Dynamics of micronuclei in mouse skin fibroblasts after gamma irradiation

Health Physics

Volumn 98, Issue 2, 2010, Pages 228-233

  Kaspler, Pavel ^a   Hyrien, Ollivier ^b   Hill, Richard P ^a,c  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF ROCHESTER   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Accidents, nuclear; Biological indicators; Gamma radiation; Mice

Indexed keywords

MUS;

ANIMAL; ARTICLE; C3H MOUSE; C57BL MOUSE; CYTOLOGY; FEMALE; FIBROBLAST; FUNCTIONS OF THE SKIN AND ITS APPENDAGES; GAMMA RADIATION; MALE; METHODOLOGY; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; PHYSIOLOGY; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FIBROBLASTS; GAMMA RAYS; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; RADIATION DOSAGE; SKIN PHYSIOLOGICAL PHENOMENA;

EID: 75649144989     PISSN: 00179078     EISSN: None     Source Type: Journal    
DOI: 10.1097/HP.0b013e3181b02f90     Document Type: Article

References (12)

1. Fenech M. The in vitro micronucleus technique. Mutat Res 455:81-95; 2000.
2. Hill RP, Kaspler P, Griffin AM, O'Sullivan B, Catton C, Alasti H, Abbas A, Heydarian M, Ferguson P, Wunder JS, Bell RS. Studies of the in vivo radiosensitivity of human skin fibroblasts. Radiother Oncol 84:75- 83; 2007.
3. International Atomic Energy Agency. Cytogenetic analysis for radiation dose assessment: a manual. Vienna: IAEA; Technical Report Series No. 405; 2001.
4. Kanda R, Eguchi-Kasai K, Itsukaichi H, Mori M, Hayata I. Chemically induced premature chromosome condensation in human fibroblast cell lines: fundamental study for applications to the biodosimetry of local exposure. Somat Cell Mol Genet 25:317-325; 1999.
5. Kaspler P, Pintilie M, Hill RP. Dynamics of micronuclei in rat skin fibroblasts after x-ray irradiation. Radiat Res 172:106- 113; 2009.
6. Lee T-K, Wiley AL, Esinhart JD, Blackburn LD. Radiation dose-dependent variations of micronuclei production in cytochalasin B-blocked human lymphocytes. Teratogenesis, Carcinogenesis, and Mutagenesis 14:1-12; 1994.
7. Mill AJ, Wells J, Hall SC, Butler A. Micronucleus induction in human lymphocytes: comparative effects of x-rays, alpha particles, beta particles, and neutrons and implications for biological dosimetry. Radiat Res 145:575-585; 1996.
8. Potten CS. Biological dosimetry of local radiation accidents of skin: possible cytological and biochemical methods. Br J Radiol Suppl 19:82- 85; 1986.
9. Pouget JP, Laurent C, Delbos M, Benderitter M, Clairand I, Trompier F, Stéphanazzi J, Carsin H, Lambert F, Voisin P, Gourmelon P. PCC-FISH in skin fibroblasts for local dose assessment: biodosimetric analysis of a victim of the Georgian radiological accident. Radiat Res 162:365-376; 2004.
10. Senthamizhchelvan S, Pant GS, Rath GK, Julka PK, Nair O. Biodosimetry using micronucleus assay in acute partial body therapeutic irradiation. Phys Med 25:82- 87; 2008.
11. Straume T, Amundson SA, Blakely WF, Burns FJ, Chen A, Dainiak N, Franklin S, Leary JA, Loftus DJ, Morgan WF, Pellmar TC, Stolc V, Turteltaub KW, Vaughan AT, Vijayakumar S, Wyrobek AJ. NASA Radiation Biomarker Workshop, September 27-28, 2007. Radiat Res 170:393- 405; 2008.
12. Zoetelief J, Broerse JJ. Dosimetry for radiation accidents: present status and prospects for biological dosemeters. Int J Radiat Biol 57:737-750; 1990.