Role of orexins in the hypothalamic-pituitary-ovarian relationships

Acta Physiologica

Volumn 198, Issue 3, 2010, Pages 355-360

  Silveyra, P ^a   Cataldi, N I ^a   Lux Lantos, V A ^a   Libertun, C ^a,b  

^a INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Cycle; Hypothalamus; Ovary; Pituitary; Prepro orexin; Receptors

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; CETRORELIX; ESTRADIOL; FOLLITROPIN; HORMONE RECEPTOR BLOCKING AGENT; JNJ 10397049; LUTEINIZING HORMONE; MESSENGER RNA; OREXIN; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; PENTOBARBITAL; PROGESTERONE; PROLACTIN; SB 334867 A; UNCLASSIFIED DRUG;

ADENOHYPOPHYSIS; ALERTNESS; BRAIN REGION; CONFERENCE PAPER; ENERGY BALANCE; ESTRUS CYCLE; FOLLITROPIN RELEASE; FOOD INTAKE; GENE EXPRESSION REGULATION; GONADOTROPIN RELEASE; HORMONE ACTION; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS HYPOPHYSIS OVARY SYSTEM; LIGHT DARK CYCLE; LUTEINIZING HORMONE RELEASE; NONHUMAN; OVULATION; PRIORITY JOURNAL; PROESTRUS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPRODUCTION; SLEEP WAKING CYCLE;

ANIMALS; AROUSAL; BIOLOGICAL CLOCKS; EATING; ENERGY METABOLISM; ESTRADIOL; ESTRUS; FEMALE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; OVARY; PITUITARY GLAND, ANTERIOR; PROESTRUS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; REPRODUCTION;

EID: 75749100589     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2009.02049.x     Document Type: Conference Paper

References (46)

