Blimp-1: A marker of terminal differentiation but not of sebocytic progenitor cells: A comparative analysis of embryonic and adult human skin with sebaceous neoplasms

Journal of Cutaneous Pathology

Volumn 37, Issue 3, 2010, Pages 362-370

  Sellheyer, Klaus ^a,b   Krahl, Dieter ^c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b Nelson Dermatopathology Associates   (United States)

^c Institut fur Dermatohistologie   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PRDM1 PROTEIN, HUMAN; REPRESSOR PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; HAIR FOLLICLE; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; NAIL; PHYSIOLOGY; PRENATAL DEVELOPMENT; SEBACEOUS GLAND; STEM CELL;

CELL DIFFERENTIATION; CELL LINEAGE; HAIR FOLLICLE; HUMANS; IMMUNOHISTOCHEMISTRY; NAILS; REPRESSOR PROTEINS; SEBACEOUS GLANDS; STEM CELLS;

EID: 75749098929     PISSN: 03036987     EISSN: 16000560     Source Type: Journal    
DOI: 10.1111/j.1600-0560.2009.01434.x     Document Type: Article

References (26)

1. Downing DT, Strauss JS. On the mechanism of sebaceous secretion. Arch Dermatol Res 1982 272 : 343.
2. Zouboulis CC, Baron JM, Böhm M, et al. Frontiers in sebaceous gland biology and pathology. Exp Dermatol 2008 17 : 542.
3. Panteleyev AA, Rosenbach T, Paus R, Christiano AM. The bulge is the source of cellular renewal in the sebaceous gland of mouse skArch Dermatol Res 2000 292 : 573.
4. Taylor G, Lehrer MS, Jensen PJ, et al. Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell 2000 102 : 451.
5. Oshima H, Rochat A, Kedzia C, et al. Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell 2001 104 : 233.
6. Blanpain C, Lowry WE, Geoghegan A, et al. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 2004 118 : 635.
7. Lo Celso C, Berta MA, Braun KM, et al. Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenStem Cells 2008 26 : 1241.
8. Gat U, DasGupta R, Degenstein L, Fuchs E. De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skCell 1998 95 : 605.
9. Niemann C, Owens DM, Hülsken J, et al. Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. Development 2002 129 : 95.
10. Niemann C, Unden AB, Lyle S, et al. Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Proc Natl Acad Sci USA 2003 100 (Suppl. 1) : 11873.
11. Horsley V, O'Carroll D, Tooze R, et al. Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell 2006 126 : 597.
12. Turner CA Jr., Mack DH, Davis MM. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 1994 77 : 297.
13. Ohinata Y, Payer B, O'Carroll D, et al. Blimp1 is a critical determinant of the germ cell lineage in mice. Nature 2005 436 : 207.
14. Baxendale S, Davison C, Muxworthy C, et al. The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling. Nat Genet 2004 36 : 88.
15. Baran R, Dawber RP, Haneke E. Hair and nail relationship. Skinmed 2005 4 : 18.
16. Mercer BM, Sklar S, Shariatmadar A, et al. Fetal foot length as a predictor of gestational age. Am J Obstet Gynecol 1987 156 : 350.
17. Drey EA, Kang MS, McFarland W, Darney PD. Improving the accuracy of fetal foot length to confirm gestational duration. Obstet Gynecol 2005 105 : 773.
18. Hashimoto K. The ultrastructure of the skin of human embryos. IX. Formation of the hair cone and intraepidermal hair canal. Arch Klin Exp Dermatol 1970 238 : 333.
19. Holbrook KA, Fisher C, Dale BA, Hartley R. Morphogenesis of the hair follicle during the ontogeny of human skIn Rogers GE, Reis PJ, Ward KA, Marshall RC, eds. The biology of wool and hair. London, New York : Chapman & Hall, 1989 15.
20. Chang DH, Calame KL. The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development. Mech Dev 2002 117 : 305.
21. Robertson EJ, Charatsi I, Joyner CJ, et al. Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. Development 2007 134 : 4335.
22. Magnúsdóttir E, Kalachikov S, Mizukoshi K, et al. Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1. Proc Natl Acad Sci USA 2007 104 : 14988.
23. Shipitsin M, Polyak K. The cancer stem cell hypothesis: in search of definitions, markers, and relevance. Lab Invest 2008 88 : 459.
24. Arnold I, Watt FM. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol 2001 11 : 558.
25. Waikel RL, Kawachi Y, Waikel PA, et al. Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet 2001 28 : 165.
26. Bull JJ, Pelengaris S, Hendrix S, et al. Ectopic expression of c-Myc in the skin affects the hair growth cycle and causes an enlargement of the sebaceous gland. Br J Dermatol 2005 152 : 1125.