Chemokine receptor expression and functional effects of chemokines on B cells: Implication in the pathogenesis of rheumatoid arthritis

Arthritis Research and Therapy

Volumn 11, Issue 5, 2009, Pages

  Nanki, Toshihiro ^a   Takada, Kazuki ^a   Komano, Yukiko ^a   Morio, Tomohiro ^a   Kanegane, Hirokazu ^b   Nakajima, Atsuo ^c,d   Lipsky, Peter E ^e   Miyasaka, Nobuyuki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

^d TOKYO METROPOLITAN POLICE HOSPITAL   (Japan)

^e NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; IMMUNOGLOBULIN M ANTIBODY; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR; B CELL ACTIVATING FACTOR RECEPTOR; CHEMOKINE RECEPTOR; ICOSLG PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; TNFRSF13B PROTEIN, HUMAN; TNFRSF13C PROTEIN, HUMAN; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LYMPHOCYTE PROLIFERATION; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS; SYNOVIUM; BIOSYNTHESIS; CELL PROLIFERATION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; NEUTROPHIL CHEMOTAXIS;

ANTIGENS, CD; ARTHRITIS, RHEUMATOID; B-CELL ACTIVATION FACTOR RECEPTOR; B-LYMPHOCYTES; CELL PROLIFERATION; CHEMOTAXIS, LEUKOCYTE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; LYMPHOCYTE ACTIVATION; RECEPTORS, CHEMOKINE; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 75649100559     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2823     Document Type: Article

References (38)