1. Ammoun, S., Holmqvist, T., Shariatmadari, R., Oonk, H.B., Detheux, M., Parmentier, M., Akerman, K.E. Kukkonen, J.P. 2003. Distinct recognition of OX1 and OX2 receptors by orexin peptides. J Pharmacol Exp Ther 305, 507 514.
2. Baumann, C.R. Bassetti, C.L. 2005. Hypocretins (orexins) and sleep-wake disorders. Lancet Neurol 4, 673 682.
3. Blanco, M., Lopez, M., Garcia-Caballero, T., Gallego, R., Vazquez-Boquete, A., Morel, G., Senaris, R., Casanueva, F., Dieguez, C. Beiras, A. 2001. Cellular localization of orexin receptors in human pituitary. J Clin Endocrinol Metab 86, 1616 1619. (Pubitemid 32374913)
4. Brogan, R.S., Grove, K.L. Smith, M.S. 2000. Differential regulation of leptin receptor but not orexin in the hypothalamus of the lactating rat. J Neuroendocrinol 12, 1077 1086.
5. Buffenstein, R., Poppitt, S.D., McDevitt, R.M. Prentice, A.M. 1995. Food intake and the menstrual cycle: a retrospective analysis, with implications for appetite research. Physiol Behav 58, 1067 1077.
6. Cai, X.J., Denis, R., Vernon, R.G., Clapham, J.C., Wilson, S., Arch, J.R. Williams, G. 2001. Food restriction selectively increases hypothalamic orexin-B levels in lactating rats. Regul Pept 97, 163 168.
7. Campbell, R.E., Grove, K.L. Smith, M.S. 2003. Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibers. Endocrinology 144, 1542 1548.
8. Cluderay, J.E., Harrison, D.C. Hervieu, G.J. 2002. Protein distribution of the orexin-2 receptor in the rat central nervous system. Regul Pept 104, 131 144.
9. Dye, L. Blundell, J.E. 1997. Menstrual cycle and appetite control: implications for weight regulation. Hum Reprod 12, 1142 1151.
10. Furuta, M., Funabashi, T. Kimura, F. 2002. Suppressive action of orexin A on pulsatile luteinizing hormone secretion is potentiated by a low dose of estrogen in ovariectomized rats. Neuroendocrinology 75, 151 157.
11. Garcia, M.C., Lopez, M., Gualillo, O., Seoane, L.M., Dieguez, C. Senaris, R.M. 2003. Hypothalamic levels of NPY, MCH, and prepro-orexin mRNA during pregnancy and lactation in the rat: role of prolactin. FASEB J 17, 1392 1400.
12. Greco, M.A. Shiromani, P.J. 2001. Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats. Brain Res Mol Brain Res 88, 176 182.
13. Hervieu, G.J., Cluderay, J.E., Harrison, D.C., Roberts, J.C. Leslie, R.A. 2001. Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord. Neuroscience 103, 777 797.
14. Iqbal, J., Pompolo, S., Sakurai, T. Clarke, I.J. 2001. Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus. J Neuroendocrinol 13, 1033 1041.
15. Irahara, M., Tamura, T., Matuzaki, T., Saito, S., Yasui, T., Yamano, S., Kamada, M. Aono, T. 2001. Orexin-A suppresses the pulsatile secretion of luteinizing hormone via beta-endorphin. Biochem Biophys Res Commun 281, 232 236.
16. Jaszberenyi, M., Bujdoso, E., Pataki, I. Telegdy, G. 2000. Effects of orexins on the hypothalamic-pituitary-adrenal system. J Neuroendocrinol 12, 1174 1178.
17. Johren, O., Neidert, S.J., Kummer, M., Dendorfer, A. Dominiak, P. 2001. Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats. Endocrinology 142, 3324 3331.
18. Johren, O., Bruggemann, N., Dendorfer, A. Dominiak, P. 2003. Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptors. Endocrinology 144, 1219 1225.
19. Kalra, S.P. 1997. Appetite and body weight regulation: is it all in the brain? Neuron 19, 227 230.
20. Kalra, S.P., Dube, M.G., Pu, S., Xu, B., Horvath, T.L. Kalra, P.S. 1999. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20, 68 100.
21. Kanenishi, K., Ueno, M., Momose, S., Kuwabara, H., Tanaka, H., Sato, C., Kobayashi, T., Hino, O., Sakamoto, H. Hata, T. 2004. Prepro-orexin mRNA expression in the rat brain is increased during pregnancy. Neurosci Lett 368, 73 77.
22. Kohsaka, A., Watanobe, H., Kakizaki, Y., Suda, T. Schioth, H.B. 2001. A significant participation of orexin-A, a potent orexigenic peptide, in the preovulatory luteinizing hormone and prolactin surges in the rat. Brain Res 898, 166 170.
23. Kok, S.W., Roelfsema, F., Overeem, S., Lammers, G.J., Frolich, M., Meinders, A.E. Pijl, H. 2004. Pulsatile LH release is diminished, whereas FSH secretion is normal, in hypocretin-deficient narcoleptic men. Am J Physiol Endocrinol Metab 287, E630 E636.
24. de Lecea, L., Kilduff, T.S., Peyron, C., Gao, X., Foye, P.E., Danielson, P.E., Fukuhara, C., Battenberg, E.L., Gautvik, V.T., Bartlett, F.S., 2nd., Frankel, W.N., van den Pol, A.N., Bloom, F.E., Gautvik, K.M. Sutcliffe, J.G. 1998. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95, 322 327.
