Article

References (49)

1. Baraka A., Jabbour S., Ghabash M., Nader A., Khoury G., and Sibai A. A comparison of epidural tramadol and epidural morphine for post-operative analgesia. Canadian Journal of Anaesthesia 40 (1993) 308-313
2. Bozkurt P. Use of tramadol in children. Pediatric Anaesthesia 15 (2005) 1041-1047
3. Buback J.L., Boothe H.W., Carroll G.L., and Green R.W. Comparison of three methods for relief of pain after ear canal ablation in dogs. Veterinary Surgery 25 (1996) 380-385
4. Cagnardi P., Zonca A., Carli S., Fonda D., Ravasio G., and Villa R. Pharmacokinetics of tramadol in cats undergoing neutering. Journal of Veterinary Pharmacology and Therapeutics 29 Suppl. 1 (2006) 289-290
5. Conzemius M.G., Hill C.M., Sammarco J.L., and Perkowski S.Z. Correlation between subjective and objective measures used to determine severity of post-operative pain in dogs. Journal of the American Veterinary Medical Association 210 (1997) 1619-1622
6. De Sousa A.B., Santos A.C.D., Schramm S.G., Porta V., Gorniak S.L., Florio J.C., and De Sousa Spinosa H. Pharmacokinetics of tramadol and O-desmethyl tramadol in goats after intravenous and oral administration. Journal of Veterinary Pharmacology and Therapeutics 31 (2008) 45-51
7. Delilkan A.E., and Vijayan R. Epidural tramadol for post-operative pain relief. Anaesthesia 48 (1993) 328-331
8. Demiraran Y., Kocaman B., and Akman R.Y. A comparison of the post-operative analgesic efficacy of single-dose epidural tramadol versus morphine in children. British Journal of Anaesthesia 95 (2005) 510-513
9. Desmeules J.A., Piguet F., Collart L., and Dayer P. Contribution of monoaminergic modulation on the analgesic effect of tramadol. British Journal of Clinical Pharmacology 41 (1996) 7-12
10. Firth A.M., and Haldane S.L. Development of a scale to evaluate post-operative pain in dog. Journal of the American Veterinary Medical Association 214 (1999) 651-659
11. Gibaldi M., and Perrier D. Pharmacokinetics (1982), Marcel Dekker Inc., New York
12. Gillen C., Haurand M., Kobelt D.J., and Wnendt D. Affinity potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor. Naunyn-Schmiedeberg's Archives of Pharmacology 362 (2000) 116-121
13. Grisneaux E., Pibarot P., Dupuis J., and Blais D. Comparison of ketoprofen and carprofen administered prior to orthopedic surgery for control of post-operative pain in dogs. Journal of the American Veterinary Medical Association 215 (1999) 1105-1110
14. Grond S., and Sablotzki A. Clinical pharmacology of tramadol. Clinical Pharmacokinetics 43 (2004) 879-923
15. Güneş Y., Güundüz M., Ünlu{combining double acute accent}genç H., Özalevli M., and Özcengiz D. Comparison of caudal vs. intravenous tramadol administered either pre-operatively or post-operatively for pain relief in boys. Pediatric Anaesthesia 14 (2004) 324-328
16. Heard D.J., Webb A.I., and Daniels R.T. Effect of acepromazine on the anesthetic requirement of halothane in the dog. American Journal of Veterinary Research 44 (1986) 2113-2115
17. Holton L.L., Scott E.M., Nolan A.M., Reid J., Welsh E., and Flaherty D. Comparison of three methods used for assessment of pain in dogs. Journal of the American Veterinary Medical Association 212 (1998) 61-66
18. Kukanich B., and Papich M.G. Pharmacokinetics of tramadol and the metabolite O-desmethyl tramadol in dogs. Journal of Veterinary Pharmacology and Therapeutics 27 (2004) 239-246
19. Lam F.C., Hung C.T., and Perrier D.G. Estimation of variance for harmonic mean half-lives. Journal of Pharmaceutical Sciences 74 (1985) 229-231
20. Lehmann K.A., Kratzenberg U., Schroeder-Bark B., and Horrichs-Haermeier G. Post-operative patient-controlled analgesia with tramadol: analgesic efficacy and minimum effective concentration. Clinical Journal of Pain 6 (1990) 212-220
21. Lemke K.A., Runyon C.L., and Horney B.S. Effects of pre-operative administration of ketoprofen on anesthetic requirements and signs of post-operative pain in dogs undergoing elective ovariohysterectomy. Journal of the American Veterinary Medical Association 221 (2002) 1268-1275
22. Mastrocinque S., and Fantoni D.T. A comparison of pre-operative and morphine for the control of early post-operative pain in canine ovariohysterectomy. Veterinary Anaesthesia and Analgesia 30 (2003) 220-228
23. Murthy B.V.S., Pandya K.S., Booker P.D., Murray A., Lintz W., and Terlinden R. Pharmacokinetics of tramadol in children after i.v. or caudal administration in children. British Journal of Anaesthesia 84 (2000) 346-349
24. Natalini C.C., and Robinson E.P. Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol and U50488H in horses. American Journal of Veterinary Research 61 (2000) 1579-1586
25. Nieuwenhuijs D., Bruce J., Drummond G.B., Warren P.M., and Dahan A. Influence of oral tramadol on the dynamic ventilatory response to carbon dioxide in healthy volunteers. British Journal of Anaesthesia 87 (2001) 860-865
