Cisplatin-induced expression of Gb3 enables verotoxin-1 treatment of cisplatin resistance in malignant pleural mesothelioma cells

British Journal of Cancer

Volumn 102, Issue 2, 2010, Pages 383-391

  Johansson, D ^a   Andersson, C ^a   Moharer, J ^a   Johansson, A ^a   Behnam Motlagh, P ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Acquired resistance; Apoptosis; Cisplatin; Gb3; Mesothelioma; Verotoxin 1

Indexed keywords

CISPLATIN; GLOBOTRIASOSYLCERAMIDE 3; GLYCOLIPID; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VEROTOXIN 1;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIPOGENESIS; NICK END LABELING; PLEURA MESOTHELIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CISPLATIN; DRUG RESISTANCE, NEOPLASM; HUMANS; MESOTHELIOMA; PLEURAL NEOPLASMS; SHIGA TOXIN 1;

EID: 75549090958     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605467     Document Type: Article

References (39)

1. Andrews PA, Howell SB (1990) Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance. Cancer Cells 2: 35-43
2. Arab S, Rutka J, Lingwood C (1999) Verotoxin induces apoptosis and the complete, rapid, long-term elimination of human astrocytoma xenografts in nude mice. Oncol Res 11: 33-39
3. Brognard J, Clark AS, Ni Y, Dennis PA (2001) Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 61: 3986-3997
4. Brozovic A, Osmak M (2007) Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance. Cancer Lett 251: 1-16
5. Cvijic ME, Yang WL, Chin KV (1998) Cisplatin sensitivity in cAMP-dependent protein kinase mutants of Saccharomyces cerevisiae. Antic-ancer Res 18: 3187-3192
6. De Rosa MF, Ackerley C, Wang B, Ito S, Clarke DM, Lingwood C (2008) Inhibition of multidrug resistance by adamantylgb3, a globotriaosylcer-amide analog. J Biol Chem 283: 4501-4511
7. Derijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, Davis RJ (1995) Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267: 682-685
8. Endo Y, Tsurugi K, Yutsudo T, Takeda Y, Ogasawara T, Igarashi K (1988) Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins. Eur J Biochem 171: 45-50
9. Gariepy J (2001) The use of Shiga-like toxin 1 in cancer therapy. Crit Rev Oncol Hematol 39: 99-106
10. Han J, Lee JD, Jiang Y, Li Z, Feng L, Ulevitch RJ (1996) Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem 271: 2886-2891
11. Ishitoya S, Kurazono H, Nishiyama H, Nakamura E, Kamoto T, Habuchi T, Terai A, Ogawa O, Yamamoto S (2004) Verotoxin induces rapid elimination of human renal tumor xenografts in SCID mice. J Urol 171: 1309-1313
12. Jacewicz M, Feldman HA, Donohue-Rolfe A, Balasubramanian KA, Keusch GT (1989) Pathogenesis of Shigella diarrhea. XIV. Analysis of Shiga toxin receptors on cloned HeLa cells. J Infect Dis 159: 881-889
13. Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ (2003) Cancer statistics, 2003. CA Cancer J Clin 53: 5-26
14. Johansson D, Johansson A, Behnam-Motlagh P (2008) alpha-Toxin of Staphylococcus aureus overcomes acquired cisplatin-resistance in malignant mesothelioma cells. Cancer Lett 265: 67-75
15. Johansson D, Johansson A, Grankvist K, Andersson U, Henriksson R, Bergstrom P, Brannstrom T, Behnam-Motlagh P (2006) Verotoxin-1 induction of apoptosis in Gb3-expressing human glioma cell lines. Cancer Biol Ther 5: 1211-1217
16. Kasibhatla S, Tseng B (2003) Why target apoptosis in cancer treatment? Mol Cancer Ther 2: 573-580
17. Kim BJ, Ryu SW, Song BJ (2006) JNK-and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem 281: 21256-21265
18. Kovbasnjuk O, Mourtazina R, Baibakov B, Wang T, Elowsky C, Choti MA, Kane A, Donowitz M (2005) The glycosphingolipid globotriaosylcer-amide in the metastatic transformation of colon cancer. Proc Natl Acad Sci USA 102: 19087-19092
