Dietary fat, genetic predisposition, and obesity: Lessons from animal models

American Journal of Clinical Nutrition

Volumn 67, Issue 3 SUPPL., 1998, Pages

  West, David B ^a   York, Barbara ^b  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

Animal models; Dietary fat; Dogs; Environment; Genetic predisposition; Hamsters; Humans; Hyperphagia; Mice; Monkeys; Obesity; Pigs; Rats; Squirrels

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; CONFERENCE PAPER; DOG; DOSE RESPONSE; FAT INTAKE; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HAMSTER; MONKEY; NONHUMAN; OBESITY; SQUIRREL; SWINE;

ANIMALIA; CANIS FAMILIARIS; CRICETINAE; RODENTIA; SCIURIDAE; SUS SCROFA;

EID: 0031930804     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/67.3.505S     Document Type: Conference Paper

References (71)

1. Seidell JC. Dietary fat and obesity: an epidemiologic perspective. Am J Clin Nutr 1998;67:5468-508.
2. Horton TJ, Drougas H, Brachey A, Reed GW, Peters JC, Hill JO. Fat and carbohydrate overfeeding humans: different effects on energy storage. Am J Clin Nutr 1995;62:19-29.
3. Blundell JE, Cotton JR, Delargy H, et al. The fat paradox: fat-induced satiety signals versus high fat overconsumption. Int J Obes 1995;19:832-5.
4. Kemnitz JW. Obesity in Macaques: spontaneous and induced. Adv Vet Sci Comp Med 1984;28:81-114.
5. Ausman LM, Rasmussen KM, Gallinam DL. Spontaneous obesity in maturing squirrel monkeys fed semipurified diets. Am J Physiol 1981;241:R316-21.
6. Jen KL. Failure to induce weight gain with palatable diets in monkeys (Macaca mulatta). Primates 1987;28:61-9.
7. Lewis DS, Bertrand HA, McMahan CA, McGill HC, Carey KD, Masoro EJ. Influence of preweaning food intake on body composition of young adult baboons. Am J Physiol 1989;257:R1128-35.
8. Hand MS, Armstrong PJ, Allen TA. Obesity: occurrence, treatment and prevention. Vet Clin North Am 1989;19:447-74.
9. Edney AT, Smith PM. Study of obesity in dogs visiting veterinary practices in the United Kingdom. Vet Rec 1986;118:391-6.
10. Romsos DR, Belo PS, Bennink MR, Bergen WG, Leveille GA. Effects of dietary carbohydrate, fat and protein on growth, body composition and blood metabolite levels in the dog. J Nutr 1976;106:1452-64.
11. Romsos DR, Hornshuh MJ, Leveille GA. Influence of dietary fat and carbohydrate on food intake, body weight and body fat of adult dogs. Fed Proc 1978;157:278-81.
12. Rocchini AP, Moorehead CP, DeRemer S, Bondie D. Pathogenesis of weight-related changes in blood pressure in dogs. Hypertension 1989;13:922-8.
13. Pond WG, Mersmann HJ, Yen JT. Effect of obesity per se on plasma lipid and aortic responses to diet in swine. Fed Proc 1985;179:90-5.
14. Diersen-Schade DA, Richard MJ, Beitz DC, Jacobson NL. Effects of beef, soy and conventional diets on body composition and plasma lipids of young pigs fed restricted and liberal amounts of diet. J Nutr 1985;115:1016-24.
15. Allee GL, O'Hea EK, Leveille GA, Baker DH. Influence of dietary protein and fat on lipogenesis and enzymatic activity in pig adipose tissue. J Nutr 1971;101:869-78.
16. Frobish LT, Hays VW, Speer VC, Ewan RC. Effect of fat source and level on utilization of fat by young pigs. J Anim Sci 1970;30:197-202.
17. Borer KT. Absence of weight regulation in exercising hamsters. Physiol Behav 1974;12:589-97.
18. Wade GN. Obesity without overeating in golden hamsters. Physiol Behav 1982;29:701-7.
19. Hamilton JM, Wade GN. Lipectomy does not impair fattening induced by short photoperiods or high-fat diets in female Syrian hamsters. Physiol Behav 1988;43:85-92.
