Ion transport in a human lens epithelial cell line exposed to hyposmotic and apoptotic stress

Journal of Cellular Physiology

Volumn 223, Issue 1, 2010, Pages 110-122

  Chimote, Ameet A ^a   Adragna, Norma C ^a   Lauf, Peter K ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANNEXIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; CLOTRIMAZOLE; POTASSIUM; RUBIDIUM; STAUROSPORINE;

APOPTOSIS; ARTICLE; CELL STRESS; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; ION CONDUCTANCE; ION TRANSPORT; LENS; MEMBRANE BINDING; MUSCLE HYPOTONIA; OSMOTIC STRESS; POTASSIUM CELL LEVEL; POTASSIUM DEPLETION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; WATER CONTENT;

4-AMINOPYRIDINE; ANNEXIN A5; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL SIZE; EPITHELIAL CELLS; HUMANS; HYPOTONIC SOLUTIONS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; ION TRANSPORT; LENS, CRYSTALLINE; OSMOTIC PRESSURE; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; PROTEIN KINASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RUBIDIUM; SIGNAL TRANSDUCTION; STAUROSPORINE; STRESS, PHYSIOLOGICAL; TIME FACTORS; WATER;

EID: 75749150533     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22015     Document Type: Article

References (61)

1. Adragna NC. 1988. Changes in cation composition of aortic endothelial cells in culture. Tissue Cell 20:313-329.
2. Adragna N. 1991. Cation transport in vaxcular endothelial cells and aging. J Membr Biol 124:285-291.
3. Aiton J, Lamb J, Ogden P. 1981. Down-regulation of the sodium pump following chronic exposure of HeLa cells and chick embryo heart cells to ouabain. Br J Pharmicol 73:333-340.
4. Andley U, Rhim J, Chylack Jr. L, Fleming T. 1994. Propogation and immortalization of human lens epithelial cells in culture. Invest Ophthalmol Vis Sci 35:3094-3102.
5. + channel (BKCa) currents in rabbit pulmonary arterial smooth muscle cells. Korean J Physiol Pharmacol 7:25-28.
6. Beebe D, Pharmelee J, Belcher K. 1990. Volume regulation in lens epithelial cells and differentiating lens fiber cells. J Cell Physiol 1990:3.
7. Bortner C, Cidlowski J. 1996. Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes. J Cell Physiol 143:455-459.
8. Bortner C, Cidlowski J. 1998. A necessary role for cell shrinkage in apoptosis. Biochem Pharmacol 56:1549-1559.
9. Bortner C, Cidlowski J. 2000. Volume regulation and ion transport during apoptosis. Methods Enzymol 322:33.
10. Bortner C, Cidlowski J. 2002. Apoptotoic volume decrease and the incredible shrinking cell. Cell Death Differ 9:1307-1310.
11. Bortner C, Cidlowski J. 2003. Uncoupling cell shrinkage from apoptosis reveals that Na+ influx is required for volume loss during programmed cell death. J Biol Chem 278:39176-39184.
12. Bortner C, Cidlowski J. 2004. The role of apoptotic volume decrease and ionic homeostasis in the activation and repression of apoptosis. Pflugers Archiv: Eur J Physiol 448:176-188.
13. Bortner C, Cidlowski J. 2007. Cell shrinkage and monovalent cation fluxes: Role in apoptosis. Arch Biochem Biophys 462:176-188.
14. Brakemeier S, Kersten A, Eichler I, Grgic I, Zakrzewicz A, Hopp H. 2003. Shear stressinduced up-regulation of the intermeidate-conductance Ca(2+)-actovated K(+) channel in human endothelium. Cardiovasc Res 60:488-496.
15. Brenova E, Platoshyn O, Zhang S, Yuan J. 2004. Overexpression of human KCNA5 increases IK V and enhances apoptosis. Am J Physiol Cell Physiol 287:C715-C722.
16. Candia O. 2004. Electrolyte and fluid transport across corneal, conjunctival, and lens epithelia. Exp Eye Res 78:527-535.
