New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 4, 2010, Pages 1344-1346

  Hegde, Vinod R ^a   Borges, Scott ^a   Patel, Mahesh ^a   Das, Pradip R ^a   Wu, Bonnie ^a   Gullo, Vincent P ^a   Chan, Tze Ming ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aristolochic acid; CDK2 inhibitors; Natural products; Separation; Structure determination

Indexed keywords

ANTINEOPLASTIC AGENT; ARISTOLOCHIA MANSHURIENSIS EXTRACT; CYCLIN DEPENDENT KINASE 2 INHIBITOR; PHENANTHRENE DERIVATIVE; PLANT EXTRACT; PLANT GLYCOSIDE; SCH 546909; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARISTOLOCHIA; ARISTOLOCHIA MANSHURIENSIS; ARTICLE; DRUG POTENCY; ENZYME INHIBITION; IC 50;

ANTINEOPLASTIC AGENTS; ARISTOLOCHIA; CYCLIN-DEPENDENT KINASE 2; DRUGS, CHINESE HERBAL; ENZYME ACTIVATION; GLYCOSIDES; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; METHANOL; MOLECULAR STRUCTURE; PLANT EXTRACTS; WATER;

ARISTOLOCHIA MANSHURIENSIS;

EID: 75449096843     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.018     Document Type: Article

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