Increased risk of chronic wasting disease in Rocky Mountain elk associated with decreased magnesium and increased manganese in brain tissue

Canadian Journal of Veterinary Research

Volumn 74, Issue 1, 2010, Pages 50-53

  White, Stephen N ^a,b,f   O'Rourke, Katherine I ^a,b   Gidlewski, Thomas ^c   VerCauteren, Kurt C ^c   Mousel, Michelle R ^d   Phillips, Gregory E ^c   Spraker, Terry R ^e  

^a U S DEPARTMENT OF AGRICULTURE   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c NATIONAL WILDLIFE RESEARCH CENTER   (United States)

^d USDA ARS US Sheep Experiment Station   (United States)

^e Department of Environmental and Radiological Health Sciences   (United States)

^f Animal Disease Research Unit   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; LEUCINE; MAGNESIUM; MANGANESE; MINERAL; MOLYBDENUM; SELENIUM; ZINC;

ANIMAL EXPERIMENT; ARTICLE; BRAIN LEVEL; BRAIN TISSUE; CHRONIC WASTING DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; GENOTYPE; NONHUMAN; PRION; RED DEER;

ANIMALS; BIOLOGICAL MARKERS; BRAIN; COPPER; DEER; GENOTYPE; LEUCINE; MAGNESIUM; MANGANESE; METHIONINE; MOLYBDENUM; PRIONS; RISK FACTORS; SELENIUM; WASTING DISEASE, CHRONIC;

BOS; OVIS ARIES;

EID: 75649123376     PISSN: 08309000     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Williams ES. Chronic wasting disease. Vet Path 2005;42:530-549.
2. Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science 1982;216:136-144.
3. Miller MW, Williams ES, McCarty CW, et al. Epizootiology of chronic wasting disease in free-ranging cervids in Colorado and Wyoming. J Wildl Dis 2000;36:676-690.
4. Argue CK, Ribble C, Lees VW, McLane J, Balachandran A. Epidemiology of an outbreak of chronic wasting disease on elk farms in Saskatchewan. Can Vet J 2008;48:1241-1248.
5. O'Rourke KI, Besser TE, Miller MW, et al. PrP genotypes of captive and free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease. J Gen Virol 1999;80:2765-2769.
6. Perucchini M, Griffin K, Miller MW, Goldmann W. PrP genotypes of free-ranging wapiti (Cervus elaphus nelsoni) with chronic wasting disease. J Gen Virol 2008;89:1324-1328.
7. Hesketh S, Sassoon J, Knight R, Hopkins J, Brown DR. Elevated manganese levels in blood and central nervous system occur before onset of clinical signs in scrapie and bovine spongiform encephalopathy. J Anim Sci 2007;85:1596-1609.
8. Thackray AM, Knight R, Haswell SJ, Bujdoso R, Brown DR. Metal imbalance and compromised antioxidant function are early changes in prion disease. Biochem J 2002;362:253-258.
9. Brazier MW, Davies P, Player E, Marken F, Viles JH, Brown DR. Manganese binding to the prion protein. J Biol Chem 2008;283:12831-12839.
10. Hesketh S, Sassoon J, Knight R, Brown DR. Elevated manganese levels in blood and CNS in human prion disease. Mol Cell Neurosci 2008;37:590-598.
11. Choi CC, Kanthasamy A, Anantharam V, Kanthasamy AG. Interaction of metals with prion protein: Possible role of divalent cations in the pathogenesis of prion diseases. Neurotoxicology 2006;27:777-787.
12. Spraker TR, Balachandran A, Zhuang D, O'Rourke KI. Variable patterns of PrP-CWD distribution in obex and cranial lymphoid tissues of Rocky Mountain elk with nonclinical chronic wasting disease. Vet Rec 2004;155:295-302.
13. Helrich HE. Official methods of analysis of the Association of Official Analytical Chemists. Gaithersburg, Maryland: AOAC, 1990:Method 974,27.
14. Stahr HM. Analytical Methods in Toxicology. New York, New York: John Wiley & Sons, 1991.
15. Poole CF, Evans NJ, Wibberly DG. Determination of selenium in biological samples by gas-liquid chromatography with electroncapture detection. J Chromatogr 1977;136:73-83.
16. Tracy M, Melton L, Holstege D. Molybdenum quantitation by GFZAA. In: CVDLS Toxicology Laboratory Standard Methods. Davis, California: University of California, 1996.
17. Vink R, Cernak I. Regulation of intracellular free magnesium in central nervous system injury. Front Biosci 2000;5:D656-D665.
18. Goff JP. Macromineral disorders of the transition cow. Vet Clinic NA - Food Animal Practice 2004;20:471-494.
19. Johnson HE, Bleich VC, Krausman PR. Mineral deficiencies in tule elk, Owens Valley, California. J Wildl Dis 2007;43:61-74.
20. Wong BS, Brown DR, Pan T, et al. Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities. J Neurochem 2001;79:689-698.