-
2
-
-
0028931265
-
Principles of CDK regulation
-
(1995)
Nature
, vol.374
, pp. 131-134
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-
Morgan1
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3
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-
0029317904
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Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle
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(1995)
Bioessays
, vol.17
, pp. 471-480
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Nigg1
-
4
-
-
0027336491
-
Mammalian G1 cyclins
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(1993)
Cell
, vol.73
, pp. 1059-1065
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-
Sherr1
-
7
-
-
0028918028
-
Transcriptional regulation during the mammalian cell cycle
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(1995)
Trends Genet
, vol.11
, pp. 173-178
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-
Muller1
-
8
-
-
0029033504
-
Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast
-
(1995)
Cell
, vol.81
, pp. 269-277
-
-
Irniger1
Piatti2
Michaelis3
Nasmyth4
-
10
-
-
0029028237
-
CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphse to anaphase transition
-
(1995)
Cell
, vol.81
, pp. 261-268
-
-
Tugendreich1
Tomkiel2
Earnshaw3
Hieter4
-
11
-
-
0029051233
-
Cyclin ubiquitination: the destructive end of mitosis
-
(1995)
Cell
, vol.81
, pp. 149-152
-
-
Murray1
-
13
-
-
0029029617
-
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
-
of outstanding interest, This elegant study reports the solution of a cyclin A—CDK2 co-crystal, providing a structural basis for cyclin activation of the CDKs.
-
(1995)
Nature
-
-
Jeffrey1
Russo2
Polyak3
Gibbs4
Hurwitz5
Massague6
Pavletich7
-
18
-
-
0027185999
-
CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15
-
(1993)
EMBO J
, vol.12
, pp. 3133-3142
-
-
Solomon1
Harper2
Shuttleworth3
-
19
-
-
0027994603
-
A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase
-
of special interest, Cloning of the gene encoding cyclin H (which is a component of CAK) demonstrated that CDKs are indeed regulated by other cyclin—CDK-type complexes.
-
(1994)
Cell
, vol.78
, pp. 713-724
-
-
Fisher1
Morgan2
-
21
-
-
0028168543
-
Expression and activity of p40MO15, the catalytic subunit of cdk-activating kinase, during Xenopus oogenesis and embryogenesis
-
(1994)
Mol Biol Cell
, vol.5
, pp. 921-932
-
-
Brown1
Jones2
Shuttleworth3
-
22
-
-
0028089946
-
Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)
-
(1994)
J Cell Biol
, vol.127
, pp. 467-478
-
-
Tassan1
Schultz2
Bartek3
Nigg4
-
24
-
-
84910916086
-
MAT1 ('menage à trois') a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.
-
in press
-
(1995)
EMBO J
-
-
Devault1
Doree2
-
25
-
-
0028590113
-
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
-
of special interest, This demonstration that KIN28 was a component of TFIIH in yeast and possesses carboxy-terminal domain (CTD) kinase activity led to a flurry of papers, all demonstrating that CAK contained CTD kinase activity. This paper also raised the issue of CAK function in transcription.
-
(1994)
Cell
, vol.79
, pp. 1103-1109
-
-
Feaver1
Svejstrup2
Henry3
Kornberg4
-
26
-
-
0028600051
-
The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor
-
of special interest, This study describes the identification of p40MO15 as a component of TFIIH. With [25], it set a precedent by deciding that CAK has CTD kinase activity.
-
(1994)
Cell
, vol.79
, pp. 1093-1101
-
-
Roy1
Adamczewski2
Seroz3
Vermeulen4
Tassan5
Schaeffer6
Nigg7
Hoeijmakers8
Egly9
-
27
-
-
0029066929
-
KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2983-2992
-
-
Cismowski1
Laff2
Solomon3
Reed4
-
33
-
-
0028022034
-
Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition
-
(1994)
EMBO J
, vol.13
, pp. 4302-4310
-
-
Hoffmann1
Draetta2
Karsenti3
-
35
-
-
0029042689
-
Raf1 interaction with cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation
-
(1995)
Genes Dev
, vol.9
, pp. 1046-1058
-
-
Galaktionov1
Jessus2
Beach3
-
40
-
-
0028988585
-
Inhibitors of mammalian G1 cyclin-dependent kinases
-
(1995)
Genes Dev
, vol.9
, pp. 1149-1163
-
-
Sherr1
Roberts2
-
41
-
-
0027769876
-
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
-
(1993)
Nature
, vol.366
, pp. 704-707
-
-
Serrano1
Hannon2
Beach3
-
43
-
-
0028168242
-
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
-
of outstanding interest, This paper discusses the isolation of p15 and induction of RNA levels in response to TGFβ. Significantly, this was the first demonstration of a cytokine-inducible inhibitor.
-
(1994)
Nature
, vol.371
, pp. 257-261
-
-
Hannon1
Beach2
-
44
-
-
0028121279
-
A cell cycle regulator potentially involved in genesis of many tumor types
-
of outstanding interest, Genetic linkage analysis of families with hereditary melanoma located a potential tumor suppressor gene on human chromosome 9p21. Interestingly, isolation of this gene revealed its identity to p16 and thus provided the first clues that p16 may function as a tumor suppressor gene.