25. Lu, X.Y., Bagnol, D., Burke, S., Akil, H. Watson, S.J. 2000. Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Horm Behav 37, 335 344.
26. Nagai, K., Nishio, T., Nakagawa, H., Nakamura, S. Fukuda, Y. 1978. Effect of bilateral lesions of the suprachiasmatic nuclei on the circadian rhythm of food-intake. Brain Res 142, 384 389.
27. Navarro, V.M., Fernandez-Fernandez, R., Nogueiras, R., Vigo, E., Tovar, S., Chartrel, N., Le Marec, O., Leprince, J., Aguilar, E., Pinilla, L., Dieguez, C., Vaudry, H. Tena-Sempere, M. 2006. Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis. J Physiol 573, 237 249.
28. Peyron, C., Tighe, D.K., van den Pol, A.N., de Lecea, L., Heller, H.C., Sutcliffe, J.G. Kilduff, T.S. 1998. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18, 9996 10015.
29. Porkka-Heiskanen, T., Kalinchuk, A., Alanko, L., Huhtaniemi, I. Stenberg, D. 2004. Orexin A and B levels in the hypothalamus of female rats: the effects of the estrous cycle and age. Eur J Endocrinol 150, 737 742.
30. Pu, S., Jain, M.R., Kalra, P.S. Kalra, S.P. 1998. Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Regul Pept 78, 133 136.
31. Rocha, M., Bing, C., Williams, G. Puerta, M. 2003. Pregnancy-induced hyperphagia is associated with increased gene expression of hypothalamic agouti-related peptide in rats. Regul Pept 114, 159 165.
32. Russell, S.H., Small, C.J., Kennedy, A.R., Stanley, S.A., Seth, A., Murphy, K.G., Taheri, S., Ghatei, M.A. Bloom, S.R. 2001. Orexin A interactions in the hypothalamo-pituitary gonadal axis. Endocrinology 142, 5294 5302.
33. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richarson, J.A., Kozlowski, G.P., Wilson, S. et al. 1998. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 1 page following 696.
34. Sasson, R., Dearth, R.K., White, R.S., Chappell, P.E. Mellon, P.L. 2006. Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons. Neuroendocrinology 84, 353 363.
35. Silveyra, P., Catalano, P.N., Lux-Lantos, V. Libertun, C. 2007a. Impact of proestrous milieu on expression of orexin receptors and prepro-orexin in rat hypothalamus and hypophysis: actions of Cetrorelix and Nembutal. Am J Physiol Endocrinol Metab 292, E820 E828.
36. Silveyra, P., Lux-Lantos, V. Libertun, C. 2007b. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. Am J Physiol Endocrinol Metab 293, E977 E985.
37. Silveyra, P., Cataldi, N., Lux-Lantos, V. Libertun, C. 2008. Estradiol modulates female hypothalamic and pituitary orexin receptor 1 expression in a daytime dependent manner. 90th Annual Meeting, P1 P730. The Endocrine Society (USA), San Francisco, CA. Abstract book.
38. Small, C.J., Goubillon, M.L., Murray, J.F., Siddiqui, A., Grimshaw, S.E., Young, H., Sivanesan, V., Kalamatianos, T., Kennedy, A.R., Coen, C.W., Bloom, S.R. Wilson, C.A. 2003. Central orexin A has site-specific effects on luteinizing hormone release in female rats. Endocrinology 144, 3225 3236.
39. Smart, D. 1999. Orexins: a new family of neuropeptides. Br J Anaesth 83, 695 697.
40. Smart, D. Jerman, J. 2002. The physiology and pharmacology of the orexins. Pharmacol Ther 94, 51 61.
41. Soffin, E.M., Gill, C.H., Brough, S.J., Jerman, J.C. Davies, C.H. 2004. Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus. Neuropharmacology 46, 1168 1176.
42. Tamura, T., Irahara, M., Tezuka, M., Kiyokawa, M. Aono, T. 1999. Orexins, orexigenic hypothalamic neuropeptides, suppress the pulsatile secretion of luteinizing hormone in ovariectomized female rats. Biochem Biophys Res Commun 264, 759 762.
43. Trivedi, P., Yu, H., MacNeil, D.J., Van der Ploeg, L.H. Guan, X.M. 1998. Distribution of orexin receptor mRNA in the rat brain. FEBS Lett 438, 71 75.
44. Turek, F.W., Losee-Olson, S., Swann, J.M., Horwath, K., Van Cauter, E. Milette, J.J. 1987. Circadian and seasonal control of neuroendocrine-gonadal activity. J Steroid Biochem 27, 573 579.
45. Wang, J.B., Murata, T., Narita, K., Honda, K. Higuchi, T. 2003. Variation in the expression of orexin and orexin receptors in the rat hypothalamus during the estrous cycle, pregnancy, parturition, and lactation. Endocrine 22, 127 134.
46. Yang, Y., Zhou, L.B., Liu, S.Q., Tang, J.F., Li, F.Y., Li, R.Y., Song, H.D. Chen, M.D. 2005. Expression of feeding-related peptide receptors mRNA in GT1-7 cell line and roles of leptin and orexins in control of GnRH secretion. Acta Pharmacol Sin 26, 976 981.