Quantitative MRI predicts status epilepticus-induced hippocampal injury in the lithium-pilocarpine rat model

Epilepsy Research

Volumn 88, Issue 2-3, 2010, Pages 221-230

  Choy, ManKin ^a,b   Cheung, King K ^b,c   Thomas, David L ^c   Gadian, David G ^a   Lythgoe, Mark F ^a,b   Scott, Rod C ^a,d,e  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^e YOUNG EPILEPSY   (United Kingdom)

Author keywords

Brain injury; Epilepsy; MRI; Pilocarpine; Prognostic marker; Status epilepticus

Indexed keywords

LITHIUM; PILOCARPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN SIZE; CELL DEATH; CONTROLLED STUDY; EPILEPTIC STATE; HIPPOCAMPUS; IMAGE DISPLAY; INFLAMMATION; MALE; NEUROPATHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; RAT;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN MAPPING; CELL COUNT; CELL DEATH; CEREBROVASCULAR CIRCULATION; HIPPOCAMPUS; IMAGE PROCESSING, COMPUTER-ASSISTED; LITHIUM; MAGNETIC RESONANCE IMAGING; MALE; ORGAN SIZE; PARIETAL LOBE; PILOCARPINE; PREDICTIVE VALUE OF TESTS; RATS; RATS, SPRAGUE-DAWLEY; STATUS EPILEPTICUS; THALAMUS; TIME FACTORS;

EID: 75849116064     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2009.11.013     Document Type: Article

References (39)

