Nandrolone excretion in sedentary vs physically trained young women

Scandinavian Journal of Medicine and Science in Sports

Volumn 20, Issue 1, 2010, Pages 90-99

  Enea, C ^a   Boisseau, N ^a   Bayle, M L ^b   Flament, M M ^b   Grenier Loustalot, M F ^b   Denjean, A ^c   Diaz, V ^a,d   Dugue B ^a  

^a UNIVERSITÉ DE POITIERS   (France)

^b CNRS   (France)

^c HÔPITAL ROBERT DEBRÉ   (France)

^d POITIERS UNIVERSITY HOSPITAL   (France)

Author keywords

Anabolic steroids; Athletes; Biological factors; Doping; Exercise; Gas chromatography mass spectrometry; Women

Indexed keywords

ANDROSTERONE; CREATININE; ETIOCHOLANOLONE; NANDROLONE; ORAL CONTRACEPTIVE AGENT;

ADOLESCENT; ADULT; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPING; EXERCISE; EXERCISE TEST; FEMALE; FOLLICULAR PHASE; HUMAN; LUTEAL PHASE; METABOLISM; OXYGEN CONSUMPTION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; URINE;

ADOLESCENT; ADULT; ANDROSTERONE; CONTRACEPTIVES, ORAL; CREATININE; DOPING IN SPORTS; ETIOCHOLANOLONE; EXERCISE; EXERCISE TEST; FEMALE; FOLLICULAR PHASE; HUMANS; LUTEAL PHASE; NANDROLONE; OXYGEN CONSUMPTION; YOUNG ADULT;

EID: 75649110391     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/j.1600-0838.2008.00877.x     Document Type: Article

References (28)

