Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes

Biophysical Chemistry

Volumn 147, Issue 1-2, 2010, Pages 59-65

  Yamamoto, Takashi ^a   Sugawara, Mitsuru ^a   Kikukawa, Takashi ^a   Miyauchi, Seiji ^b   Yamaguchi, Masahiro ^a   Tero, Atsushi ^c   Takagi, Seiji ^a   Nakagaki Toshiyuki, T ^a,c  

^a HOKKAIDO UNIVERSITY   (Japan)

^b MATSUYAMA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Diffusion; Mathematical model; Nucleoside transporter

Indexed keywords

CONCENTRATIVE NUCLEOSIDE TRANSPORTER 3; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; NITROBENZYLTHIOINOSINE; NUCLEOSIDE TRANSPORTER; RECOMBINANT PROTEIN; RIBAVIRIN; SODIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL INTERACTION; CELL MEMBRANE TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DRUG UPTAKE; ELECTROPHYSIOLOGY; EXTRACELLULAR SPACE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NONHUMAN; OOCYTE; PREDICTION; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS MODEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SODIUM CURRENT; TRANSPORT KINETICS; XENOPUS LAEVIS;

ANIMALS; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; KINETICS; MODELS, BIOLOGICAL; NUCLEOSIDE TRANSPORT PROTEINS; OOCYTES; RIBAVIRIN; SODIUM CHLORIDE; THIOINOSINE; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 75549086323     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpc.2009.12.012     Document Type: Article

References (20)

1. Sidwell R.W., Huffman J.H., Khare G.P., Allen L.B., Witkowski J.T., et al. Broad-spectrum antiviral activity of Virazole: 1-beta-d-ribofuranosyl-1, 2, 4-triazole-3-carboxamide. Science 1972, 177:705-706.
2. Feld J.J., Hoofnagle J.H. Mechanism of action of interferon and ribavirin in treatment of hepatitis C. Nature 2005, 436:967-972.
3. Ohisalo J.J. Regulatory functions of adenosine. Med. Biol. 1987, 65:181-191.
4. Boison D. Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies. Neuroscientist 2005, 11:25-36.
5. Kong W., Engel K., Wang J. Mammalian nucleoside transporters. Curr. Drug Metab. 2005, 5:63-84.
6. Podgorska M., Kocbuch K., Pawelczyk T. Recent advances in studies on biochemical and structural properties of equilibrative and concentrative nucleoside transporters. Acta. Biochim. Pol. 2005, 52:749-758.
7. Ritzel M.W., Yao S.Y., Huang M.Y., Elliott J.F., Cass C.E., et al. Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). Am. J. Physiol. 1997, 272:707-714.
8. Wang J., Su S.F., Dresser M.J., Schaner M.E., Washington C.B., et al. Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. Am. J. Physiol. 1997, 273:1058-1065.
9. Ritzel M.W., Yao S.Y., Ng A.M., Mackey J.R., Cass C.E., et al. Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Mol. Membr. Biol. 1998, 15:203-211.
10. Ritzel M.W.L., Ng A.M.L., Yao S.Y.M., Graham K., Loewen S.K., Smith K.M., Ritzel R.G., Mowles D.A., Carpenter P., Chen X.-Z., Karpinski E., Hyde R.J., Baldwin S.A., Cass C.E., Young J.D. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J. Biol. Chem. 2001, 276:2914-2927.
11. Griffiths M., Beaumont N., Yao S.Y., Sundaram M., Boumah C.E., et al. Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. Nat. Med. 1997, 3:89-93.
12. Crawford C.R., Patel D.H., Naeve C., Belt J.A. Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. J. Biol. Chem. 1998, 273:5288-5293.
13. Deussen A., Stappert M., Schafer S., Kelm M. Quantification of extracellular and intracellular adenosine production - understanding the transmembranous concentration gradient. Circulation 1999, 99:2041-2047.
14. Podgorska M., Kocbuch K., Pawelczyk T. Recent advances in studies on biochemical and structural properties of equilibrative and concentrative nucleoside transporters. Acta Biochim. Pol. 2005, 52:749-758.
15. Centelles J., Cascante M., Canela E.I., Franco R. A model for adenosine transport and metabolism. Biochem. J. 1992, 287:461-472.
16. Yamamoto T., Kuniki K., Takekuma Y., Hirano T., Iseki K., et al. Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters. Eur. J. Pharmacol. 2007, 557:1-8.
17. Fei Y.-J., Sugawara M., Liu J.-C., Li H.W., Ganapathy V., et al. cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1. Biochim. Biophys. Acta 2000, 1492:145-154.
18. - pump activity. Biophys. J. 2007, 92:2559-2569.
19. Keener J.P., Sneyd J. Mathematical Biology 1999, Springer-Verlag, New York.
20. Shey Jonathan V., Ackerman Joseph J.H., Neil Jeffrey J. Apparent diffusion of water, ion, and small analogues in the Xenopus Oocyte is consistent with Brownian displacement. Magn. Reson. Med. 2002, 48:42-51.