Substance-tailored testing strategies in toxicology: An in silico methodology based on QSAR modeling of toxicological thresholds and Monte Carlo simulations of toxicological testing

Regulatory Toxicology and Pharmacology

Volumn 56, Issue 1, 2010, Pages 82-92

  Péry, Alexandre R R ^a   Desmots, S ^a   Mombelli, E ^a  

^a INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES INERIS   (France)

Author keywords

Decision analysis; Integrated testing strategies; QSAR; Teratogenicity; Test batteries; Uncertainty

Indexed keywords

INDOMETACIN; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

ARTICLE; COMPUTER MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; DECISION SUPPORT SYSTEM; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; GENETIC ALGORITHM; MONTE CARLO METHOD; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TERATOGENICITY; TOXICITY TESTING;

ANIMALS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HAZARDOUS SUBSTANCES; MODELS, CHEMICAL; MONTE CARLO METHOD; PREGNANCY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; THRESHOLD LIMIT VALUES; TOXICITY TESTS; TOXICOLOGY;

ANIMALIA;

EID: 75549088521     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.09.009     Document Type: Article

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