Pharmacokinetics of 23-Epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh

Clinical Pharmacology and Therapeutics

Volumn 87, Issue 2, 2010, Pages 219-225

  Van Breemen, R B ^a   Liang, W ^a   Banuvar, S ^a   Shulman, L P ^a   Pang, Y ^a   Tao, Y ^a   Nikolic, D ^a   Krock, K M ^a   Fabricant, D S ^a   Chen, S N ^a   Hedayat, S ^a   Bolton, J L ^a   Pauli, G F ^a   Piersen, C E ^a   Krause, E C ^a   Geller, S E ^a   Farnsworth, N R ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

23 EPI 26 DEOXYACTEIN; ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; ASTRAGALOSIDE IV; BILIRUBIN; CIMICIFUGA RACEMOSA EXTRACT; ESTRADIOL; ESTROGEN; ESTRONE; FOLLITROPIN; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; THYROTROPIN; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD CHEMISTRY; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG SAFETY; DRUG STABILITY; DRUG URINE LEVEL; FEMALE; HORMONE BLOOD LEVEL; HUMAN; LIQUID CHROMATOGRAPHY; LIVER FUNCTION TEST; MAXIMUM ALLOWABLE CONCENTRATION; MAXIMUM TOLERATED DOSE; MENOPAUSE; NONHUMAN; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PLANT ROOT; PRIORITY JOURNAL; RHIZOME; SINGLE DRUG DOSE; STANDARDIZATION; TANDEM MASS SPECTROMETRY; URINALYSIS;

ADMINISTRATION, ORAL; AREA UNDER CURVE; CIMICIFUGA; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HALF-LIFE; HUMANS; MAXIMUM TOLERATED DOSE; MENOPAUSE; MIDDLE AGED; PLANT EXTRACTS; SAPONINS; TRITERPENES;

EID: 75749103266     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2009.251     Document Type: Article

References (29)

1. Lieberman, S. a review of the efectiveness of Cimicifuga racemosa (black cohosh) for the symptoms of menopause. J. Womens Health 7, 525-529 (1998).
2. Compton J.A., Culham A., Jury S.L. Reclassifcation of actaea to include Cimicifuga and Souliea (Ranunculaceae): Phylogeny inferred from morphology, nrDNa ITS, and epDNa trnL-f sequence variation. Taxon 47, 593-634 (1998).
3. Foster S. Black cohosh, Cimicifuga racemosa, a literature review. Herbalgram 45, 35-50 (1999).
4. Liske, E. Therapeutic efcacy and safety of Cimicifuga racemosa for gynecologic disorders. Adv. Ther. 15, 45-53 (1998)
5. Kronenberg F., Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann. Intern. Med. 137, 805-813 (2002).
6. Mahady, G.B., Parrot, J., Lee, C., yun, G.S. & Dan, a. Botanical dietary supplement use in peri-and postmenopausal women. Menopause 10, 65-72 (2003).
7. McKenna, D.J., Jones, K., Humphrey, S. & Hughes, K. Black cohosh: efcacy, safety, and use in clinical and preclinical applications. Altern. Ther. Health Med. 7, 93-100 (2001). (Pubitemid 32423642)
8. Burdette, J.E. et al. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNa damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles. J. Agric. Food Chem. 50, 7022-7028 (2002)
9. Borrelli F., Izzo A.A., Ernst E. Pharmacological efects of Cimicifuga racemosa. Life Sci. 73, 1215-1229 (2003).
10. Hostanska K., Nisslein T., Freudenstein J., Reichling J., Saller R. Cimicifuga racemosa extract inhibits proliferation of estrogen receptor-positive and negative human breast carcinoma cell lines by induction of apoptosis. Breast Cancer Res. Treat. 84, 151-160 (2004).
11. Jeuken A., Keser B.J., Khan E., Brouwer A., Koeman J., Denison M.S. activation of the ah receptor by extracts of dietary herbal supplements, vegetables, and fruits. J. Agric. Food Chem. 51, 5478-5487 (2003).
12. Sakurai, N. et al. anti-aIDS agents. Part 57: actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins. Bioorg. Med. Chem. Lett. 14, 1329-1332 (2004)
13. Kusano A., Seyama Y., Nagai M., Shibano M. Kusano G. Efects of fukinolic acid and cimicifugic acids from Cimicifuga species on collagenolytic activity. Biol. Pharm. Bull. 24, 1198-1201 (2001).
14. Einbond, L.S. et al. Growth inhibitory activity of extracts and purifed components of black cohosh on human breast cancer cells. Breast Cancer Res. Treat. 83, 221-231 (2004).
15. Liu, J. et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J. Agric. Food Chem. 49, 2472-2479 (2001).
16. Einer-Jensen N., Zhao J., Andersen K.P. Kristofersen K., Cimicifuga and Melbrosia lack oestrogenic efects in mice and rats, Maturitas, 1996, 25, 149-153.
17. Mahady, G.B. Is black cohosh estrogenic? Nutr. Rev. 61, 183-186 (2003).
18. Burdette, J.E. et al. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J. Agric. Food Chem. 51, 5661-5670 (2003).
19. Powell, S.L. et al. In vitro serotonergic activity of black cohosh and identifcation of N(omega)-methylserotonin as a potential active constituent. J. Agric. Food Chem. 56, 11718-11726 (2008).
20. Qiu, S.X. et al. a triterpene glycoside from black cohosh that inhibits osteoclastogenesis by modulating RaNKL and TNfalpha signaling pathways. Chem. Biol. 14, 860-869 (2007).
21. Chen, S.N. et al. Isolation, structure elucidation, and absolute confguration of 26-deoxyactein from Cimicifuga racemosa and clarifcation of nomenclature associated with 27-deoxyactein. J. Nat. Prod. 65, 601-605 (2002).
22. He, K., Zheng, B., Kim, C.H., Rogers, L. & Zheng, Q. Direct analysis and identifcation of triterpene glycosides by LC/MS in black cohosh, Cimicifuga racemosa, and in several commercially available black cohosh products. Planta Med. 66, 635-640 (2000).
23. Li, W. et al. High-performance liquid chromatographic analysis of black cohosh (Cimicifuga racemosa) constituents with in-line evaporative light scattering and photodiode array detection. Anal. Chim. Acta. 471, 61-75 (2002).
24. Mahady, G.B. et al. United States Pharmacopeia review of the black cohosh case reports of hepatotoxicity. Menopause 15, 628-638 (2008).
25. fabricant, D.S. Pharmacognostic Investigation of Black Cohosh (Cimicifuga racemosa (L.) Nutt.). PhD dissertation, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago (2006).
26. Breemen, R.B., fong, H.H.S., Farnsworth N.R. Ensuring the safety of botanical dietary supplements. Am. J. Clin. Nutr. 87 (suppl. 1), 509S-513S (2008)
27. Farnsworth N.R., Krause E.C., Bolton J.L., Pauli G.f.,Van Breemen R.B., Graham J.G. The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use. Am. J. Clin. Nutr. 87, 504S-508S (2008).
28. US Pharmacopeial Convention. Dissolution. US Pharmacopeia 28. (2005).
29. US Pharmacopeial Convention. Simulated gastric fuid. US Pharmacopeia 23. (Rockville, MD: In the National formulary 18, 1995); p.2053