Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs

Journal of Veterinary Pharmacology and Therapeutics

Volumn 27, Issue 4, 2004, Pages 239-246

  Kukanich, B ^a   Papich, M G ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; O NORTRAMADOL; TRAMADOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG SAFETY; FEMALE; HALF LIFE TIME; MALE; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANALGESICS, OPIOID; ANIMALS; AREA UNDER CURVE; CROSS-OVER STUDIES; DOGS; FEMALE; INJECTIONS, INTRAVENOUS; MALE; TRAMADOL;

ANIMALIA; CANIS FAMILIARIS;

EID: 4344658830     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2004.00578.x     Document Type: Article

References (43)

1. Bamigbade, T.A., Davidson, C., Langford, R.M. & Stamford, J.A. (1997) Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus. British Journal of Anaesthia, 79, 352-356.
2. Bloch, M.B., Dyer, R.A., Heijke, S.A. & James, M.F. (2002) Tramadol infusion for postthoracotomy pain relief: a placebo-controlled comparison with epidural morphine. Anesthesia and Analgesia, 94, 523-528.
3. Crossman, M. & Kohnen, C. (1995) General tolerability and adverse event profile of tramadol hydrochloride. Reviews Contemporary Pharmacotherapy, 6, 513-531.
4. Davies, B. & Morris, T. (1993) Physiological parameters in laboratory animals and humans. Pharmaceutical Research, 10, 1093-1095.
5. Driessen, B. & Reimann, W. (1992) Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro. British Journal of Pharmacology, 105, 147-151.
6. Driessen, B., Reimann, W. & Giertz, H. (1993) Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro. British Journal of Pharmacology, 108, 806-811.
7. Gan, S.H. & Ismail, R. (2001) Validation of a high-performance liquid chromatography method for tramadol and o-desmethyltramadol in human plasma using solid-phase extraction. Journal of Chromatography B: Biomedical Sciences and Applications, 759, 325-335.
8. Gan, S.H., Ismail, R., Wan Adnan, W.A. & Wan, Z. (2002) Method development and validation of a high-performance liquid chromatographic method for tramadol in human plasma using liquid-liquid extraction. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 772, 123-129.
9. Garrido, M.J., Valle, M., Campanero, M.A., Calvo, R. & Troconiz, I.F. (2000) Modeling of the in vivo antinociceptive interaction between an opioid agonist, (+)-O-desmethyltramadol, and a monoamine reuptake inhibitor, (-)-O-desmethyltramadol, in rats. Journal of Pharmacology and Experimental Therapeutics, 295, 352-359.
10. Garrido, M.J., Sayar, O., Segura, C., Rapado, J., Dios-Vieitez, M.C., Renedo, M.J. & Troconiz, I.F. (2003) Pharmacokinetic/pharmacodynamic modeling of the antinociceptive effects of (+)-tramadol in the rat: role of cytochrome P450 2D activity. Journal of Pharmacology and Experimental Therapeutics, 305, 710-718.
11. Gibaldi, M. & Perrier, D. (1982) Pharmacokinetics, 2nd edn. pp. 1-494, Marcel Dekker Inc., New York.
12. Grond, S., Meuser, T., Zech, D., Hennig, U. & Lehmann, K.A. (1995) Analgesic efficacy and safety of tramadol enantiomers in comparison with the racemate: a randomised, double-blind study with gynaecological patients using intravenous patient-controlled analgesia. Pain, 62, 313-320.
13. Grond, S., Meuser, T., Uragg, H., Stahlberg, H.J. & Lehmann, K.A. (1999) Serum concentrations of tramadol enantiomers during patient-controlled analgesia. British Journal of Clinical Pharmacology, 48, 254-257.
14. Halfpenny, D.M., Callado, L.F., Hopwood, S.E., Bamigbade, T.A., Langford, R.M. & Stamford, J.A. (1999) Effects of tramadol stereoisomers on norepinephrine efflux and uptake in the rat locus coeruleus measured by real time voltammetry. British Journal of Anaesthesia, 83, 909-915.
15. Hennies, H.H., Friderichs, E. & Schneider, J. (1988) Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids. Arzneimittelforschung, 38, 877-880.
16. Jacqz, E., Ward, S., Johnson, R., Schenker, S., Gerkens, J. & Branch, R.A. (1986) Extrahepatic glucuronidation of morphine in the dog. Drug Metabolism and Disposition, 14, 627-630.
17. Kampa, N., Bostrom, I., Lord, P., Wennstrom, U., Ohagen, P. & Maripuu, E. (2003) Day-to-day variability in glomerular filtration rate in normal dogs by scintigraphic technique. Journal of Veterinary Medicine A, 50, 37-41.
18. Kayser, V., Besson, J.M. & Guilbaud, G. (1992) Evidence for a noradrenergic component in the antinociceptive effect of the analgesic agent tramadol in an animal model of clinical pain, the arthritic rat. European Journal of Pharmacology, 224, 83-88.
19. KuKanich, B. & Papich, M.G. (2004) Pharmacokinetics of morphine and its active metabolite morphine-6-glucuronide following intravenous and oral administration of morphine to dogs. Proceedings of the American College of Veterinary Internal Medicine Forum. Minneapolis, MN, USA. p130.
20. Kyles, A.E., Papich, M. & Hardie, E.M. (1996) Disposition of transdermally administered fentanyl in dogs. American Journal of Veterinary Research, 57, 715-719.