17. Cidlowski J, Bortner C, Gomez-Angelats M, Mann C, Scoltock A, Huang J. 2000. The cell and molecular bioloby of apoptosis in T-lymphocyes. Ann Endocrinol 61:138.
18. Elliott J, Higgins C. 2003. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosis. EMBO Rep 4:189-194.
19. Fay A, Quian X, Jan Y, Jan L. 2006. SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes. Proc Nat Acad Sci 103:17548-17553.
20. Gagnon K, Fyffe R, Adragna N, Lauf P. 2007. Characterization of an extracellular epitope antibody to the neuronal K-Cl cotransporter, KCC2. Clin Exp Pharmacol Physiol 34:566-573.
21. Han X, Patters A, Jones D, Zelikovic I, Chesney R. 2003. The taurine transporter: Mechanisms of regulation. Acta Physiologica (Oxford, Eng) 187:61-73.
22. Heimlich G, Bortner C, Cidlowski J, editors. 2004. Apoptosis and cell volume regulation the importance of ions and channels. Advances in experimental medicine and biology. New York: Springer.
23. Hoffmann E, Schettino T, Marshall W. 2007. The role of volume-sensitive ion transport systems in regulation of epithelial transport. Comp Biochem Physiol A Mol Integr Physiol 148:29-43.
24. Hoffmann E, Lambert I, Pedersen S. 2009. Physiology of cell volume regulation in vertebrates. Physiol Rev 89:193-277.
25. Hughes F, Jr., Bortner C, Purdy G, Cidlowski J. 1997. Intracellular K+ suppresses the activation of apoptosis in lymphocytes. J Biol Chem 272:30567-30576.
26. Ito C, Tecchio C, Coustan-Smith E, Suzuki T, Behm F, Raimondi S. 2002. The antifungal antibiotic clotrimazole alters calcium homeostasis of leukemic lymphoblasts and induces apoptosis. Leukemia 16:1344-1352.
27. Jablonski E, Webb A, McConnell N, Riley M, Hughes Jr F. 2004. Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease. Am J Physiol Cell Physiol 286:C975-C985.
28. Khanna R, Chang M, Joiner W, Kaczmarek L, Schlichter L. 1999. hSK4/hIK1, a calmoudulinbinding Kca channel in human T lymphocytes. J Biol Chem 274:14838-14849.
29. Lauf P. 1983. Thiol-dependent passive K/Cl transport in sheep red cells:I. Dependence on chloride and external K+[Rb+] ion. J Membr Biol 73:237-246.
30. Lauf P, Warwar R, Brown T, Adragna N. 2006. Regulation of potassium transport in human lens epithelial cells. Exp Eye Res 82:55-64.
31. Lauf P, Misri S, Chimote A, Adragna N. 2008. Apparent intermidiate K conductance channel hyposmotic activation in human lens epithelial cells. Am J Physiol Cell Physiol 294:C820-C832.
32. Levine A. 2009. The comomn mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53. Virology 384:285-293.
33. Lu L. 2006. Stress-induced corneal epithelial apoptosis mediated by K+ channel activation. Prog Retin Eye Res 25:515-538.
34. Maeno E, Ishizaki Y, Kanaseki T, Hazama A, Okada Y. 2000. Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc Nat Acad Sci 97:9487-9492.
35. Maeno E, Takahashi N, Okada Y. 2006. Dysfunction of regulatory volume increase is a key component of apoptosis. EB Lett 580:6513-6517.
36. Martin S, Reutelingsperger C, McGahon A, Rader J, Van Schie R, LaFace D. 1995. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl. J Exp Med 182:1545-1556.
37. Mathias S, Rae J. 2004. The lens: Local tranport and global tranparency. Exp Eye Res 78:689-698.
38. Mathias S, Kistler J, Donaldson P. 2007. The lens circulation. J Membr Biol 216:1-16.
39. Misri S, Chimote A, Adragna N,Warwar R, Brown T, Lauf P. 2006. KCC isoforms in a human lens epithelial cell line (B3) and lens tissue extracts. Exp Eye Res 83:1287-1294.
40. Mongin A, Orlov S. 2001. Mechanisms of cell volume regulation and possible nature of the cell volume sensor. Pathophysiology 8:77-88.