20. Faust IM, Mrosovsky N. Resistance to adipocyte hyperplasia in ground squirrels given high-fat diets. Am J Physiol 1987;253:R576-9.
21. Dark J, Ruby NR, Wade GN, Licht P, Zucker I. Accelerated reproductive development in juvenile male ground squirrels fed a high-fat diet. Am J Physiol 1992;262:R644-50.
22. Sclafani A. Dietary obesity. In: Stunkard AJ, Wadden TA (eds) 2nd ed. Obesity: theory and therapy. New York: Raven Press, Ltd, 1993:125-35.
23. Sclafani A. Diet-induced obesity in rodents. In: Oomura Y, Tarui S, Inoue S, et al, eds. Progress in obesity research. London: John Libbey and Co, 1991:441-4.
24. Mickelsen O, Takahashi S, Craig C. Experimental obesity I: production of obesity in rats by feeding high-fat diets. J Nutr 1955;57:541-54.
25. Fenton PF, Carr CJ. The nutrition of the mouse. XI. Response of four strains to diets differing in fat content. J Nutr 1951;45:225-33.
26. Lemmonier D. Effect of age, sex, and site on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet. J Clin Invest 1972;51:2907-15.
27. West DB, Boozer CN, Moody DL, Atkinson RL. Obesity induced by a high-fat diet in nine strains of inbred mice. Am J Physiol 1992;262:R1025-32.
28. Levin BE, Sullivan AC. Glucose-induced norepinephrine levels and obesity resistance. Am J Physiol 1987;253:R475-81.
29. Oscai LB, Brown MM, Miller WC. Effect of dietary fat on food intake growth and body composition in rats. Growth 1984;48:415-24.
30. Faust IM, Johnson PR, Stern JS, Hirsch J. Diet-induced adipocyte number increase in adult rats: a new model of obesity. Am J Physiol 1978;235:E279-86.
31. Schemmel R, Mickelsen O, Gill JL. Dietary obesity in rats: body weight and body fat accretion in seven strains of rat. J Nutr 1970;100:1041-8.
32. Sclafani A, Springer D. Dietary obesity in adult rats: similarities to hypothalamic and human obesity syndromes. Physiol Behav 1976;17:461-71.
33. Rothwell NJ, Stock MJ. The cafeteria diets as a tool for studies of thermogenesis. J Nutr 1988;118:925-8.
34. Prats E, Monfar M, Castella J, Iglesias R, Alemany M. Energy intake of rats fed a cafeteria diet. Physiol Behav 1989;45:263-72.
35. Kanarek RB, Orthen-Gambill N. Differential effects of sucrose, fructose and glucose on carbohydrate-induced obesity in rats. J Nutr 1982;112:1546-54.
36. Sclafani A. Carbohydrate-induced hyperphagia and obesity in the rat: effects of saccharide type, form and taste. Neurosci Biobehav Rev 1987;11:155-62.
37. Sclafani A. Carbohydrate taste, appetite, and obesity: an overview. Neurosci. Biobehav Rev 1987;11:131-53.
38. Ramirez I. Feeding a liquid diet increases energy intake, weight gain and body fat in rats. J Nutr 1987;117:2127-34.
39. Peckham SC, Entenman C, Carrol HW. The influence of a hypercaloric diet on gross body and adipose tissue composition in the rat. J Nutr 1962;77:187-97.
40. 4: Technomic Publishing Co, 1978:123-32.
41. West DB, Waguespack J, McCollister S. Dietary obesity in the mouse: interaction of strain with diet composition. Am J Physiol 1995;268:R658-65.
42. Boozer CN, Schoenbach G, Atkinson RL. Dietary fat and adiposity: a dose-response relationship in adult male rats fed isocalorically. Am J Physiol 1995;268:E546-50.
43. Edozien JC, Switzer BR. Influence of diet on growth in the rat. J Nutr 1978;108:282-90.
44. Ramirez I. Does dietary hyperphagia contradict the lipostatic theory? Neurosci Biobehav Rev 1990;14:117-23.
45. Oscai LB, Miller WC, Arnall DA. Effects of dietary sugar and of dietary fat on food intake and body fat content in rats. Growth 1987;51:64-73.
