Effect of continuous infusion of asialoerythropoietin on short-term changes in infarct volume, penumbra apoptosis and behaviour following middle cerebral artery occlusion in rats

Clinical and Experimental Pharmacology and Physiology

Volumn 37, Issue 2, 2010, Pages 185-192

  Price, Chrystal D ^a   Yang, Zhongjin ^b   Karlnoski, Rachel ^a   Kumar, Dipak ^a   Chaparro, Raphael ^a   Camporesi, Enrico M ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

Apoptosis; Asialoerythropoietin; Infarct volume; Ischaemia reperfusion brain injury; Minipump

Indexed keywords

ASIALOERYTHROPOIETIN; CASPASE 3; CASPASE 9; NEUROPROTECTIVE AGENT; RECOMBINANT ERYTHROPOIETIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID ANALYSIS; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; LOW DRUG DOSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NICK END LABELING; NONHUMAN; RAT; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; ASIALOGLYCOPROTEINS; BRAIN ISCHEMIA; CASPASE 3; CASPASE 9; CEREBRAL INFARCTION; ERYTHROPOIETIN; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 75649142879     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2009.05257.x     Document Type: Article

References (38)

1. Fisher M. The ischemic penumbra: A new opportunity for neuroprotection. Cerebrovasc. Dis. Suppl. 2006 2 : 64 70.
2. Sairanen T, Karjalainen-Lindsberg M-L, Paetau A, Ijas P, Lindsberg PJ. Apoptosis dominant in the periinfarct area of human ischaemic stroke: A possible target of antiapoptotic treatments. Brain 2006 129 : 189 199.
3. Lykissas MG, Korompilias AV, Vekris MD, Mitsionis GI, Sakellariou E, Beris AE. The role of erythropoietin in central and peripheral nerve injury. ClNeurol. Neurosurg. 2007 109 : 639 644.
4. Brines ML, Ghezzi P, Keenan S et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc. Natl Acad. Sci. USA 2000 97 : 10526 10531.
5. Chong Z, Lin S, Kang J, Maiese K. Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and, 8. J. Neurosci. Res. 2003 71 : 659 669.
6. Ehrenreich H, Hasselblatt M, Dembowski C et al. Erythropoietin therapy for acute stroke is both safe and beneficial. Mol. Med. 2002 8 : 495 505.
7. Erbayraktar S, Grasso G, Sfacteria A et al. Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc. Natl Acad. Sci. USA 2003 100 : 6741 6746.
8. Longa E, Weinstein P, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989 20 : 84 91.
9. Wang JP, Yang X, Camporesi CV et al. Propofol reduces infarct size and striatal dopamine accumulation following transient middle cerebral artery occlusion: A microdialysis study. Eur. J. Pharmacol. 2002 452 : 303 308.
10. Yang ZJ, Camporesi C, Yang X et al. Hyperbaric oxygenation mitigates focal cerebral injury and reduces striatal dopamine release in a rat model of transient middle cerebral artery occlusion. Eur. J. Appl. Physiol. 2002 87 : 101 107.
11. Yang ZJ, Meguid MM, Chai JK, Chen C, Oler A. Bilateral hypothalamic dopamine infusion in male Zucker rat suppresses feeding due to reduced meal size. Pharmacol. Biochem. Behav. 1997 58 : 631 635.
12. Frankmann SP. A technique for repeated sampling of CSF from the anesthetized rat. Physiol. Behav. 1986 37 : 489 493.
13. Hunter AJ, Hatcher J, Virely D et al. Functional assessments in mice and rats after focal stroke. Neuropharmacology 2000 39 : 806 816.
14. Lin TN, He YY, Wu G, Khan M, Hsu CY. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 1993 24 : 117 121.
15. Nedergaard M. Neuronal injury in the infarct border: A neuropathological study in the rat. Acta Neuropathol. 1987 73 : 267 274.
16. Meguid MM, Yang ZJ, Ratto C et al. Dynamics of oral intake resumption after general anesthesia and operation in rats. Physiol. Behav. 1992 52 : 597 601.
