In vitro and in vivo evaluations of PLGA microsphere vaccine formulations containing pDNA coexpressing Hepatitis B surface antigen and Interleukin-2

Journal of Microencapsulation

Volumn 27, Issue 1, 2010, Pages 48-56

  Eratalay, Aydan ^a   Coşkun Ari, F Filiz ^b   Öner, Filiz ^a   Özcenig, Erkan ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b SULEYMAN DEMIREL UNIVERSITY   (Turkey)

Author keywords

Hepatitis B surface antigen; IL 2; Microsphere; Plasmid DNA; PLGA; Vaccine

Indexed keywords

DNA VACCINE; HEPATITIS B SURFACE ANTIGEN; INTERLEUKIN 2; MICROSPHERE; PLASMID DNA; POLYGLACTIN; SOLVENT; WATER OIL CREAM; DNA; LACTIC ACID; MICROCAPSULE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; VACCINE;

ADSORPTION; ANIMAL EXPERIMENT; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA IMMUNIZATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SYNTHESIS; EMULSION; EVAPORATION; HEPATITIS B VIRUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROENCAPSULATION; MOUSE; NONHUMAN; PARTICLE SIZE; PHASE TRANSITION; TIBIALIS ANTERIOR MUSCLE; VIRUS ENVELOPE; VIRUS INFECTION; ZETA POTENTIAL; ADMINISTRATION AND DOSAGE; ANIMAL; ANTIBODY PRODUCTION; CHEMISTRY; GENE EXPRESSION; GENETICS; IMMUNIZATION; IMMUNOLOGY; MICROCAPSULE; PLASMID;

ANIMALS; ANTIBODY FORMATION; CAPSULES; DNA; GENE EXPRESSION; HEPATITIS B SURFACE ANTIGENS; IMMUNIZATION; INTERLEUKIN-2; LACTIC ACID; MALE; MICE; PLASMIDS; POLYGLYCOLIC ACID; VACCINES;

EID: 75449117667     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652040902937666     Document Type: Article

References (38)