41. Nobel C, Aronson J, van den Dobbelsteen D, Slater A. 2000. Inhibition of Na+/K(+)-ATPase may be one mechanism contributing to potassium efflux and cell shrinkage in CD95-induced apoptosis. Apoptosis 5:153-163.
42. O'Grady S, Lee S. 2005. Molecular diversity and function of voltage-gated (Kv) potassium channels in epithelial cells. Int J Biochem Cell Biol 37:1578-1594.
43. Okada Y. 2004. Ion channels and tranporters involved in cell volume regulation and sensor mechanisms. Cell Biochem Biophys 41:233-258.
44. Okada Y, Maeno E. 2001. Apoptosis: Cell volume regulation and volume-regulatory chloride channels. Biochem Physiol A Mol Integr Physiol 130:377-383.
45. Okada Y, Maeno E, Shimizu T, Dezaki K, Wang J, Morishima S. 2001. Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD). J Physiol 532:3-16.
46. Orlov S, Thorin-Trescases N, Kotelevstev S, Tremblay J, Hamet P. 1999. Inversion of the intracellular Na+/K+ ratio blocks apoptosis in vascular smooth muscle at a site upstream of caspase-3. J Biol Chem 274:16545-16552.
47. Orlov S, Pchejetski D, Taurin S, Thorin-Trescases N, Maximov G, Pshezhesky A. 2004. Apoptosis in serum-deprived vascular smooth muscle cells: Evidence for cell volumeindependent mechanism. Apoptosis 9:55-66.
48. Rhodes J, Collison D, Duncan G. 2003. Calcium activates SKchannels in the intact human lens. Inv Ophth Chem 44:3927-3932.
49. Ruegg U, Burgess G. 1989. Staurosporine, K-252 and Ucn-01: Potent but nonspecific inhibitors of protein kinases. Trends Pharmacol Sci 10:218-220.
50. Shimizu T, Wehner F, Okada Y. 2006. Inhibition of hypertonicity-induced cation channels sensitizes HeLa cells to shrinkage-induced apoptosis. Cell Physiol Biochem 18:294-302.
51. Shimizu T, Maeno E,Okada Y. 2007. Prerequisite role of persistent cell shrinkage in apoptosis of human epithelial cells. Sheng Li Xue Bao Acta Physiol Sinica 59:512-516.
52. Szabo I, Lepple-Wienhues A, Kaba K, Zoratti M, Gulbins E, Lang F. 1998. Tyrosine kinasedependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes. Proc Nat Acad Sci USA 95:6169-6174.
53. Thompson G, Langlais C, Conley E, Cohen G. 2001. Elevated extracellular [K+] inhibits death-receptor and chemical-mediated apoptosis prior to caspase activation and cytochrome c release. Biochem J 357:137-145.
54. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. 1995. A novel assay for apoptosis. Flow cyometric detection of phosphatidylserine expression on early apoptotic Cells using fluorescein labeled Annexin V. J Immunol Methods 184:39-51.
55. Wang L, Xu D, Dai W, Lu L. 1999. An ultraviolet-activated K+channel mediates apoptosis of myeloblastic leukemia cells. J Biol Chem 274:3678-3685.
56. Wang J, Morishima S, Okada Y. 2003. IK channels are involved in the regulatory volume decrease in human epithelial cells. Am J Physiol Cell Physiol 284:C77-C84.
57. Wehner F. 2006. Cell volume-regulated cation channels. Contrib Nephrol 152:25-53.
58. Weskamp M, Seidl W, Grissmer S. 2000. Characterization of the increase in [Ca(2+)](i) during hypotonic shock and the involvement of Ca(2+)-activated K(+) channels in the regulatory decrease in human osteoblast-like cells. J Membr Biol 178:11-20.
59. Wulff H, Gutman G, Cahalan M, Chandy K. 2001. Delineation of the clotrimazole/TRAM-34 binding site on teh intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem 276:32040-32045.
60. Wyllie A, Kerr J, Currie A. 1980. Cell death: The significance of apoptosis. Int Rev Cytol 68:251-306.
61. Zhao Y, Sun L, Zhou H,Wang X. 2006. Voltage-dependent potassium channels are involved in glutamate-induced apoptosis of rat hippocampal neurons. Neurosci Lett 398:22-27.