17. Dittmar M, Spruss T, Schuierer G, Horn M. External carotid artery territory ischemia impairs outcome in the endovascular filament model of middle cerebral artery occlusion in rats. Stroke 2003 34 : 2252 2257.
18. Wiessner C, Allegrini PR, Ekatodramis D, Jewell UR, Stallmach T, Gassmann M. Increased cerebral infarct volumes in polyglobulic mice overexpressing erythropoietJ. Cereb. Blood Flow Metab. 2001 21 : 857 864.
19. Wang L, Zhang Z, Wang Y, Zhang R, Chopp M. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke 2004 35 : 1732 1737.
20. Dubois-Dauphin M, Pfister Y, Vallet PG, Savioz A. Prevention of apoptotic neuronal death by controlling procaspases? A point of view. Brain Res. Brain Res. Rev. 2001 36 : 196 203.
21. Yang ZJ, Hartley CE, Varma M, Middleton F. Erythropoietin reduces traumatic brain injury associated with increased expression of anti-apoptosis genes and decreased expression of pro-apoptosis genes. Anesthesiology 2006 105 : A286 (Abstract).
22. Calapai G, Marciano MC, Corica F et al. Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation. Eur. J. Pharmacol. 2000 401 : 349 356.
23. Prass K, Scharff A, Ruscher K et al. Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietStroke 2003 34 : 1981 1986.
24. Digicaylioglu M, Lipton SA. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signaling cascades. Nature 2001 412 : 641 647.
25. Siren A, Fratelli M, Brines M et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc. Natl Acad. Sci. USA 2001 98 : 4044 4049.
26. Villa P, Bigini P, Mennini T et al. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J. Exp. Med. 2003 198 : 971 975.
27. Shang Y, Wu Y, Yao S, Wang X, Feng D, Yang W. Protective effect of erythropoietin against ketamine-induced apoptosis in cultured rat cortical neurons. Involvement of PI3K/Akt and GSK-3beta pathway. Apoptosis 2007 12 : 2187 2195.
28. Wu Y, Shang Y, Sun S, Liang H, Liu R. Erythropoietin prevents PC12 cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis via the Akt/Gsk-3beta/caspase-3 mediated signaling pathway. Apoptosis 2007 12 : 1365 1375.
29. Robinson RG, Shoemaker WJ, Schlumpf M, Valk T, Bloom FE. Effect of experimental cerebral infarction in rat brain on catecholamines and behavior. Nature 1975 255 : 332 334.
30. Robinson RG. Differential behavior and biochemical effects of right and left hemispheric infarction in the rat. Science 1979 205 : 707 710.
31. DeBow S, Colbourne F. Brain temperature measurement and regulation in awake and freely moving rodents. Methods 2003 30 : 167 171.
32. Ginsberg MD, Sternau LL, Globus MY, Dietrich WD, Busto R. Therapeutic modulation of brain temperature: Relevance to ischemic brain injury. Cerebrovasc. Brain Metab. Rev. 1992 4 : 189 125.
33. Barber PA, Hoyte L, Colbourne F, Buchan AM. Temperature-regulated model of focal ischemia in the mouse: Study with histopathological and behavioral outcomes. Stroke 2004 35 : 1720 1725.
34. Wang Y, Zhang ZG, Rhodes K et al. Post-ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia. Br. J. Pharmacol. 2007 151 : 1377 1384.
35. Hurn PD, Brass LM. Estrogen and stroke: A balanced analysis. Stroke 2003 265 : 1883 1885.
36. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD. Gender-linked brain injury in experimental stroke. Stroke 1998 29 : 159 165.
37. McCullough LD, Hurn PD. Estrogen and ischemic neuroprotection: An integrated view. Trends Endocrinol. Metab. 2003 14 : 228 235.
38. DeBow SB, Clark DL, MacLellan CL, Colbourne F. Incomplete assessment of experimental cytoprotectants in rodent ischemia studies. Can. J. Neurol. Sci. 2003 30 : 368 374.