Evaluation of NAD(H) analogues as selective inhibitors for trypanosoma cruzi S-adenosylhomocysteine hydrolase

Nucleosides, Nucleotides and Nucleic Acids

Volumn 28, Issue 5-7, 2009, Pages 473-484

  Li, Qing Shan ^a   Cai, Sumin ^a   Fang, Jianwen ^a   Borchardt, Ronald T ^a   Kuczera, Krzysztof ^a   Middaugh, C Russell ^a   Schowen, Richard L ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Anti parasitic drugs; Cofactor site targeting; Enzyme inhibitors; S adenosylhomocysteine hydrolase

Indexed keywords

3 ACETYLPYRIDINE ADENINE DINUCLEOTIDE; 3 PYRIDINEALDEHYDE ADENINE DINUCLEOTIDE; ADENOSYLHOMOCYSTEINASE; ADENOSYLHOMOCYSTEINASE INHIBITOR; ANTITRYPANOSOMAL AGENT; DINUCLEOTIDE; NICOTINAMIDE 1, N6 ETHENOADENINE DINUCLEOTIDE; NICOTINAMIDE GUANINE DINUCLEOTIDE; NICOTINAMIDE HYPOXANTHINE DINUCLEOTIDE; NICOTINIC ACID ADENINE DINUCLEOTIDE; REDUCED 3 ACETYLPYRIDINE ADENINE DINUCLEOTIDE; REDUCED 3 PYRIDINEALDEHYDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE HYPOXANTHINE DINUCLEOTIDE; REDUCED THIONICOTINAMIDE ADENINE DINUCLEOTIDE; THIONICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SPECIFICITY; PROTEIN EXPRESSION; TRYPANOSOMA CRUZI;

ADENOSYLHOMOCYSTEINASE; CHAGAS DISEASE; HUMANS; NAD; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 75749085215     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770903044572     Document Type: Article

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