The effect of process parameters on the size and morphology of poly(D, L-Lactide-Co-Glycolide) micro/nanoparticles prepared by an oil in oil emulsion/solvent evaporation technique

Journal of Applied Polymer Science

Volumn 116, Issue 1, 2010, Pages 528-534

  Mahdavi, Hamid ^a   Mirzadeh, Hamid ^a   Hamishehkar, Hamed ^b   Jamshidi, Ahmad ^a   Fakhari, Amir ^a   Emami, Jaber ^c   Najafabadi, Abdolhossien Rouholamini ^d   Gilani, Kambiz ^d   Minaiyan, Mohsen ^c   Najafi, Mahnaz ^a   Tajarod, Maryam ^a   Nokhodchi, Ali ^e  

^a IRAN POLYMER AND PETROCHEMICAL INSTITUTE   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e MEDWAY SCHOOL OF PHARMACY   (United Kingdom)

Author keywords

Microparticles; Nanoparticles; O O emulsion solvent evaporation; PLGA

Indexed keywords

BIOMEDICAL APPLICATIONS; D , L-LACTIDE; DRUG DELIVERY SYSTEM; EXPERIMENTAL CONDITIONS; HUMAN USE; HYDROPHILIC AGENTS; MEDICAL DEVICES; MICROPARTICLES; PLGA MICROPARTICLES; POLY(D ,L-LACTIDE-CO- GLYCOLIDE); POLYDISPERSITY INDICES; POLYMER CONCENTRATIONS; PROCESS PARAMETERS; REGENERATIVE MEDICINE; RESIDUAL SOLVENT CONTENT; SMOOTH SURFACE; SOLVENT EVAPORATION TECHNIQUES; STIRRING SPEED; SURFACTANT CONCENTRATIONS;

BIODEGRADABLE POLYMERS; CONTROLLED DRUG DELIVERY; EVAPORATION; FUNCTIONAL POLYMERS; NANOPARTICLES; ORGANIC POLYMERS; POLYDISPERSITY; SCANNING ELECTRON MICROSCOPY; SURFACE ACTIVE AGENTS; TISSUE ENGINEERING; VAPORS;

AGGLOMERATION;

BIODEGRADABILITY; BIOMEDICAL USE; DRUG DELIVERY; EMULSION; HYDROPHILIC PROPERTY; IMPLANT; OIL; PARTICLE SIZE; POLYLACTIDE; TISSUE ENGINEERING;

EID: 75449106176     PISSN: 00218995     EISSN: 10974628     Source Type: Journal    
DOI: 10.1002/app.31595     Document Type: Article

References (37)

1. Mundargi, R. C.; Babu, V. R.; Rangaswamy, V.; Patel, P.; Aminabhavi, T. M. J Controlled Release 2008, 125, 193.
2. Panyam, J.; Dali, M. M.; Sahoo, S. K. J Controlled Release 2003, 92, 173.
3. Mu, L.; Feng, S. S. J Controlled Release 2002, 80, 129.
4. Anderson, J. M.; Shive, M. S. Adv Drug Delivery Rev 1997, 28, 5.
5. Jain, R. A. Biomaterials 2000, 21, 2475.
6. Xie, J.; Lim, L. K.; Phua, Y.; Hua, J.; Wang, C. H. J Colloid Interf Sci 2006, 302, 103.
7. Eros, I.; Balázs, J.; Péter, I.; Tacsi, M. Pharmazie 1990, 45, 419 .
8. Zauner, W.; Farrow, N. A.; Haines, A. M. R. J Controlled Release 2001, 71, 39.
9. Takeuchi, H.; Yamamoto, H.; Kawashima, Y. Adv Drug Deliv Rev 2001, 47, 39.
10. Vandervoort, J.; Ludwig, A. Int J Pharm 2002, 238, 77.
11. Davis, S. S.; Illum, L.; Moghimi, S. M.; Davis, M. C., et al. J Controlled Release 1993, 24, 157.
12. Alleman, E.; Gurny, R.; Doelker, E. Eur J Pharm Bioharm 1993, 39, 13.
13. Couvreur, P.; Fattal, E.; Alphandary, H.; Puisieux, F.; Andremont, A. J Controlled Release 1992, 19, 259.
14. Seijo, B.; Fattal, E.; Roblot-Treupel, L.; Couvreur, P. Int J Pharm 1990, 62, 1.
15. Illum, L.; Davis, S. S.; Wilson, C. G.; Frier, M.; Hardy, J. G.; Thomas, N. W. Int J Pharm 1982, 72, 1086.
16. Agu, R. U.; Ugwoke, M. I.; Armand, M.; Kinget, R.; Verbeke, N. Resp Res 2001, 2, 198.
17. Hinds, W. C. Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles; Wiley: New York, 1999; 42.
18. Gonda, I. J Pharm Sci 2000, 89, 940.
19. Heyder, J.; Gebhart, J.; Rudolf, G.; Schiller, C. F.; Stahlhofen, W. J Aerosol Sci 1986, 17, 811.
20. Freitas, S.; Merkle, H. P.; Gander, B. J Controlled Release 2005, 102, 313.
21. Koegler, W. S.; Patrick, C.; Cima, M. J.; Griffith, L. G. J Biomed Mater Res 2002, 63, 567.
22. Mumper, R. J.; Jay, M. Pharm Res 1992, 9, 149.
23. Emami, J.; Hamishehkar, H.; Najafabadi, A. R.; Gilani, K.; Minaiyan, M.; Mahdavi, H.; Nokhodchi, A. J Pharm Sci 2009, 98, 1712.
24. Quintanar-Guerrero, D.; Fessi, H.; Allemann, E.; Doelker, E. Int J Pharm 1996, 143, 133.
25. Murakami, H.; Kobayashi, M.; Takeuchi, H.; Kawashima, Y. Int J Pharm 1999, 187, 143.
26. Kwon, H. Y.; Lee, J. Y.; Choi, S. W.; Jang, Y. Colloids Surf A: Physicochemical Eng Asp 2001, 182, 123.
27. Chorny, M.; Fishbein, I.; Danenberg, H. D.; Golomb, G. J Controlled Release 2002, 83, 389.
28. Wu, X. S. Artif Cells Blood Substit Immobil Biotechnol 2004, 32, 575.
29. Mainardes, R. M.; Evangelista, R. C. Int J Pharm 2005, 290, 137.
30. Yang, Y. Y.; Chung, T. S. Biomaterials 2001, 22, 231.
31. Rott, N. Annu Rev Fluid Mech 1990, 22, 1.
32. Sansdrap, P.; Mojs, A. J. Int J Pharm 1993, 98, 157.
33. Rafati, H.; Coombes, A. G. A.; Adler, J.; Holland, J.; Davis, S. S. J Controlled Release 1997, 43, 89.
34. Mateovic, T.; Kriznar, B.; Bogataj, M.; Mrhar, A. J Microencapsul 2002, 19, 29.
35. Edward, L. P. Turbulence in Mixing Operations; Wiley-IEEE: New York, 2003.
36. Zielhuis, S. W.; Nijsen, J. F.; Dorland, L.; Krijger, G. C.; Van Het Schip, A. D.; Hennink, W. E. Int J Pharm 2006, 315, 67.
37. The United States Pharmacopoeia, 31th ed.; 2008; 170.