Body iron store as a predictor of oxidative DNA damage in healthy men and women

Cancer Science

Volumn 101, Issue 2, 2010, Pages 517-522

  Hori, Ai ^a,b   Mizoue, Tetsuya ^a   Kasai, Hiroshi ^c   Kawai, Kazuaki ^c   Matsushita, Yumi ^a   Nanri, Akiko ^a   Sato, Masao ^d   Ohta, Masanori ^b  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DNA; FERRITIN; HEMOGLOBIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; IRON STORAGE; MALE; OXIDATIVE STRESS; PREDICTOR VARIABLE; PRIORITY JOURNAL; SEX DIFFERENCE; SMOKING; URINE LEVEL;

ADULT; AGED; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; DEOXYGUANOSINE; DNA DAMAGE; FEMALE; FERRITINS; HUMANS; IRON; MALE; MENOPAUSE; MIDDLE AGED; OXIDATION-REDUCTION;

EID: 75649098218     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2009.01394.x     Document Type: Article

References (38)

1. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine 2007, 220-36. 4th edn, New York, Oxford University Press
2. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006, 160:1-40.
3. Toyokuni S. Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med 1996, 20:553-66.
4. Sawa T, Akaike T, Kida K, Fukushima Y, Takagi K, Maeda H. Lipid peroxyl radicals from oxidized oils and heme-iron: implication of a high-fat diet in colon carcinogenesis. Cancer Epidemiol Biomarkers Prev 1998, 7:1007-12.
5. Lee DH, Anderson KE, Folsom AR, Jacobs DR. Heme iron, zinc and upper digestive tract cancer: the Iowa Women's Health Study. Int J Cancer 2005, 117:643-7.
6. Zhou W, Park S, Liu G. Dietary iron, zinc, and calcium and the risk of lung cancer. Epidemiology 2005, 16:772-9.
7. Hann HW, Kim CY, London WT, Blumberg BS. Increased serum ferritin in chronic liver disease: a risk factor for primary hepatocellular carcinoma. Int J Cancer 1989, 43:376-9.
8. Knekt P, Reunanen A, Takkunen H, Aromaa A, Heliovaara M, Hakulinen T. Body iron stores and risk of cancer. Int J Cancer 1994, 56:379-82.
9. Selby JV, Friedman GD. Epidemiologic evidence of an association between body iron stores and risk of cancer. Int J Cancer 1988, 41:677-82.
10. Stevens RG, Graubard BI, Micozzi MS, Neriishi K, Blumberg BS. Moderate elevation of body iron level and increased risk of cancer occurrence and death. Int J Cancer 1994, 56:364-9.
11. Zacharski LR, Chow BK, Howes PS. Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial. J Natl Cancer Inst 2008, 100:996-1002.
12. Cross AJ, Gunter MJ, Wood RJ. Iron and colorectal cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study. Int J Cancer 2006, 118:3147-52.
13. Kato I, Dnistrian AM, Schwartz M. Iron intake, body iron stores and colorectal cancer risk in women: a nested case-control study. Int J Cancer 1999, 80:693-8.
14. Zacharski LR, Chow BK, Howes PS. Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial. JAMA 2007, 297:603-10.
15. Loft S, Svoboda P, Kasai H. Prospective study of 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion and the risk of lung cancer. Carcinogenesis 2006, 27:1245-50.
16. Cooke MS, Osborne JE, Singh R. Evidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients. Free Radic Biol Med 2007, 43:1328-34.
17. Thanan R, Murata M, Pinlaor S. Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis. Cancer Epidemiol Biomarkers Prev 2008, 17:518-24.
18. Nakano M, Kawanishi Y, Kamohara S. Oxidative DNA damage (8-hydroxydeoxyguanosine) and body iron status: a study on 2507 healthy people. Free Radic Biol Med 2003, 35:826-32.
19. Kasai H, Iwamoto-Tanaka N, Miyamoto T. Life style and urinary 8-hydroxydeoxyguanosine, a marker of oxidative dna damage: effects of exercise, working conditions, meat intake, body mass index, and smoking. Jpn J Cancer Res 2001, 92:9-15.
20. Mizoue T, Tokunaga S, Kasai H, Kawai K, Sato M, Kubo T. Body mass index and oxidative DNA damage: a longitudinal study. Cancer Sci 2007, 98:1254-8.
21. Tuomainen TP, Loft S, Nyyssonen K, Punnonen K, Salonen JT, Poulsen HE. Body iron is a contributor to oxidative damage of DNA. Free Radic Res 2007, 41:324-8.
22. Kohgo Y, Ikuta K, Ohtake T, Torimoto Y, Kato J. Body iron metabolism and pathophysiology of iron overload. Int J Hematol 2008, 88:7-15.
23. Murakami K, Mizoue T, Sasaki S. Dietary intake of folate, other B vitamins, and omega-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. Nutrition 2008, 24:140-7.
24. Kasai H, Svoboda P, Yamasaki S, Kawai K. Simultaneous determination of 8-hydroxydeoyguanosine, a marker of oxidative stress, and creatinine, a standardization compound, in urine. Ind Health 2005, 43:333-6.
25. Sasaki S, Tanaka H. Development and evaluation of dietary assessment methods using biomarkers and diet history questionnaires for individuals. (Japanese). Research for Evaluation Methods of Nutrition and Dietary Lifestyle Programs Held on Health Japan 21 2004, 10-44. In, ed, Summary report, Tokyo, Ministry of Health, Welfare, and Labour
26. Whitfield JB, Treloar S, Zhu G, Powell LW, Martin NG. Relative importance of female-specific and non-female-specific effects on variation in iron stores between women. Br J Haematol 2003, 120:860-6.
27. Amagai Y, Ishikawa S, Gotoh T, Kayaba K, Nakamura Y, Kajii E. Age at menopause and mortality in Japan: the Jichi Medical School Cohort Study. J Epidemiol 2006, 16:161-6.
28. Loft S, Vistisen K, Ewertz M, Tjonneland A, Overvad K, Poulsen HE. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis 1992, 13:2241-7.
29. Pilger A, Rudiger HW. 8-Hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures. Int Arch Occup Environ Health 2006, 80:1-15.
30. Cook JD, Lipschitz DA, Miles LE, Finch CA. Serum ferritin as a measure of iron stores in normal subjects. Am J Clin Nutr 1974, 27:681-7.
31. Torti FM, Torti SV. Regulation of ferritin genes and protein. Blood 2002, 99:3505-16.
32. Reif DW. Ferritin as a source of iron for oxidative damage. Free Radic Biol Med 1992, 12:417-27.
33. Carbonell T, Rama R. Iron, oxidative stress and early neurological deterioration in ischemic stroke. Curr Med Chem 2007, 14:857-74.
34. Van Asperen IA, Feskens EJ, Bowles CH, Kromhout D. Body iron stores and mortality due to cancer and ischaemic heart disease: a 17-year follow-up study of elderly men and women. Int J Epidemiol 1995, 24:665-70.
35. Hercberg S, Estaquio C, Czernichow S. Iron status and risk of cancers in the SU.VI.MAX cohort. J Nutr 2005, 135:2664-8.
36. Siah CW, Ombiga J, Adams LA, Trinder D, Olynyk JK. Normal iron metabolism and the pathophysiology of iron overload disorders. Clin Biochem Rev 2006, 27:5-16.
37. Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood 2003, 101:3359-64.
38. Lee DH, Zacharski LR, Jacobs DR. Comparison of the serum ferritin and percentage of transferrin saturation as exposure markers of iron-driven oxidative stress-related disease outcomes. Am Heart J 2006, 151.