1. Alsop D.C., and Detre J.A. Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. J. Cereb. Blood Flow Metab. 16 (1996) 1236-1249
2. Bhagat Y.A., Obenaus A., Hamilton M.G., and Kendall E.J. Magnetic resonance imaging predicts neuropathology from soman-mediated seizures in the rodent. Neuroreport 12 (2001) 1481-1487
3. Cavanagh J.B., and Meyer A. Aetiological aspects of Ammon's horn sclerosis associated with temporal lobe epilepsy. Br. Med. J. 44 (1956) 1403-1407
4. De Simoni M.G., Perego C., Ravizza T., Moneta D., Conti M., Marchesi F., De Luigi A., Garattini S., and Vezzani A. Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. Eur. J. Neurosci. 12 (2000) 2623-2633
5. Dube C., Yu H., Nalcioglu O., and Baram T.Z. Serial MRI after experimental febrile seizures: altered T2 signal without neuronal death. Ann. Neurol. 56 (2004) 709-714
6. Ebisu T., Rooney W.D., Graham S.H., Mancuso A., Weiner M.W., and Maudsley A.A. MR spectroscopic imaging and diffusion-weighted MRI for early detection of kainate-induced status epilepticus in the rat. Magn. Reson. Med. 36 (1996) 821-828
7. Engel Jr. J. Introduction to temporal lobe epilepsy. Epilepsy Res. 26 (1996) 141-150
8. Fabene P.F., Marzola P., Sbarbati A., and Bentivoglio M. Magnetic resonance imaging of changes elicited by status epilepticus in the rat brain: diffusion-weighted and T2-weighted images, regional blood volume maps, and direct correlation with tissue and cell damage. Neuroimage 18 (2003) 375-389
9. Fujikawa D.G. The temporal evolution of neuronal damage from pilocarpine-induced status epilepticus. Brain Res. 725 (1996) 11-22
10. Greene N.D., Bamidele A., Choy M., de Castro S.C., Wait R., Leung K.Y., Begum S., Gadian D.G., Scott R.C., and Lythgoe M.F. Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus. Proteomics 7 (2007) 1336-1344
11. Ingvar M. Cerebral blood flow and metabolic rate during seizures. Relationship to epileptic brain damage. Ann. N Y Acad. Sci. 462 (1986) 194-206
12. Jackson G.D., Berkovic S.F., Tress B.M., Kalnins R.M., Fabinyi G.C., and Bladin P.F. Hippocampal sclerosis can be reliably detected by magnetic resonance imaging. Neurology 40 (1990) 1869-1875
13. Kato H., Kogure K., Ohtomo H., Tobita M., Matsui S., Yamamoto E., and Kohno H. Correlations between proton nuclear magnetic resonance imaging and retrospective histochemical images in experimental cerebral infarction. J. Cereb. Blood Flow Metab. 5 (1985) 267-274
14. Kharatishvili I., Immonen R., Grohn O., and Pitkanen A. Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis. Brain 130 (2007) 3155-3168
15. Klitgaard H., Matagne A., Vanneste-Goemaere J., and Margineanu D.G. Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations. Epilepsy Res. 51 (2002) 93-107
16. Koerner I.P., and Brambrink A.M. Brain protection by anesthetic agents. Curr. Opin. Anaesthesiol. 19 (2006) 481-486
17. Lukasiuk K., and Pitkanen A. Gene and protein expression in experimental status epilepticus. Epilepsia 48 Suppl. 8 (2007) 28-32
18. Lythgoe M.F., Thomas D.L., King M.D., Pell G.S., van der W.L., Ordidge R.J., and Gadian D.G. Gradual changes in the apparent diffusion coefficient of water in selectively vulnerable brain regions following brief ischemia in the gerbil. Magn. Reson. Med. 53 (2005) 593-600
19. Mathern G.W., Adelson P.D., Cahan L.D., and Leite J.P. Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited. Prog. Brain Res. 135 (2002) 237-251
20. Meldrum B.S., and Nilsson B. Cerebral blood flow and metabolic rate early and late in prolonged epileptic seizures induced in rats by bicuculline. Brain 99 (1976) 523-542
21. Mihaly A., Shihab-Eldeen A., Owunwanne A., Gopinath S., Ayesha A., and Mathew M. Acute 4-aminopyridine seizures increase the regional cerebral blood flow in the thalamus and neocortex, but not in the entire allocortex of the mouse brain. Acta Physiol. Hung. 87 (2000) 43-52
22. Nairismagi J., Grohn O.H., Kettunen M.I., Nissinen J., Kauppinen R.A., and Pitkanen A. Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepsy. Epilepsia 45 (2004) 1024-1034
23. Nakasu Y., Nakasu S., Morikawa S., Uemura S., Inubushi T., and Handa J. Diffusion-weighted MR in experimental sustained seizures elicited with kainic acid. AJNR Am. J. Neuroradiol. 16 (1995) 1185-1192
24. Okamoto H., Ito O., Roman R.J., and Hudetz A.G. Role of inducible nitric oxide synthase and cyclooxygenase-2 in endotoxin-induced cerebral hyperemia. Stroke 29 (1998) 1209-1218
25. Parent J.M., Yu T.W., Leibowitz R.T., Geschwind D.H., Sloviter R.S., and Lowenstein D.H. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J. Neurosci. 17 (1997) 3727-3738
26. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1998), Academic Press, San Diego
27. Provenzale J.M., Barboriak D.P., VanLandingham K., MacFall J., Delong D., and Lewis D.V. Hippocampal MRI signal hyperintensity after febrile status epilepticus is predictive of subsequent mesial temporal sclerosis. AJR Am. J. Roentgenol. 190 (2008) 976-983
28. Raspall-Chaure M., Chin R.F., Neville B.G., and Scott R.C. Outcome of paediatric convulsive status epilepticus: a systematic review. Lancet Neurol. 5 (2006) 769-779
29. Righini A., Pierpaoli C., Alger J.R., and Di Chiro G. Brain parenchyma apparent diffusion coefficient alterations associated with experimental complex partial status epilepticus. Magn. Reson. Imaging 12 (1994) 865-871
30. Roch C., Leroy C., Nehlig A., and Namer I.J. Magnetic resonance imaging in the study of the lithium-pilocarpine model of temporal lobe epilepsy in adult rats. Epilepsia 43 (2002) 325-335
31. Scott R.C., Gadian D.G., King M.D., Chong W.K., Cox T.C., Neville B.G., and Connelly A. Magnetic resonance imaging findings within 5 days of status epilepticus in childhood. Brain 125 (2002) 1951-1959
32. Scott R.C., King M.D., Gadian D.G., Neville B.G., and Connelly A. Prolonged febrile seizures are associated with hippocampal vasogenic edema and developmental changes. Epilepsia 47 (2006) 1493-1498
33. Sloviter R.S. The neurobiology of temporal lobe epilepsy: too much information, not enough knowledge. C R Biol. 328 (2005) 143-153
34. Statler K.D., Alexander H., Vagni V., Holubkov R., Dixon C.E., Clark R.S., Jenkins L., and Kochanek P.M. Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury. Brain Res. 1076 (2006) 216-224
35. Thomas D.L., Lythgoe M.F., Gadian D.G., and Ordidge R.J. Rapid simultaneous mapping of T2 and T2* by multiple acquisition of spin and gradient echoes using interleaved echo planar imaging (MASAGE-IEPI). Neuroimage 15 (2002) 992-1002
36. Turrin N.P., and Rivest S. Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. Neurobiol. Dis. 16 (2004) 321-334
37. VanLandingham K.E., Heinz E.R., Cavazos J.E., and Lewis D.V. Magnetic resonance imaging evidence of hippocampal injury after prolonged focal febrile convulsions. Ann. Neurol. 43 (1998) 413-426
38. Wasterlain C.G., Fujikawa D.G., Penix L., and Sankar R. Pathophysiological mechanisms of brain damage from status epilepticus. Epilepsia 34 Suppl. 1 (1993) S37-S53
39. White H.S. Animal models of epileptogenesis. Neurology 59 (2002) S7-S14