19. Krishan A, Fitz CM, Andritsch I (1997) Drug retention, efflux, and resistance in tumor cells. Cytometry 29: 279-285
20. LaCasse EC, Bray MR, Patterson B, Lim WM, Perampalam S, Radvanyi LG, Keating A, Stewart AK, Buckstein R, Sandhu JS, Miller N, Banerjee D, Singh D, Belch AR, Pilarski LM, Gariepy J (1999) Shiga-like toxin-1 receptor on human breast cancer, lymphoma, and myeloma and absence from CD34(+) hematopoietic stem cells: implications for ex vivo tumor purging and autologous stem cell transplantation. Blood 94: 2901-2910
21. Leard LE, Broaddus VC (2004) Mesothelial cell proliferation and apoptosis. Respirology 9: 292-299
22. Lee SY, Cherla RP and Tesh VL (2007) Simultaneous induction of apoptotic and survival signaling pathways in macrophage-like THP-1 cells by Shiga toxin 1. Infect Immun 75: 1291-1302
23. Lingwood CA, Khine AA, Arab S (1998) Globotriaosyl ceramide (Gb3) expression in human tumour cells: intracellular trafficking defines a new retrograde transport pathway from the cell surface to the nucleus, which correlates with sensitivity to verotoxin. Acta Biochim Pol 45: 351-359
24. Lingwood CA, Law H, Richardson S, Petric M, Brunton JL, De Grandis S, Karmali M (1987) Glycolipid binding of purified and recombinant Escherichia coli produced verotoxin in vitro. J Biol Chem 262: 8834-8839
25. Liu LZ, Zhou XD, Qian G, Shi X, Fang J, Jiang BH (2007) AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. Cancer Res 67: 6325-6332
26. Marklund SL, Westman NG, Lundgren E, Roos G (1982) Copper-and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res 42: 1955-1961
27. O'Brien AD, Tesh VL, Donohue-Rolfe A, Jackson MP, Olsnes S, Sandvig K, Lindberg AA, Keusch GT (1992) Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis. Curr Top Microbiol Immunol 180: 65-94
28. Ohmichi M, Hayakawa J, Tasaka K, Kurachi H, Murata Y (2005) Mechanisms of platinum drug resistance. Trends Pharmacol Sci 26: 113-116
29. Olsnes S, Sandvig K (1988) How protein toxins enter and kill cells. Cancer Treat Res 37: 39-73
30. Parkin DM (2001) Global cancer statistics in the year 2000. Lancet Oncol 2: 533-543
31. Rose PE, Clark AJ (1989) Haematology of the haemolytic uraemic syndrome. Blood Rev 3: 136-140
32. Salhia B, Rutka JT, Lingwood C, Nutikka A, Van Furth WR (2002) The treatment of malignant meningioma with verotoxin. Neoplasia 4: 304-311
33. Sandvig K, Grimmer S, Lauvrak SU, Torgersen ML, Skretting G, van Deurs B, Iversen TG (2002) Pathways followed by ricin and Shiga toxin into cells. Histochem Cell Biol 117: 131-141
34. Saxena SK, O'Brien AD, Ackerman EJ (1989) Shiga toxin, Shiga-like toxin II variant, and ricin are all single-site RNA N-glycosidases of 28 S RNA when microinjected into Xenopus oocytes. J Biol Chem 264: 596-601
35. Siddik ZH (2003) Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22: 7265-7279
36. Vingert B, Adotevi O, Patin D, Jung S, Shrikant P, Freyburger L, Eppolito C, Sapoznikov A, Amessou M, Quintin-Colonna F, Fridman WH, Johannes L, Tartour E (2006) The Shiga toxin B-subunit targets antigen in vivo to dendritic cells and elicits anti-tumor immunity. Eur J Immunol 36: 1124-1135
37. Walchli S, Skanland SS, Gregers TF, Lauvrak SU, Torgersen ML, Ying M, Kuroda S, Maturana A, Sandvig K (2008) The mitogen-activated protein kinase p38 links Shiga toxin-dependent signaling and trafficking. Mol Biol Cell 19: 95-104
38. Zhou S-F (2008) Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition. Xenobiot 38: 802-832
39. Zwelling LA, Anderson T, Kohn KW (1979) DNA-protein and DNA interstrand cross-linking by cis-and trans-platinum(II) diammine-dichloride in L1210 mouse leukemia cells and relation to cytotoxicity. Cancer Res 39: 365-369