46. Cohn C, Joseph D. Effects on metabolism produced by the rate of ingestion of the diet. Am J Clin Nutr 1960;8:682-90.
47. Bultman SJ, Michaud EJ, Woychik RP. Molecular characterization of the mouse agouti locus. Cell 1992;71:1195-204.
48. Zhang Y, Proenca R, Maffei M, Barone M, Lepold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
49. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-7.
50. Naggert JK, Fricker LD, Varlamov O, et al. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nature Genet 1995;10:135-42.
51. Noben-Trauth K, Naggert JK, North MJA, Nishina PM. A candidate gene for the mouse mutation tubby. Nature 1996;380:534-8.
52. Kleyn PW, Fat W, Kovats SG, et al. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell 1996;85:281-90.
53. Alonso LG, Maren TH. Effect of food restriction on body composition of hereditary obese mice. Am J Physiol 1955;183:284-90.
54. Cleary MP, Vasselli JR, Greenwood MR. Development of obesity in Zucker (fafa) rat in absence of hyperphagia. Am J Physiol 1980;238:E284-92.
55. Vasselli JR, Fiene JA, Maggio CA. Relationship of adipocyte size to hyperphagia in developing male obese Zucker rats. Am J Physiol 1992;262:R33-8.
56. Lin PY, Romsos DR, Vander Tuig JG, Leveille GA. Maintenance energy requirements, energy retention and heat production of young obese (ob/ob) and lean mice fed a high-fat or a high-carbohydrate diet. J Nutr 1979;109:1143-53.
57. Crofford OB, Davis CK. Growth characteristics, glucose tolerance and insulin sensitivity of New Zealand Obese mice. Metabolism 1965;14:271-80.
58. Bray GA, York DA. Hypothalamic and genetic obesity in experimental animals: an autocrine and endocrine hypothesis. Physiol Rev 1979;59:719-809.
59. Gleason RE, Lauris V, Soeldner JS. Studies on experimental diabetes in the Wellesley hybrid mouse. Diabetologia 1967;3:175-8.
60. Herberg L, Doeppen W, Major E, Gries FA. Dietary induced hypertrophic-hyperplastic obesity in mice. J Lipid Res 1974;6:580-5.
61. Fisler JS, Warden CH, Pace MJ, Lusis AJ. BSB: a new mouse model of multigenic obesity. Obes Res 1993;1:271-80.
62. Warden CH, Fisler JS, Shoemaker SM, et al. Identification of four chromosomal loci determining obesity in a multifactorial mouse model. J Clin Invest 1995;95:1545-52.
63. West DB, Waguespack J, York B, Goudey-Lefevre J, Price GA. Genetics of dietary obesity in AKR/J × SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. Mamm Genome 1994;5:546-52.
64. West DB, Goudey-Lefevre J, York B, Truett GE. Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Invest 1994;94:1410-6.
65. West DB, York B. Genetic models of obesity in animals. Obes Res 1995;3(suppl 36:315S (abstr).
66. York B, Lei K, West DB. Sensitivity to dietary obesity linked to a locus on chromosome 15 in a CAST/Ei × C57BL/6J intercross. Mamm Genome 1996;7:677-81.
67. Warden CH, Fisler JS. Identification of genes underlying polygenic obesity in animal models. In: Bouchard C, ed. The genetics of obesity. Boca Raton, FL: CRC Press, 1994:181-97.
68. Neel JV. Diabetes mellitus: a thrifty genotype rendered detrimental by "progress"? Am J Hum Genet 1962;14:353-62.
69. Neel JV. Towards a better understanding of the genetic basis of diabetes mellitus. In: Creutzfeldt W, Kobberling J, Neel JV, eds. The genetics of diabetes mellitus. Berlin: Springer Verlag, 1976:240-4.
70. Bouchard D, Tremblay A, Despres J, et al. The response to long-term overfeeding in identical twins. N Engl J Med 1990;322:1477-82.
71. Garn SM, Leonard WR, Hawthorne VM. Three limitations of the body mass index. Am J Clin Nutr 1986;44:996-7.