Synthesis, biological assays and QSAR studies of N-(9-benzyl-2-phenyl-8-azapurin-6-yl)-amides as ligands for A1 adenosine receptors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 5, 2009, Pages 1817-1830

  Giorgi, Irene ^a   Leonardi, Michele ^a   Pietra, Daniele ^b   Biagi, Giuliana ^a   Borghini, Alice ^a   Massarelli, Ilaria ^a   Ciampi, Osele ^a   Bianucci, Anna Maria ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Ricerche in Farmacologia Clinica e Terapia Sperimentale   (Italy)

Author keywords

2 Phenyl 9 benzyl 8 azapurines; Adenosine receptor ligands; Classification; QSAR, regression

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A3 RECEPTOR; ALKYL GROUP; LIGAND; N (9 BENZYL 2 PHENYL 8 AZAPURIN 6 YL) AMIDE DERIVATIVE; PHENYL GROUP; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOASSAY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; LIGAND BINDING; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; NONHUMAN; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STATISTICAL ANALYSIS; SUBSTITUTION REACTION;

ANIMALS; KINETICS; LIGANDS; PURINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A3;

EID: 61549106255     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.060     Document Type: Article

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