Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner

Cancer Chemotherapy and Pharmacology

Volumn 65, Issue 3, 2010, Pages 427-436

  Kurokawa, Tetsuji ^a,b   He, Guangan ^a   Siddik, Zahid H ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF FUKUI   (Japan)

Author keywords

Cisplatin; DRB; Drug transport; Emodin; HCtr1; Resistance

Indexed keywords

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; CARRIER PROTEIN; CISPLATIN; EMODIN; PROTEIN HCTRL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CATION TRANSPORT PROTEIN; NUCLEIC ACID SYNTHESIS INHIBITOR; PROTEIN KINASE INHIBITOR; SLC31A1 PROTEIN, HUMAN;

ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DRUG UPTAKE; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; CELL PROLIFERATION; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENETICS; IC 50; INTRACELLULAR SPACE; METABOLISM; OVARY TUMOR; PATHOLOGY; RNA INTERFERENCE; TIME; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CATION TRANSPORT PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CISPLATIN; DICHLORORIBOFURANOSYLBENZIMIDAZOLE; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EMODIN; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; INTRACELLULAR SPACE; NUCLEIC ACID SYNTHESIS INHIBITORS; OVARIAN NEOPLASMS; PROTEIN KINASE INHIBITORS; RNA INTERFERENCE; SPECTROPHOTOMETRY, ATOMIC; TIME FACTORS;

EID: 75549089135     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-1045-2     Document Type: Article

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