Evaluation of the activity of antimicrobial agents against Legionella pneumophila multiplying in a human monocytic cell line, THP-1, and an alveolar epithelial cell line, A549

Journal of Infection and Chemotherapy

Volumn 6, Issue 4, 2000, Pages 206-210

  Kunishima, H ^a   Takemura, H ^a   Yamamoto, H ^a   Kanemitsu, K ^a   Shimada, J ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

A549; Alveolar epithelial cell; Intracellular activity; Legionella pneumophila; Macrophage; THP 1

Indexed keywords

ANTIINFECTIVE AGENT; CIPROFLOXACIN; CLARITHROMYCIN; ERYTHROMYCIN;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CELL LINE; CONTROLLED STUDY; HOST CELL; HUMAN; HUMAN CELL; LEGIONELLA PNEUMOPHILA; LUNG ALVEOLUS EPITHELIUM; MINIMUM INHIBITORY CONCENTRATION; MONOCYTE; NONHUMAN;

EID: 0034526844     PISSN: 1341321X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s101560070004     Document Type: Article

References (15)

1. Legionella pneumophila: A cause of severe community-acquired pneumonia
2. Legionella pneumophila replicates in rat alveolar epithelial cells
3. Ultrastructure of Legionella pneumophila
4. Entry and intracellular growth of Legionella dumoffii in alveolar epithelial cells
5. Comparative postantibacterial activities of pefloxacin, ciprofloxacin, and ofloxacin against intracellular multiplication of Legionella pneumophila serogroup 1
6. Growth of Legionella pneumophila in a human macrophage-like (U937) cell line
7. Susceptibility of Legionella pneumophila to eight antimicrobial agents including four macrolides under different assay conditions
8. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1)
9. Inhibitory and bactericidal activities of levofloxacin, ofloxacin, erythromycin, and rifampicin used singly and in combination against Legionella pneumophila
10. Inhibition of Legionella pneumophila multiplication in human macrophages by antimicrobial agents
11. High-performance liquid chromatography measurement of antimicrobial concentrations in polymorphonuclear leukocytes
12. Requirements for intracellular accumulation and release of clarithromycin and azithromycin by human phagocytes
13. Comparative uptake of sparfloxacin and ciprofloxacin into human THP-1 monocytic cells
14. Apoptosis in macrophages and alveolar epithelial cells during early stages of infection by Legionella pneumophila and its role in cytopathogenicity
15. Penetration of macrolides into human polymorphonuclear leucocytes