1. Abbott A. What price the Olympian ideal? Nature 2000 : 407 : 124 127.
2. Alström T, Gräsbeck R, Hjelm M, Skandsen S. Recommendations concerning the collection of reference values in clinical chemistry and activity report by the committee on reference values of the Scandinavian Society for Clinical Chemistry and Clinical Physiology. Scand J Clin Lab Invest 1975 : 144 (Suppl.) : 1 44.
3. Burtis C, Ashwood E., eds. Tietz textbook of clinical chemistry, 3rd edn. Philadelphia : WB Saunders, 1998.
4. Consitt L, Copeland J, Tremblay M. Hormone responses to resistance versus endurance exercise in premenopausal females. Can J Appl Physiol 2001 : 26 : 574 587.
5. de Boer D, de Jong E, Maes R, van Rossum J. The problems of oral contraceptives in dope control of anabolic steroids. Biomed Environ Mass Spectrom 1988 : 17 : 127 128.
6. Dehennin L, Jondet M, Scholler R. Androgen and 19-norsteroid profiles in human preovulatory follicles from stimulated cycles: an isotope dilution-mass spectrometric study. J Steroid Biochem 1987 : 26 : 399 405.
7. ElBeltagy K, Honda K, Ozaki K, Misugi T, Tokuyama O, Kimura M, Kira Y, Ishiko O. In vitro effect of dehydroepiandrosterone sulfate on steroid receptors, aromatase, cyclooxygenase-2 expression, and steroid hormone production in preovulatory human granulosa cells. Fertil Steril 2007 : 88 : 1135 1142.
8. Enea C, Boisseau N, Diaz V, Dugué B. Biological factors and the determination of androgens in female subjects. Steroids 2008, 73 : (12) : 1203 1216.
9. Forest M, Lecoq A, Saez J. Kinetics of human chorionic gonadotropin-induced steroidogenic response of the human testis. II. Plasma 17-hydroxyprogesterone, 4-androstenedione, estrone, and 17ß-estradiol: evidence for the action of human chorionic gonadotropin on intermediate enzymes implicated in steroid biosynthesis. J Clin Endocrinol Metab 1979 : 49 : 284 291.
10. Gambelunghe C, Sommavilla M, Rossi R. Testing for nandrolone metabolites in urine samples of professional athletes and sedentary subjects by GC/MS/MS analysis. Biomed Chromatogr 2002 : 16 : 508 512.
11. Grosse J, Anielski P, Hemmersbach P, Lund H, Mueller RK, Rautenberg C, Thieme D. Formation of 19-norsteroids by in situ demethylation of endogenous steroids in stored urine samples. Steroids 2005 : 70 : 499 506.
12. Hemmersbach P, Hågensen Jetne A, Lund H. Determination of urinary norandrosterone excretion in females during one menstrual cycle by gas chromatography/mass spectrometry. Biomed Chromatogr 2006 : 20 : 710 717.
13. Jurkowski J, Jones N, Walker C, Younglai E, Sutton J. Ovarian hormonal responses to exercise. J Appl Physiol 1978 : 44 : 109 114.
14. Le Bizec B, Bryand F, Gaudin I, Monteau F, Poulain F, Andre F. Endogenous nandrolone metabolites in human urine: preliminary results to discriminate between endogenous and exogenous origin. Steroids 2002 : 67 : 105 110.
15. Le Bizec B, Monteau F, Gaudin I, Andre F. Evidence for the presence of endogenous 19-norandrosterone in human urine. J Chomatogr B Biomed Sci Appl 1999 : 723 : 157 172.
16. Mahoudeau J, Valcke J, Bricaire H. Dissociated responses of plasma testosterone and estradiol to human chorionic gonadotropin in adult men. J Clin Endocrinol Metab 1975 : 41 : 13 20.
17. 2max in different phases of the menstrual cycle. Int J Sports Med 1990 : 11 : 198 203.
18. Mesaki N, Sasaki J, Shoji M, Iwasaki H, Asano K, Eda M. Hormonal changes during continuous exercise in athletic women. Nippon Sanka Fujinka Gakkai Zasshi 1987 : 39 : 63 69.
19. Reznik Y, Dehennin L, Coffin C, Mahoudeau J, Leymarie P. Urinary nandrolone metabolites of endogenous origin in man: a confirmation by output regulation under human chorionic gonadotropin stimulation. J Clin Endocrinol Metab 2001 : 86 : 146 150.
20. Reznik Y, Herrou M, Dehennin L, Lemaire M, Leymarie P. Rising plasma levels of 19-nortestosterone throughout pregnancy: determination by radioimmunoassay and validation by gas chromatography-mass spectrometry. J Clin Endocrinol Metab 1987 : 64 : 1086 1088.
21. Robinson N, Taroni F, Saugy M, Ayotte C, Mangin P, Dvorak J. Detection of nandrolone metabolites in urine after a football game in professional and amateur players: a Bayesian comparison. Forensic Sci Int 2001 : 122 : 130 135.
22. Schmitt N, Flament M, Goubault C, Legros P, Grenier-Loustalot M, Denjean A. Nandrolone excretion is not increased by exhaustive exercise in trained athletes. Med Sci Sports Exerc 2002 : 34 : 1436 1439.
23. The World Anti-Doping Agency (WADA). Minimum required performance limits for detection of prohibited substances. WADA technical document - TD2004MRPL. Available at
24. The World Anti-Doping Agency (WADA). Reporting and evaluation guidance for testosterone, epitestosterone, T/E ratio and other endogenous steroids. WADA technical document - TD2004EAAS. Available at
25. The World Anti-Doping Agency (WADA). Laboratory statistics. Available at
26. Thiblin I, Petersson A. Pharmacoepidemiology of anabolic androgenic steroids. Fundam Clin Pharmacol 2005 : 19 : 27 44.
27. Vandewalle H, Pérès G, Heller J, Monod H. All out anaerobic capacity tests on cycle ergometers. A comparative study on men and women. Eur J Appl Physiol Occup Physiol 1985 : 54 : 222 229.
28. Van Eenoo P, Delbeke F, de Jong F, De Backer P. Endogenous origin of norandrosterone in female urine: indirect evidence for the production of 19-norsteroids as by-products in the conversion from androgen to estrogen. J Steroid Biochem Mol Biol 2001 : 78 : 351 357.