Removal of chloroform from biodegradable therapeutic microspheres by radiolysis

International Journal of Pharmaceutics

Volumn 315, Issue 1-2, 2006, Pages 67-74

  Zielhuis, S W ^a   Nijsen, J F W ^a   Dorland, L ^a   Krijger, G C ^b   van het Schip, A D ^a   Hennink, W E ^c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Chloroform; Holmium; Irradiation; Microspheres; PLLA; Residual solvents

Indexed keywords

CHLORIDE; CHLOROFORM; HOLMIUM; HOLMIUM ACETYLACETONATE; MICROSPHERE; PHOSGENE; PLACEBO; POLYLACTIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADABILITY; CHEMICAL ANALYSIS; CRYSTALLIZATION; DEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SYNTHESIS; ENERGY; EVALUATION; GAMMA IRRADIATION; GAS CHROMATOGRAPHY; GEL PERMEATION CHROMATOGRAPHY; IRRADIATION; MASS SPECTROMETRY; MOLECULAR WEIGHT; MORPHOLOGY; NEUTRON RADIATION; PRECIPITATION; PRIORITY JOURNAL; RADIATION DOSE; RADIOLYSIS; SYNTHESIS; TITRIMETRY;

BIODEGRADATION, ENVIRONMENTAL; CHLOROFORM; DRUG CONTAMINATION; GAMMA RAYS; HOLMIUM; LACTIC ACID; MICROSPHERES; MOLECULAR WEIGHT; NEUTRONS; POLYMERS; RADIOISOTOPES;

EID: 33646336893     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.02.010     Document Type: Article

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