Pharmacological effects of Cimicifuga racemosa

Life Sciences

Volumn 73, Issue 10, 2003, Pages 1215-1229

  Borrelli, F ^a   Izzo, A A ^a   Ernst, E ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

Black cohosh; Cimicifuga racemosa; Climacteric disorders; Herbal medicine; Mechanism of action; Menopausal symptoms; Sex hormones

Indexed keywords

ANTIESTROGEN; CIMICIFUGA RACEMOSA EXTRACT; COLLAGEN TYPE 1; ESTRADIOL; ESTROGEN; FOLLITROPIN; GONADOTROPIN; HORMONE; LUTEINIZING HORMONE; OSTEOCALCIN; PHYTOESTROGEN; PROGESTERONE;

ATROPHY; BREAST CANCER; CANCER RISK; CARDIOTOXICITY; CARDIOVASCULAR DISEASE; CELL PROLIFERATION; CLINICAL FEATURE; COCHRANE LIBRARY; DATA BASE; DRUG ACTIVITY; DRUG EFFECT; DRUG FORMULATION; DRUG MECHANISM; EMBASE; EMOTIONAL DISORDER; ENDOMETRIUM CANCER; ESTROGEN ACTIVITY; ESTROGEN SYNTHESIS; ESTRUS CYCLE; HORMONE ACTION; HORMONE SUBSTITUTION; HOT FLUSH; HUMAN; ISCHEMIC HEART DISEASE; LUTEINIZING HORMONE BLOOD LEVEL; MEDLINE; MENOPAUSAL SYNDROME; NONHUMAN; OSTEOPOROSIS; POSTMENOPAUSE; PROGESTERONE SYNTHESIS; PROTEIN EXPRESSION; REDUCTION; SEXUAL DYSFUNCTION; SHORT SURVEY; SIDE EFFECT; SLEEP DISORDER; UTERUS WEIGHT;

ANIMALIA; CAULOPHYLLUM; CIMICIFUGA; CIMICIFUGA DAHURICA; CIMICIFUGA RACEMOSA;

EID: 0038015262     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(03)00378-3     Document Type: Review

References (43)