21. Lee, C.R., McTavish, D. & Sorkin, E.M. (1993) Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states. Drugs, 46, 313-340.
22. Lehmann, K.A., Kratzenberg, U., Schroeder-Bark, B. & Horrichs-Haermeyer, G. (1990) Postoperative patient-controlled analgesia with tramadol: analgesic efficacy and minimum effective concentrations. Clinical Journal of Pain, 6, 212-220.
23. Lintz, W. & Uragg, H. (1985) Quantitative determination of tramadol in human serum by gas chromatography-mass spectrometry. Journal of Chromatography, 341, 65-79.
24. Loughrey, M.B., Loughrey, C.M., Johnston, S. & O'Rourke, D. (2003) Fatal hepatic failure following accidental tramadol overdose. Forensic Science International, 134, 232-233.
25. Musshoff, F. & Madea, B. (2001) Fatality due to ingestion of tramadol alone. Forensic Science International, 116, 197-199.
26. Nobilis, M., Kopecky, J., Kvetina, J., Chladek, J., Svoboda, Z., Vorisek, V., Perlik, F., Pour, M. & Kunes, J. (2002) High-performance liquid chromatographic determination of tramadol and its O-desmethylated metabolite in blood plasma. Application to a bioequivalence study in humans. Journal of Chromatography A, 949, 11-22.
27. Nosal'ova, G., Strapkova, A. & Korpas, J. (1991) Relationship between the antitussic and analgesic activity of substances. Acta Physiologica Hungary, 77, 173-178.
28. Oliva, P., Aurilio, C., Massimo, F., Grella, A., Maione, S., Grella, E., Scafuro, M., Rossi, F. & Berrino, L. (2002) The antinociceptive effect of tramadol in the formalin test is mediated by the serotonergic component. European Journal of Pharmacology, 445, 179-185.
29. Pandita, R.K., Pehrson, R., Christoph, T., Friderichs, E. & Andersson, K.E. (2003) Actions of tramadol on micturition in awake, freely moving rats. British Journal of Pharmacology, 139, 741-748.
30. Pinardi, G., Pelissier, T. & Miranda, H.F. (1998) Interactions in the antinociceptive effect of tramadol in mice; an isobolographic analysis. European Journal Pain, 2, 343-350.
31. Poulsen, L., Arendt-Neilsen, L., Brosen, K. & Sindrup, S.H. (1996) The hypoalgesic effect of tramadol in relation to CYP2D6. Clinical Pharmacology and Therapeutics, 60, 636-644.
32. Raffa, R.B., Friderichs, E., Reimann, W., Shank, R.P., Codd, E.E. & Vaught, J.L. (1992) Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. Journal of Pharmacology and Experimental Therapeutics, 260, 275-285.
33. Raffa, R.B., Friderichs, E., Reimann, W., Shank, R.P., Codd, E.E., Vaught, J.L., Jacoby, H.I. & Selve, N. (1993) Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. Journal of Pharmacology and Experimental Therapeutics, 267, 331-340.
34. Riviere, J.E. & Papich, M.G. (2001) Potential and problems of developing transdermal patches for veterinary applications. Advanced Drug Delivery Reviews, 50, 175-203.
35. Scott, L.J. & Perry, C.M. (2000) Tramadol: a review of its use in perioperative pain. Drugs, 60, 139-176.
36. Sevcik, J., Nieber, K., Driessen, B. & Illes, P. (1993) Effects of the central analgesic tramadol and its main metabolite, O-desmethyltramadol, on rat locus coeruleus neurones. British Journal of Pharmacology, 110, 169-176.
37. Shah, V.P., Midha, K.K. & Dighe, S. (1992) Conference report: Analytical methods validation: bioavailability, bioequivalence, and pharmacokinetic studies. International Journal of Pharmaceutics, 82, 1-7.
38. Tao, Q., Stone, D.J., Borenstein, M.R., Codd, E.E., Coogan, T.P., Desai-Krieger, D., Liao, S. & Raffa, R.B. (2002) Differential tramadol and O-desmethyl metabolite levels in brain vs. plasma of mice and rats administered tramadol hydrochloride orally. Journal of Clinical Pharmacology and Therapeutics, 27, 99-106.
39. Tuncer, S., Pirbudak, L., Balat, O. & Capar, M. (2003) Adding ketoprofen to intravenous patient-controlled analgesia with tramadol after major gynecological cancer surgery: a double-blinded, randomized, placebo-controlled clinical trial. European Journal of Gynaecology and Oncology, 24, 181-184.
40. Valle, M., Garrido, M.J., Pavon, J.M., Calvo, R. & Troconiz, I.F. (2000) Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effects of main active metabolites of tramadol, (+)-O-desmethyltramadol and (-)-O-desmethyltramadol, in rats. Journal of Pharmacology and Experimental Therapeutics, 293, 646-653.
41. Webb, A.R., Leong, S., Myles, P.S. & Burn, S.J. (2002) The addition of a tramadol infusion to morphine patient-controlled analgesia after abdominal surgery: a double-blinded, placebo-controlled randomized trial. Anesthesia and Analgesia, 95, 1713-1718.
42. Wilder-Smith, C.H. & Bettiga, A. (1997) The analgesic tramadol has minimal effect on gastrointestinal motor function. British Journal of Clinical Pharmacology, 43, 71-75.
43. Wu, W.N., McKown, L.A., Gauthier, A.D., Jones, W.J. & Raffa, R.B. (2001) Metabolism of the analgesic drug, tramadol hydrochloride, in rat and dog. Xenobiotica, 31, 423-441.