26. Osterloh G., Friderichs E., Felgenhauer F., Günzler W.A., Henmi Z., Kitano T., Nakamura M., Hayashi H., and Ishii I. General pharmacological studies on tramadol a potent analgesic agent. Arzneimittelforschung 28 1a (1978) 135-151
27. Ozcengiz D., Gunduz M., Ozbek H., and Isik G. Comparison of caudal morphine and tramadol for post-operative pain control in children undergoing inguinal herniorrhaphy. Pediatric Anaesthesia 11 (2001) 459-464
28. Poulsen L., Arendt-Nielsen L., Brosen K., and Sindrup S.H. The hypoalgesic effect of tramadol in relation to CYP2D6. International Journal of Clinical Pharmacology Therapy and Toxicology 60 (1996) 636-644
29. Prakash S., Tyagi R., Gogia A.R., Singh A.R., and Prakash S. Efficacy of three doses of tramadol with bupivacaine caudal analgesia in paediatric inguinal herniotomy. British Journal of Anaesthesia 97 (2006) 385-388
30. Prosser D.P., Davis A., Booker P.D., and Murray A. Caudal tramadol for post-operative analgesia in paediatric hypospadias surgery. British Journal of Anaesthesia 79 (1997) 293-296
31. Pypendop B.H., and Ilkiw J.E. Pharmacokinetics of tramadol, and its metabolite O-desmethyl tramadol, in cats. Journal of Veterinary Pharmacology and Therapeutics 31 (2008) 52-59
32. Raffa R.B., Friederichs E., Reimann W., Shank R.P., Codd E.E., and Vaught J.L. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an "atypical" opioid analgesic. Journal of Pharmacology and Experimental Therapeutics 260 (1992) 275-285
33. Reese C.J., Trotter E.J., Short C.E., Erb H.N., and Barlow L.L. Assessing the efficacy of perioperative carprofen administration in dogs undergoing surgical repair of a ruptured cranial cruciate ligament. Journal of the American Animal Hospital Association 36 (2000) 448-455
34. Reid J., Nolan A.M., Hughes J.M.L., Lascelles D., Pawson P., and Scott E.M. Development of the short-form Glasgow composite measure pain scale (CMPS-SF) and derivation of an analgesic intervention score. Animal Welfare 16 (2007) 97-104
35. Schenck E.G., and Arend I. The effect of tramadol in an open clinical trial. Arzneimittelforschung 28 (1978) 209-212
36. Scott L.J., and Perry M.P. Tramadol: a review of its use in perioperative pain. Drugs 60 (2000) 139-176
37. Shah S.S., Sanda S., Regmi N.L., Sasaki K., and Shimoda M. Characterization of cytochrome P450-mediated drug metabolism in cats. Journal of Veterinary Pharmacology and Therapeutics 30 (2007) 422-428
38. Shilo Y., Britzi M., Eytan B., Lifschitz T., Soback S., and Steinman A. Pharmacokinetics of tramadol in horses after intravenous, intramuscular and oral administration. Journal of Veterinary Pharmacology and Therapeutics 31 (2008) 60-65
39. Siddik-Sayyid S., Aouad-Maroun M., Sleiman D., Sfeir M., and Baraka A. Epidural tramadol for post-operative pain after cesarean section. Canadian Journal of Anaesthesia 46 (1999) 731-735
40. Skarda R. Local and regional anesthetic and analgesic techniques: dogs. In: Thurmon J.C., Tranquilli W.J., and Benson G.J. (Eds). Lumb and Jones' Veterinary Anesthesia. third ed. (1996), Williams & Wilkins, Baltimore, USA 434-447
41. Slocum B., and Slocum T.D. Tibial plateau levelling osteotomy for repair of cranial cruciate ligament rupture in the canine. Veterinary Clinics of North America: Small Animal Practice 23 (1993) 777-795
42. Thurmon J.C., Tranquilli W.J., and Benson G.J. Perioperative pain and its management. In: Thurmon J.C., Tranquilli W.J., and Benson G.J. (Eds). Essential of Small Animal Anaesthesia and Analgesia. first ed. (1999), Williams and Wilkins, Philadelphia, PA, USA 28-60
43. Vettorato E., Cagnardi P., Isola M., Zonca A., Villa R., and Montesissa C. Bioavailability of tramadol after epidural administration to dogs. Journal of Veterinary Pharmacology and Therapeutics 29 Suppl. 1 (2006) 291-292
44. Vickers M.D., O'Flaherty D., Szekely S.M., Read M., and Yoshizumi J. Tramadol: pain relief by an opioid without depression of respiration. Anaesthesia 47 (1992) 291-296
45. Villa R., Prandini E., Montesissa C., and Carli S. Serum protein binding of β-lactamine derivatives in farm and domestic animals. Proceedings of the 6th International Congress of European Association of Veterinary Pharmacology and Therapeutics, Edinburgh, UK. Journal of Veterinary Pharmacology and Therapeutics (1994) 216-217
46. Villa R., Prandini E., Caloni F., and Carli S. Serum protein binding of some sulphonamides, quinolones and floroquinolones in farm and domestic animals. Journal of Veterinary Pharmacology and Therapeutics 20 Suppl. 1 (1997) 34-35
47. Yaddanapudi L.N., Wig J., Singh B., and Tewari M.K. Comparison of efficacy and side effects of epidural tramadol and morphine in patients undergoing laminectomy: a repeated dose study. Neurology India 48 (2000) 398-400
48. Yamaoka K., Nakagawa T., and Uno T. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics 6 (1978) 165-175
49. Zonca A., Cagnardi P., Carli S., Scrollavezza P., and Villa R. Pharmacokinetics of tramadol in horses. Journal of Veterinary Pharmacology and Therapeutics 29 Suppl. 1 (2006) 290-291