1. Edwards JC, Cambridge G. Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology (Oxford) 2001, 40:205-211. 10.1093/rheumatology/40.2.205, 11257159.
2. Cohen SB, Emery P, Greenwald MW, Dougados M, Furie RA, Genovese MC, Keystone EC, Loveless JE, Burmester GR, Cravets MW, Hessey EW, Shaw T, Totoritis MC. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 2006, 54:2793-2806. 10.1002/art.22025, 16947627.
3. Lundy SK, Sarkar S, Tesmer LA, Fox DA. Cells of the synovium in rheumatoid arthritis. T lymphocytes. Arthritis Res Ther 2007, 9:202. 10.1186/ar2107, 1860060, 17306038.
4. Kinne RW, Stuhlmuller B, Burmester GR. Cells of the synovium in rheumatoid arthritis. Macrophages. Arthritis Res Ther 2007, 9:224. 10.1186/ar2333, 2246244, 18177511.
5. Lutzky V, Hannawi S, Thomas R. Cells of the synovium in rheumatoid arthritis. Dendritic cells. Arthritis Res Ther 2007, 9:219. 10.1186/ar2200, 2206384, 17850683.
6. Mauri C, Ehrenstein MR. Cells of the synovium in rheumatoid arthritis. B cells. Arthritis Res Ther 2007, 9:205. 10.1186/ar2125, 1906792, 17349064.
7. Randen I, Brown D, Thompson KM, Hughes-Jones N, Pascual V, Victor K, Capra JD, Forre O, Natvig JB. Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue. J Immunol 1992, 148:3296-3301.
8. Roosnek E, Lanzavecchia A. Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells. J Exp Med 1991, 173:487-489. 10.1084/jem.173.2.487, 2118796, 1703209.
9. van Zeben D, Hazes JM, Zwinderman AH, Cats A, Voort EA, Breedveld FC. Clinical significance of rheumatoid factors in early rheumatoid arthritis: results of a follow up study. Ann Rheum Dis 1992, 51:1029-1035. 10.1136/ard.51.9.1029, 1004831, 1417131.
10. Duddy ME, Alter A, Bar-Or A. Distinct profiles of human B cell effector cytokines: a role in immune regulation?. J Immunol 2004, 172:3422-3427.
11. Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000, 12:121-127. 10.1016/S1074-7613(00)80165-X, 10714678.
12. Yoshie O, Imai T, Nomiyama H. Chemokines in immunity. Adv Immunol 2001, 78:57-110. full_text, 11432208.
13. Jin T, Xu X, Hereld D. Chemotaxis, chemokine receptors and human disease. Cytokine 2008, 44:1-8. 10.1016/j.cyto.2008.06.017, 2613022, 18722135.
14. Koch AE. Chemokines and their receptors in rheumatoid arthritis: future targets?. Arthritis Rheum 2005, 52:710-721. 10.1002/art.20932, 15751074.
15. Tak PP. Chemokine inhibition in inflammatory arthritis. Best Pract Res Clin Rheumatol 2006, 20:929-939. 10.1016/j.berh.2006.06.001, 16980215.
16. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988, 31:315-324. 10.1002/art.1780310302, 3358796.
17. Brandes M, Legler DF, Spoerri B, Schaerli P, Moser B. Activation-dependent modulation of B lymphocyte migration to chemokines. Int Immunol 2000, 12:1285-1292. 10.1093/intimm/12.9.1285, 10967023.
18. Armengol MP, Cardoso-Schmidt CB, Fernandez M, Ferrer X, Pujol-Borrell R, Juan M. Chemokines determine local lymphoneogenesis and a reduction of circulating CXCR4+ T and CCR7 B and T lymphocytes in thyroid autoimmune diseases. J Immunol 2003, 170:6320-6328.
19. Jones D, Benjamin RJ, Shahsafaei A, Dorfman DM. The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia. Blood 2000, 95:627-632.
20. Durig J, Schmucker U, Duhrsen U. Differential expression of chemokine receptors in B cell malignancies. Leukemia 2001, 15:752-756. 10.1038/sj.leu.2402107, 11368435.
21. Souto-Carneiro MM, Mahadevan V, Takada K, Fritsch-Stork R, Nanki T, Brown M, Fleisher TA, Wilson M, Goldbach-Mansky R, Lipsky PE. Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor. Arthritis Res Ther 2009, 11:R84. 10.1186/ar2718, 2714135, 19500335.
22. Hosaka S, Akahoshi T, Wada C, Kondo H. Expression of the chemokine superfamily in rheumatoid arthritis. Clin Exp Immunol 1994, 97:451-457. 1534851, 7521808.
23. Robinson E, Keystone EC, Schall TJ, Gillett N, Fish EN. Chemokine expression in rheumatoid arthritis (RA): evidence of RANTES and macrophage inflammatory protein (MIP)-1β production by synovial T cells. Clin Exp Immunol 1995, 101:398-407. 1553247, 7545093.
24. Ruth JH, Shahrara S, Park CC, Morel JC, Kumar P, Qin S, Koch AE. Role of macrophage inflammatory protein-3α and its ligand CCR6 in rheumatoid arthritis. Lab Invest 2003, 83:579-588.
25. Page G, Lebecque S, Miossec P. Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium. J Immunol 2002, 168:5333-5341.
26. Ueno A, Yamamura M, Iwahashi M, Okamoto A, Aita T, Ogawa N, Makino H. The production of CXCR3-agonistic chemokines by synovial fibroblasts from patients with rheumatoid arthritis. Rheumatol Int 2005, 25:361-367. 10.1007/s00296-004-0449-x, 15004722.
27. Buckley CD, Amft N, Bradfield PF, Pilling D, Ross E, Arenzana-Seisdedos F, Amara A, Curnow SJ, Lord JM, Scheel-Toellner D, Salmon M. Persistent induction of the chemokine receptor CXCR4 by TGFβ1 on synovial T cells contributes to their accumulation within the rheumatoid synovium. J Immunol 2000, 165:3423-3429.
28. Nanki T, Hayashida K, El-Gabalawy HS, Suson S, Shi K, Girschick HJ, Yavuz S, Lipsky PE. Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4 T cell accumulation in rheumatoid arthritis synovium. J Immunol 2000, 165:6590-6598.
29. Shi K, Hayashida K, Kaneko M, Hashimoto J, Tomita T, Lipsky PE, Yoshikawa H, Ochi T. Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients. J Immunol 2001, 166:650-655.
30. Kim HJ, Berek C. B cells in rheumatoid arthritis. Arthritis Res 2000, 2:126-131. 10.1186/ar77, 129995, 11094422.
31. Lee SK, Bridges SL, Koopman WJ, Schroeder HW. The immunoglobulin kappa light chain repertoire expressed in the synovium of a patient with rheumatoid arthritis. Arthritis Rheum 1992, 35:905-913. 10.1002/art.1780350809, 1642656.
32. Schroder AE, Greiner A, Seyfert C, Berek C. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci USA 1996, 93:221-225. 10.1073/pnas.93.1.221, 40210, 8552609.
33. Lipsky PE, Heijde DM, St Clair EW, Furst DE, Breedveld FC, Kalden JR, Smolen JS, Weisman M, Emery P, Feldmann M, Harriman GR, Maini RN. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med 2000, 343:1594-1602. 10.1056/NEJM200011303432202, 11096166.
34. Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, Kroczek RA. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 1999, 397:263-266. 10.1038/16717, 9930702.
35. Nanki T, Shimaoka T, Hayashida K, Taniguchi K, Yonehara S, Miyasaka N. Pathogenic role of the CXCL16-CXCR6 pathway in rheumatoid arthritis. Arthritis Rheum 2005, 52:3004-3014. 10.1002/art.21301, 16200580.
36. Nanki T, Lipsky PE. Cutting edge: stromal cell-derived factor-1 is a costimulator for CD4+ T cell activation. J Immunol 2000, 164:5010-5014.
37. Nanki T, Lipsky PE. Stimulation of T Cell Activation By CXCL12/Stromal Cell Derived Factor-1 Involves a G-Protein Mediated Signaling Pathway. Cell Immunol 2001, 214:145-154. 10.1006/cimm.2001.1890, 12088413.
38. Nanki T, Nagasaka K, Hayashida K, Saita Y, Miyasaka N. Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Immunol 2001, 167:5381-5385.