Ectopic expression of c-Myc in the skin affects the hair growth cycle and causes an enlargement of the sebaceous gland

British Journal of Dermatology

Volumn 152, Issue 6, 2005, Pages 1125-1133

  Bull, J J ^a   Pelengaris, S ^b   Hendrix, S ^c   Chronnell, C M T ^a   Khan, M ^b   Philpott, M P ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

c Myc; Hair follicle; Sebaceous gland; Transgenic mouse

Indexed keywords

MYC PROTEIN; ONCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EPIDERMIS; GENE ACTIVATION; GENE EXPRESSION; HAIR GROWTH; KERATINOCYTE; MOUSE; NONHUMAN; ONCOGENE C MYC; PHENOTYPE; PRIORITY JOURNAL; SEBACEOUS GLAND; SKIN; SKINFOLD THICKNESS; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; BIOLOGICAL MARKERS; CELL PROLIFERATION; EPIDERMIS; ESTROGEN ANTAGONISTS; GENE EXPRESSION; GENES, MYC; HAIR; HAIR FOLLICLE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-MYC; SCALP; SEBACEOUS GLANDS; TAMOXIFEN;

EID: 21644479378     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2005.06458.x     Document Type: Article

References (38)

1. Müller-Röver S, Handjiski B, van der Veen C et al. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol 2001; 117:3-15.
2. Stenn KS, Paus R. Controls of hair follicle cycling. Physiol Rev 2001; 81:449-94.
3. Paus R, Müller-Röver S, Botchkarev VA. Chronobiology of the hair follicle: the 'Hair Cycle Clock'. J Invest Dermatol Symp Proc 1999; 4:338-45.
4. Taylor G, Lehrer MS, Jensen PJ et al. Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell 2000; 102:451-61.
5. Lavker RM, Miller S, Cotsarelis G et al. Hair follicle stem cells: their location, role in hair cycle and involvement in skin tumour formation. J Invest Dermatol 1993; 101:S16-S26.
6. Oster SK, Ho CS, Soucie EL et al. The myc oncogene: marvelously complex. Adv Cancer Res 2002; 84:81-154.
7. Grandori C, Cowley SM, James LP et al. The Myc/Max/Mad network and the transcriptional control of cell behavior. Amu Rev Cell Dev Biol 2000; 16:653-99.
8. Pelengaris S, Khan M, Evan GI. Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 2002; 109:321-34.
9. Waikel RL, Kawachi Y, Waikel PA et al. Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet 2001; 28:165-8.
10. Waikel RL, Wang X-J, Roop DR. Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis. Oncogene 1999; 18:4870-8.
11. Pelengaris S, Littlewood T, Khan M et al. Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol Cell 1999; 3:565-77.
12. Arnold I, Watt FM. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol 2001; 11:558-68.
13. Gandarillas A, Watt FM. c-Myc promotes differentiation of human epidermal stem cells. Genes Dev 1997; 11:2869-82.
14. Bull JJ, Müller-Röver S, Patel SV et al. Contrasting localization of c-Myc with other Myc superfamily transcription factors in the human hair follicle and during the hair growth cycle. J Invest Dermatol 2001; 116:617-22.
15. Oshima H, Rochat A, Kedzia C et al. Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell 2001; 104:233-45.
16. Cotsarelis G, Sun T-T, Lavker RM. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 1990; 61:1329-37.
17. Lyle S, Christofidou-Solomidou M, Liu Y et al. The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci 1998; 111:3179-88.
18. Littlewood TD, Hancock DC, Danielian PS et al. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucl Acids Res 1995; 23:1686-90.
19. Carroll JM, Albers KM, Garlick JA et al. Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice. Proc Natl Acad Sci USA 1993; 90:10270-4.
20. Paus R, Müller-Röver S, van der Veen C et al. A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. J Invest Dermatol 1999; 113:523-32.
21. Handjiski BK, Eichmuller S, Hofmann U et al. Alkaline phosphatase activity and localization during the murine hair cycle. Br J Dermatol 1994; 131:303-10.
22. Moore JP, Hancock DC, Littlewood TD et al. A sensitive and quantitative enzyme-linked immunosorbence assay for the c-myc and N-myc oncoproteins. Oncogene Res 1987; 2:65-80.
23. Lindner G, Botchkarev VA, Botchkarev NV et al. Analysis of apoptosis during hair follicle regression (catagen). Am J Pathol 1997; 151:1601-17.
24. Xia LQ, Zouboulis C, Detmar M et al. Isolation of human sebaceous glands and cultivation of sebaceous gland-derived cells as an in vitro model. J Invest Dermatol 1989; 93:315-21.
25. Chanda S, Robinette CL, Couse JF et al. 17β-estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen-α pathway. Am J Physiol Endocrinol Metab 2000; 278:E202-10.
26. Arias NH, Houssay AB, Pieretti SA. Effects of cyproterone and tamoxifen upon the hair waves in mice. Acta Physiol Lot Am 1982; 32:261-6.
27. Niemann C, Unden AB, Lyle S et al. Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Proc Natl Acad Sci USA 2003; 100 (Suppl. 1): 11873-80.
28. Allen M, Grachtchouk M, Sheng H et al. Hedgehog signaling regulates sebaceous gland development. Am J Pathol 2003; 163:2173-8.
29. Braun KM, Niemann C, Jensen UB et al. Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development 2003; 130:5241-55.
30. Merrill BJ, Gat U, DasGupta R et al. Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev 2001; 15:1688-705.
31. He T-C, Sparks AB, Rago C et al. Identification of C-MYC as a target of the APC pathway. Science 1998; 281:1509-12.
32. van Mater D, Kolligs FT, Dlugosz AA et al. Transient activation of β-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of hair cycle in mice. Genes Dev 2003; 17:1219-24.
33. Panteleyev AA, Jahoda CAB, Christiano AM. Hair follicle predetermination. J Cell Sci 2001; 114:3419-31.
34. Paus R. Control of the hair cycle and hair diseases as cycling disorders. Curr Opin Dermatol 1996; 3:248-58.
35. Chan EF, Gat U, McNiff JM et al. A common human skin tumour is caused by activating mutations in β-catenin. Nat Genet 1999; 21:410-13.
36. Kam E, Hodgins MB. Communication compartments in hair follicles and their implication in differentiative control. Development 1992; 114:389-93.
37. Guy R, Kealey T. The effects of inflammatory cytokines on the isolated human sebaceous infundibulum. J Invest Dermatol 1998; 110:410-15.
38. Panteleyev AA, Rosenbach T, Paus R et al. The bulge is a source of cellular renewal in the sebaceous gland of mouse skin. Arch Dermatol Res 2000; 292:573-6.