Gradual changes in the apparent diffusion coefficient of water in selectively vulnerable brain regions following brief ischemia in the gerbil

Magnetic Resonance in Medicine

Volumn 53, Issue 3, 2005, Pages 593-600

  Lythgoe, Mark F ^a   Thomas, David L ^a,b   King, Martin D ^a   Pell, Gaby S ^a,b,c,d   Van Der Weerd, Louise ^a   Ordidge, Roger J ^b   Gadian, David G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Brain Research Institute   (Austria)

^d AUSTIN HEALTH   (Australia)

Author keywords

Apoptosis; Cerebral ischemia; Delayed cell death; Hypoperfusion; Magnetic resonance imaging; Secondary energy failure

Indexed keywords

ANIMALS; BRAIN; CELL DEATH; MAGNETIC RESONANCE IMAGING;

APPARENT DIFFUSION COEFFICIENT; ARTERIAL SPIN LABELING; CEREBRAL ISCHEMIA; ENERGY FAILURE; FLOW SENSITIVE ALTERNATING INVERSION RECOVERIES; HYPOPERFUSION; PERFUSION-WEIGHTED IMAGING; TIME-DEPENDENT CHANGES;

SURFACE DIFFUSION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL GANGLION; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN REGION; CAROTID ARTERY OBSTRUCTION; CELL DAMAGE; COMMON CAROTID ARTERY; CONTROLLED STUDY; CORPUS STRIATUM; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; FLOW SENSITIVE ALTERNATING INVERSION RECOVERY; GERBIL; NERVE CELL NECROSIS; NON INVASIVE MEASUREMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERFUSION WEIGHTED IMAGING; RADIOLOGICAL PARAMETERS; REPERFUSION; SPIN LABELING; TIME; WATER TRANSPORT;

EID: 14744288475     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.20372     Document Type: Article

References (40)

1. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 1982;239:57-69.
2. Pulsinelli WA, Brierley JB, Plum F. Temporary profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 1982;11:491-498.
3. Li F, Liu K-A, Silva MD, Omae T, Sotak C, Fenstermacher JD, Fisher M. Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia. Stroke 2000;31:946-954.
4. Petito CK, Feldmann E, Pulsinelli WA, Plum F. Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology 1987;37:1281-1286.
5. Hope PL, Reynolds EOR. Investigation of cerebral energy metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy. Clin Perinatol 1985;12:261-275.
6. Fujioka M, Toshiaki T, Hiramatsu K-I, Sakaguchi S, Sakaki T. Delayed ischemic hyperintensity on T1-weighted MRI in he caudoputamen and cerebral cortex of humans after spectacular shrinking deficit. Stroke 1999;30:1038-1042.
7. Hossmann KA. Reperfusion of the brain after global ischemia: hemodynamic disturbances. Shock 1997;8:95-101.
8. Siesjo BK. Pathophysiology and treatment of focal cerebral ischemia. Part II: mechanisms of damage and treatment. J Neurosurg 1992;77:337-354.
9. Bodsch W, Takahashi K, Barbier A, Ophoff BG, Hossmann KA. Cerebral protein synthesis and ischemia. Prog Brain Res 1985;63:197-210.
10. Barone FC, Feuerstein GZ. Inflammatory mediators and stroke: new opportunities for novel therapies. J Cereb Blood Flow Metab 1999;19:819-834.
11. Siesjo BK, Agardh C-D, Bengtsson F. Free radicals and brain damage. Cerebrovasc Brain Metab Rev 1989;1:165-211.
12. Abe K, Aoki M, Kawagoe J, Yoshida T, Hattori A, Kogure K, Itoyama Y. Ischemia delayed neuronal death. A mitochondrial hypothesis. Stroke 1995;26:1478-1489.
13. Du C, Hu R, Csernansky CA, Hsu CY, Choi DW. Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis. J Cereb Blood Flow Metab 1996;16:195-201.
14. Nasagawa H, Kogure K. Correlation between cerebral blood flow and histological changes in a rat model of middle cerebral artery occlusion. Stroke 1989;20:1037-1043.
15. MacManus JP, Linnik MD. Gene expression induced by cerebral ischemia: an apoptotic perspective. J Cereb Blood Flow Metab 1997;17:815-832.
16. Lipton P. Ischemic cell death in neurons. Physiol Rev 1999;79:1431-1568.
17. Zhong I, Petroff OAC, Pritchard JW, Gore JC. Changes in water diffusion and relaxation properties of rat cerebellum during status epilepticus. Magn Reson Med 1993;30:241-246.
18. Thomas DL, Lythgoe MF, Pell GS, Calamante F, Ordidge RJ. The measurement of diffusion and perfusion in biological systems using magnetic resonance imaging. Phys Med Biol 2000;45:R97-R138.
19. Moseley ME, Cohen Y, Mintorovitch J, Chileuitt L, Shimizu H, Kucharczyk J, Wendland MF, Weinstein PR. Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy. Magn Reson Med 1990;14:330-346.
20. Pell GS, Lythgoe MF, Thomas DL, Calamante F, King MD, Gadian DG, Ordidge RJ. Reperfusion in a gerbil model of forebrain ischemia using serial magnetic resonance FAIR perfusion imaging. Stroke 1999;30:1263-1270.
21. Pell GS, Thomas DL, Lythgoe MF, Calamante F, Howseman AM, Gadian DG, Ordidge RJ. The implementation of quantitative FAIR perfusion imaging with a short repetition time in time-course studies. Magn Reson Med 1999;41:829-840.
22. Wong EC, Cox RW, Song AW. Optimized isotropic diffusion weighting. Magn Reson Med 1995;34:139-143.
23. Wolfinger RD. Comment: experiences with the SAS Macro NLINMIX. Stat Med 1997;16:1258-1259.
24. Does MD, Zhong J, Gore JC. In vivo measurement of ADC change due to intravascular susceptibility variation. Magn Reson Med 1999;41:236-240.
25. Crain BJ, Westerkam WD, Harrison AH, Nadler JV. Selective neuronal death after transient forebrain ischemia in the Mongolian gerbil: a silver impregnation study. Neuroscience 1988;27:387-402.
26. Busza AL, Allen KL, King MD, Van Bruggen N, Williams SR, Gadian DG. Diffusion-weighted imaging studies of cerebral ischemia in gerbils. Potential relevance to energy failure. Stroke 1992;23:1602-1612.
27. Thornton JS, Ordidge RJ, Penrice J, Cady EB, Amess PN, Punwani S, Clemence M, Wyatt JS. Temporal and anatomical variations of brain water apparent diffusion coefficient in perinatal cerebral hypoxic-ischemic injury: relationships to cerebral energy metabolism. Magn Reson Med 1998;39:920-927.
28. Dijkhuizen RM, Knollema S, van der Worp HB, ter Horst GJ, de Wildt DJ, Berkelbach van der Spenkel JW, Tullenken CAF, Nicolay K. Dynamics of cerebral tissue injury and perfusion after temporary hypoxia-ischemia in the rat: evidence for region-specific sensitivity and delayed damage. Stroke 1998;29:695-704.
29. van Lookeren Campagne M, Thomas GR, Thibodeaux H, Palmer JT, Williams SP, Lowe DG, Van Bruggen N. Secondary reduction in the apparent diffusion coefficient, increase in cerebral blood volume and delayed neuronal death following middle cerebral artery occlusion and early reperfusion in the rat. J Cereb Blood Flow Metab 1999;19:1354-1364.
30. Olah L, Wecker S, Hoehn M. Secondary deterioration of apparent diffusion coefficient after 1-hour transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2000;20:1474-1482.
31. Olah L, Wecker S, Hoehn M. Relation of apparent diffusion coefficient changes and metabolic disturbances after 1 hour of focal cerebral ischemia and at different reperfusion phases in rats. J Cereb Blood Flow Metab 2001;21:430-439.
32. Neumann-Haefelin T, Kastrup A, de Crespigny AJ, Yenari MA, Ringer T, Sun GH, Moseley ME. Serial MRI after transient focal cerebral ischemia in rats. Stroke 2000;31:1965-1973.
33. Latour LL, Svoboda K, Mitra PP, Sotak CH. Time-dependent diffusion of water in a biological model system. Proc Natl Acad Sci USA 1994;91:1229-1233.
34. Hasegawa Y, Formato JE, Latour LL, Gutierrez JA, Liu KF, Garcia JH, Sotak CH, Fisher M. Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water. Stroke 1996;27:1648-1656.
35. Helpern JA, Ordidge RJ, Knight RA. The effect of cell membrane water permeability on the diffusion coefficient of water. In: Proceedings of the 11th Annual Meeting of SMRM, Berlin, Germany, 1992.
36. van der Toorn A, Verheul HB, Berkelbach van der Spenkel JW, Tullenken CAF, Nicolay K. Changes in metabolites and tissue water status after focal ischemia in cat brain assessed with localized proton MR spectroscopy. Magn Reson Med 1994;32:685-691.
37. 19F NMR. Magn Reson Med 1998;40:1-13.
38. Hochachka PW. The metabolic implications of intracelluar circulation. Proc Natl Acad Sci USA 1999;96:12233-12239.
39. Stummer W, Baethmann A, Murr R, Schurer L, Kempski OS. Cerebral protection against ischemia by locomotor activity in gerbils. Underlying mechanisms. Stroke 1995;26:1423-1430.
40. Safar P, Xiao F, Radovsky A, Tanigawa K, Ebmyer U, Bircher N, Alexander H, Stezoski SW. Improved cerebral resuscitation from cardiac arrest in dogs with mild hypothermia plus blood flow promotion. Stroke 1996;27:105-113.