-
(1994)
Science
, vol.264
, pp. 436-440
-
-
Kamb1
Gruis2
Weaver3
Liu4
Harshman5
Tavtigian6
Stockert7
Day8
Johnson9
Skolnick10
-
48
-
-
0028034775
-
Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb
-
(1994)
Cancer Res
, vol.54
, pp. 6078-6082
-
-
Li1
Nichols2
Shay3
Xiong4
-
54
-
-
0028126668
-
Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4
-
(1994)
Cancer Res
, vol.54
, pp. 5816-5820
-
-
Tam1
Shay2
Pagano3
-
56
-
-
0029153609
-
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β
-
of special interest, Study of the activities of cell cycle inhibitor proteins in response to TGFβ suggests the involvement of both p15 and p27 in the execution of the proliferation block induced by TGFβ.
-
(1995)
Genes Dev
-
-
Reynisdottir1
Polyak2
Iavarone3
Massague4
-
57
-
-
0028176483
-
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
-
of special interest, The isolation of p27 revealed that there is a family of cell cycle inhibitory proteins that includes p27 and p21. The authors demonstrated that although the CDK inhibitory domains are conserved, p27 lacks sequences required for binding PCNA.
-
(1994)
Cell
, vol.78
, pp. 59-66
-
-
Polyak1
Lee2
Erdjument3
Koff4
Roberts5
Tempst6
Massague7
-
63
-
-
0028342664
-
Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen
-
of outstanding interest, This paper describes the isolation of p21 as a gene that was present and induced in senescent cells. Subtractive library screening was used.
-
(1994)
Experimental Cell Research
, vol.211
, pp. 90-98
-
-
Noda1
Ning2
Venable3
Pereira4
Smith5
-
65
-
-
0028352434
-
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
-
(1994)
Nature
, vol.369
, pp. 574-578
-
-
Waga1
Hannon2
Beach3
Stillman4
-
70
-
-
0028169236
-
p21-containing cyclin kinases exist in both active and inactive states
-
(1994)
Genes Dev
, vol.8
, pp. 1750-1758
-
-
Zhang1
Hannon2
Beach3
-
74
-
-
0028928036
-
Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase
-
(1995)
Science
, vol.267
, pp. 1022-1024
-
-
Skapek1
Rhee2
Spicer3
Lassar4
-
75
-
-
84910880209
-
-
El-Diery WS, Tokino T, Waldman T, Oliner JD, Velculescu VE, Burrell M, Hill DE, Healy E, Rees JL, Hamilton SR: Topological control of p21WAF-1 expression in normal and neoplastic tissues. In press.
-
-
-
-
78
-
-
0028363519
-
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
-
of special interest, This study details the isolation of p27 by two hybrid yeast screens using cyuclin D—CDK4 as a bait. The p27 protein was shown to be associated with cyclin—CDC complexes in vivo.
-
(1994)
Cell
, vol.78
, pp. 67-74
-
-
Toyoshima1
Hunter2
-
85
-
-
0027301324
-
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation
-
(1993)
Genes Dev
, vol.7
, pp. 1572-1583
-
-
Xiong1
Zhang2
Beach3
-
90
-
-
0028986043
-
p13suc1 of Schizosaccharomyces pombe regulates two distinct forms of the mitotic cdc2 kinase
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2028-2036
-
-
Basi1
Draetta2
-
93
-
-
0028072520
-
Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle
-
(1994)
Cell
, vol.79
, pp. 181-184
-
-
Peter1
Herskowitz2
-
95
-
-
0028206855
-
An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells
-
(1994)
Mol Cell Biol
, vol.14
, pp. 3320-3328
-
-
Nugroho1
Mendenhall2
-
96
-
-
0028085427
-
Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1
-
(1994)
Science
, vol.265
, pp. 1228-1231
-
-
Peter1
Herskowitz2
-
97
-
-
0028052088
-
Phosphate-regulated inactivation of the kinase PHO80-PHO85 by the CDK inhibitor PHO81
-
of special interest, This paper showed that PHO81 is related to the INK4 family of mammalian inhibitors by virtue of its ankyrin repeats, and that it could inhibit a cyclin-CDK complex in a similar fashion. This was the first demonstration of the conservation of inhibitor mechanisms between yeast and mammals.
-
(1994)
Science
, vol.266
, pp. 122-126
-
-
Schneider1
Smith2
O'Shea3
-
98
-
-
0028114987
-
SIC1 controls the G1 to S transition in S. cerevisiae
-
of special interest, This paper shows that p40SIC1 has to be degraded (by a ubiquitin-directed method) to enable cells to begin DNA synthesis. Levels of p40SIC1 therefore limit the rate of cell cycle progression.
-
(1994)
Cell
, vol.79
, pp. 233-244
-
-
Schwob1
Bohm2
Mendenhall3
Nasmyth4
-
99
-
-
0027244234
-
Human Wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
-
(1993)
Cell
, vol.74
, pp. 463-474
-
-
Heald1
McLoughlin2
McKeon3
-
101
-
-
0029019737
-
Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus
-
(1995)
EMBO J
, vol.14
, pp. 1646-1654
-
-
Jackman1
Firth2
Pines3
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