1. Ando S, Putnam D, Pack DW, Langer R. 1998. PLGA microspheres containing plasmid DANN: Preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. J Pharm Sci 88:126-130.
2. Boyer JD, Ugen KE, Wang B, Agadjanyani MG, Gilbert L, Bagarazzi ML, et al.. 1997. Protection of chimpanzees from high-dose heterologous HIV-I challenge by DNA vaccination. Nature Med 3:526-532.
3. Choudary S, Ravikumar P, Ashok Kumar C, Suryanarayana VVS, Reddy GR. 2008. Enhanced immune response of DNA vaccine (VP1-pCDNA) adsorbed on cationic PLG for foot and mouth disease in guinea pig. Virus Genes 37:81-87.
4. Chow YH, Huang WL, Chi WK, Chu YD, Tao MH. 1997. Improvement of Hepatitis B virus DNA vaccines by plasmids coexpressing Hepatitis B surface antigen and interleukin-2. J Virol 71:169-179.
5. Coelho-Castelo AA, Santos Junior RR, Bonato VDL, Jamur MC, Oliver C, Silva CL. 2003. B-lymphocytes in bone marrow or lymph nodes can take up plasmid DNA after intramuscular delivery. Human Gene Ther 14:1279-1285.
6. Dastan T, Turan K. 2004. In vitro characterization and delivery of chitosan-DNA microparticles into mammalian cells. J Pharm Pharm Sci 7:205-214.
7. Davis HL, Michel ML, Whalen RG. 1993. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Human Molec Genet 2:1847-1851.
8. Denis-Mize KS, Dupuis M, MacKichan ML, Singh M, Doe B, O'Hagan D, et al.. 2000. Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells. Gene Therapy 7:2105-2112.
9. Dietrich G, Spreng S, Favre D, Viret JF, Guzman CA. 2003. Live attenuated bacteria as vectors to deliver plasmid DNA vaccines. Curr Opin Molec Ther 5:10-19.
10. Diez S, Tros de Ilarduya C. 2006. Versatility of biodegredabla poly(D;Llactic-co-glycolic acid) microspheres for plasmid DNA delivery. Eur J Pharm Biopharm 63:188-197.
11. Espuelay S, Irache JM, Gamazo C. 2005. Synthetic particulate antigen delivery systems for vaccination. Immunologia 24:208-223.
12. Fu K, Pack DW, Klibanow AM, Langer R. 2000. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm Res 17:100-106.
13. Garg S, Oran A, Wajchman J, Sasaki S, Maris CH, Kapp JA, et al.. 2003. Genetic tagging shows increased frequency and longevity of antigenpresenting, skin derived dendritic cells in vivo. Nature Immunol 4:907-912.
14. Gregoriadis G, Saffie R, Souza JB. 1997. Mediated DNA vaccination. FEBS Lett 402:107-110.
15. He XW, Wang F, Jiang L, Li J, Liu SK, Xiao ZY, et al.. 2005. Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg. J Gen Virol 86:601-610.
16. Hedley ML, Gurley J, Urban R. 1998. Microspheres containing plasmid encoded antigens elicit cytotoxic T-cell responses. Nature Med 4:365-368.
17. Jaganathan KS, Vyas SP. 2006. Strong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant hepatitis B antigen administered intranasally. Vaccine 24:4201-4211.
18. Jeffry H, Stanley SS, O'Hagan DT. 1993. The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in water emulsion solvent evaporation technique. Pharm Res 10:362-368.
19. Jones DH, Corris S, McDonald S, Clegg JCS, Farrar GH. 1997. Poly (D,LLactic-co-glycolide) encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration. Vaccine 15:814-817.
20. Klencke B, Matijevic M, Urban RG, Lathey JL, Hedley ML, Berry M, et al.. 2002. Encapsulated plasmid DNA treatment for human papilloma virus 16-associated anal displasia: A phase I study of ZYC101. Clin Cancer Res 8:1028-1037.
21. McClements WL, Armstrong ME, Keys RD, Liu MA. 1996. Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease. Proc Natl Acad Sci USA 93:11414-11420.
22. Mok H, Park TG. 2008. Direct plasmid DNA encapsulation within PLGA nanospheres by single oil-in-water emulsion method. Eur J Pharm Biopharm 68:105-111.
23. O'Donnell PB, McGinity JW. 1997. Preparation of microspheres by the solvent evaporation technique. Adv Drug Deliv Rev 28:25-42.
24. Pandit S, Cevher E, Zariwala MG, Somavarapu S, Alpar HO. 2007. Enhancement of immune response of HBsAg loaded poly (L-lactic acid) microspheres against hepatitis B through incorporation of alum and chitosan. J Microencapsulation 24:539-552.
25. Rosca ID, Watari I, Uo M. 2004. Microparticle formation and its mechanism in single and double emulsion solvent evaporation. J Contr Rel 99:271-280.
26. Sambrook J, Fritsch EF, Maniatis T. 1989. Plasmid vectors. In: Sambrook J, Fritsch EF, Maniatis T, editors. Molecular cloning New York, USA: Cold spring harbor laboratory press. pp 1.33-1.40.
27. Shi L, Caulfield MJ, Chern RT, Wilson RA, Sanyal G, Volkin DB. 2002. Pharmaceutical and immunological evaluation of a single-shot hepatitis B vaccine formulated with PLGA microspheres. J Pharm Sci 91:1019-1035.
28. Singh M, Briones M, Ott G, O'Hagan D. 2000. Cationic microparticles: a potent delivery system for DNA vaccines. Proc Natl Acad Sci USA 97:811-816.
29. Tang DC, DeVith M, Johmston SA. 1992. Genetic immunization is a simple method for eliciting an immune responce. Nature 356:152-154.
30. Tinsley-Brown AM, Fretwell R, Dowsett AB, Davis SL, Farrar GH. 2000. Formulation of poly (D,L-Lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery. J Contr Rel 66:229-241.
31. Tuttenberg A, Jonuleit H, Tüting T, Brück J, Knop J, Enk AH. 2003. Priming of T cells with Ad-transduced DC followed by expansion with peptidepulsed DC significantly enhances the induction of tumor specific CD8 T cells: Implications for an efficient vaccination strategy. Gene Ther 10:243-250.
32. Ulmar JB, Donelly JJ, Parker SE, Rhode GH, Felgner PL, Dwarki V, et al.. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745-1749.
33. Walter E, Moelling K, Pavlovic J, Merkle HP. 1999. Microencapsulation of DNA using poly(D,L-lactic-co-glycolide): Stability issues and release characteristics. J Contr Rel 61:361-374.
34. Wang D, Robinson DR, Kwon GS, Samuel J. 1999. Encapsulation of plasmid DNA in biodegradable poly (D,L-Lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. J Contr Rel 57:9-18.
35. Wang S, Liu X, Fisher K, Smith JG, Chen F, Tobery TW, et al.. 2000. Enhanced type I immune response to a hepatitis B DNA vaccine by formulation with calcium or aluminium phosphate. Vaccine 18:1227-1235.
36. Wolff JA, Dowty ME, Jiao S, Repetto G, Berg RK, Ludtke JJ, et al.. 1992. Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle. J Cell Sci 103:1249-1259.
37. Wolff JA, Malona RW, Williams P, Chong W, Acsadi G, Jani A, et al.. 1990. Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468.
38. Zhang W, Dong SF, Sun SH, Wang Y, Li GD, Qu D. 2006. Coimmunization with IL-15 plasmid enhances the longevity of CD8 T cells induced by DNA encoding hepatitis B virus core antigen. W J Gastroenterol 12:4727-4735.