1. Bergkvist L., Persson I. Hormone replacement therapy and breast cancer. A review of current knowledge. Drug Safety. 15:1996;360-370.
2. Bider D., Mashiach S., Serr D.M., Ben-Rafael Z. Endocrinological basis of hot flushes. Obstetrical and Gynecological Survery. 44:1989;495-499.
3. Borrelli F., Ernst E. Cimicifuga racemosa: A systematic review of its clinical and pharmacological effects. European of Journal Clinical Pharmacology. 2002;. in press.
4. Colao A., Di Somma C., Loche S., Di Sarno A., Klain M., Pivonello R., Pietrosante M., Salvatore M., Lombardi G. Prolactinomas in adolescents: persistent bone loss after 2 years of prolactin normalization. Clinical Endocrinology. 52:2000;319-327.
5. Di Somma C., Colao A., Di Sarno A., Klain M., Landi M.L., Facciolli G., Pivonello R., Panza N., Salvatore M., Lombardi G. Bone marker and bone density responses to dopamine agonist therapy in hyperprolactinemic males. Journal of Clinical Endocrinology and Metabolism. 83:1998;807-813.
6. Dixon Shanies D., Shaikh N. Growth inhibition of human breast cancer cells by herbs and phytoestrogens. Oncology Rep. 6:1999;1383-1387.
7. Duker E.M., Kopanski L., Jarry H., Wuttke W. Effects of extracts from Cimicifuga racemosa on gnadotropin release in menopausal women and ovariectomized rats. Planta Medica. 57:1991;420-424.
8. Eagon C.L., Elm M.S., Eagon P.K. Estrogenicity of traditional Chinese and Western herbal remedies. Proceeding of the American Association for Cancer Research. 37:1996;284.
9. Eagon C.L., Elm M.S., Teepe A.G., Eagon P.K. Medicinal botanicals: Estrogenicity in rat uterus and liver. Proceeding of the American Association for Cancer Research. 38:1997;293.
10. Eagon P.K., Tress N.B., Ayer H.A., Wiese J.M., Henderson T., Elm M.S., Eagon C.L. Medicinal botanicals with hormonal activity. Proceeding of the American Association for Cancer Research. 40:1999;161-162.
11. Einer Jensen N., Zhao J., Andersen K.P., Kristoffersen K. Cimicifuga and Melbrosia lack oestrogenic effects in mice and rats. Maturitas. 25:1996;149-153.
12. Foldes J. The actions of an extract of Cimicifuga racemosa. Arzneimittelforschung. 13:1959;623-624.
13. Foster S. Black cohosh: Cimicifuga racemosa. A literature review. Herbal Gram. 1999;35-50.
14. Freudenstein J., Bodinet C. Influence of an isopropanolic aqueous extract of Cimicifuga racemosa rhizoma on the proliferation of MCF-7 cells. Abstractband 23rd Int LOF-Symposium on Phyto-Oestrogens, University of Gent, Belgium:1999.
15. Freudenstein J., Dasenbrock C., Nisslein T. Lack of promotion of estrogen dependent mammary gland tumors in vivo by an isopropanolic black cohosh extract. Phytomedicine. 7:2000;13.
16. Gizicky H.V. Arzneipflanzen in ihren Beziehungen zum weiblichen Genitalsystem. Versuche an weissen ratten und mausen mit cimicifuga racemosa. Z. Ges. Exp. Med. 113:1944;635-644.
17. Hagels H., Baumert-Krauss J., Freudenstein J. Composition of phenolic constituents in Cimicifuga racemosa. Abstract Inter Congress and 48th Annual Meeting of the Society for Medicinal Plant Research. 6th Inter Congress on Ethnopharmacology of the International Society for Ethnopharmacology, Zurich, Switzerland:2000.
18. Harnischfeger, G., Cillien, N., 1996. Influence of Cimicifuga racemosa extract fractions on the proliferation of human carcinoma cells in vitro with regard to their estrogen receptor sensitivity. 44th Annual Congress of Georg August Universitat, Gottingen, Germany. P12: 40.
19. Jarry H., Harnischfeger G., Duker E. Studies on endocrine effects of the contents of Cimicifuga racemosa 2. In vitro binding of compounds to estrogen receptors. Planta Medica. 51:1985;316-319.
20. Jarry H., Harnischfeger G. Studies on the endocrine effects of the contents of Cimicifuga racemosa: 1. Influence on the serum concentration of pituitary hormones in ovariectomized rats. Planta Medica. 51:1985;46-49.
21. Jarry H., Leonhardt S., Duls C., Popp M., Christoffel V., Spengler B., Theiling K., Wuttke W. Organ-specific effects of Cimicifuga racemosa in brain and uterus. Abstract 23rd Int LOF-Symposium on Phyto-Oestrogens, University of Gent, Belgium:1999.
22. Jarry H., Ludwing M.L., Stephan A., Kuhn U., Christoffel C.V., Wuttke W. Constituents of cimicifuga racemosa exert direct effects on in-vitro ovarian steroid secretion. Abstract 2nd Int Congress on Phytomedicine, Munich, German:1996.
23. Johnson D.E., Ochieng J., Evans S.I. The growth inhibitory properties of a dopamine agonist (SKF 38393) on MCF-7 cells. Anticancer Drugs. 6:1995;471-474.
24. Kass-Annese B. Alternative therapies for menopause. Clinical Obstretics and Gynecology. 43:2000;162-183.
25. Koloszar S., Gellen J., Kovacs L. The value of plasma prolactin level determination in the diagnosis of postmenopausal osteoporosis. Orv Hetil. 138(2):1997;71-73.
26. Kruse S.O., Lohning A., Pauli G.F., Winterhoff H., Nahrstedt A. Fukiic and piscidic acid esters from the rhizome of Cimicifuga racemosa and the in vitro estrogenic activity of fukinolic acid. Planta Medica. 65:1999;763-764.
27. Liu J., Burdette J.E., Xu H., Gu C., Van Breemen R.B., Bhat K.P., Booth N., Constantinou A.I., Pezzuto J.M., Fong H.H., Farnsworth N.R., Bolton J.L. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. Journal Agricultural and Food Chemistry. 49:2001;2472-2479.
28. Liu Z., Yang Z., Zhu M., Huo J. Estrogenicity of black cohosh (Cimicifuga racemosa) and its effect on estrogen receptor level in human cancer MCF-7 cells. Wei Sheng Yan Jiu. 30:2001;77-80.
29. Lohning A., Verspohl E.J., Winterhoff H. Cimicifuga racemosa: In vitro findings using MCF-7 cells. Abstractband Phytopharmakaforschung, Bonn:2000.
30. Lohning A., Verspohl E.J., Winterhoff H. Pharmacological studies on the dopaminergic activity of cimicifuga racemosa. Abstract 23rd Int LOF-Symposium on Phyto-Oestrogens, University of Gent, Belgium:1999.
31. Mckenna D.J., Jones K., Humphrey S., Hughes K. Black Cohosh: efficacy, safety, and use in clinical and preclinical applications. Alternative Therapies. 7:2001;93-100.
32. Mercier F., Balansard J. Sur les contituants du rhizome de Cimicifuga racemosa. Societe de Biologie de Marseille. 118:1935;166-168.
33. Murray, M.T., Pizzorno, J.E., 1999. Menopause. In: Murray, M.T., Pizzorno, J.E., (Eds.), Textbook of Natural Medicine. Churchill Livingstone, Bastry University, Kenmore, Washington pp. 1387-1396.
34. Nesselhut T., Schellhase C., Dietrich R., Kuhn W. Study on the proliferative potential of phytopharmacological agents with estrogen-like effect in breast cancer cells. Archive of Gynecology and Obstetrics. 254:1993;817-818.
35. Nisslein T., Freudenstein J. Effects of black cohosh on urinary bone markers and femoral density in an ovx-rat model. Osteoporosis International abstract. 504:2000.
36. O'Malley B.W., Schrader W.T., Mani S., Smith C., Weigel N.L., Conneely O.M., Clark J.K. An alternative ligand-independent pathway for activation of steroid receptors. Recent Prog Hormonal Research. 50:1995;333-347.
37. Sanfilippo J.S. Implications of not treating hyperprolactinemia. Journal of Reproductive Medicine. 44:1999;1111-1115.
38. Siess M., Seybold G. Untersuchungen uber die Wirkung von Pulsatilla pratensis, Cimicifuga racemosa und Aristolochia clematitis auf den Ostrus infantiler und kastrierter weisser mause. Azneimittel-Forschung. 10:1960;514-520.
39. Struck D., Tegtmeier M., Harnischfeger G. Flavones in extracts of Cimicifuga racemosa. Planta Medica. 63:1997;289.
40. Tsai M.J., O'Malley B.W. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annual Review of Biochemistry. 63:1994;451-486.
41. Webster J. A comparative review of the tolerability profiles of dopamine agonists in the treatment of hyperprolactinaemia and inhibition of lactation. Drug Saf. 14:1996;228-238.
42. Whitehead M.I., Townsend P.T., Davies-Pryse J., Ryder T.A., King R.J. Effects of estrogens and progestins on the biochemistry and morphology of the postmenopausal endometrium. New Engl J Med. 305:1981;1599-1685.
43. Zava D.T., Dollbaum C.M., Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med. 217:1998;369-378.