Size-dependent release of fluorescent macromolecules and nanoparticles from radically cross-linked hydrogels

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 74, Issue 2, 2010, Pages 184-192

  Henke, Matthias ^a   Brandl, Ferdinand ^a   Goepferich, Achim M ^a   Tessmar, Joerg K ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Characterization; FRAP; Hydrogel; Macromolecular drugs; Nanoparticle; Release; Thermally cross linkable

Indexed keywords

DRUG CARRIER; MACROGOL; NANOPARTICLE; OLIGO[POLY(ETHYLENE GLYCOL)FUMARATE]; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CROSS LINKING; FLOW MEASUREMENT; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HYDROGEL; MACROMOLECULE; MOLECULAR WEIGHT; NANOPROBE; PARTICLE SIZE; PHYSICAL PARAMETERS; POLYMERIZATION;

CROSS-LINKING REAGENTS; DRUG CARRIERS; DRUG COMPOUNDING; FLUORESCENT DYES; HYDROGELS; NANOPARTICLES; PARTICLE SIZE; PHYSICOCHEMICAL PHENOMENA; POLYESTERS; POLYETHYLENE GLYCOLS;

EID: 75449083387     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2009.08.011     Document Type: Article

References (29)

1. Brandl F., Sommer F., and Goepferich A. Rational design of hydrogels for tissue engineering: impact of physical factors on cell behaviour. Biomaterials 28 (2007) 134-146
2. Jo S., Shin H., Shung A.K., Fischer J.P., and Mikos A.G. Synthesis and characterization of oligo(poly(ethylene glycol) fumarate) macromer. Macromolecules 34 (2001) 2839-2844
3. Temenoff J.S., Park H., Jabbari E., Conway D.E., Sheffield T.L., Ambrose C.G., and Mikos A.G. Thermally cross-linked oligo(poly(ethylene glycol) fumarate) hydrogels support osteogenic differentiation of encapsulated marrow stromal cells in vitro. Biomacromolecules 5 (2004) 5-.10
4. Temenoff J.S., Athanasiou K.A., Lebaron R.G., and Mikos A.G. Effect of poly(ethylene glycol) molecular weight on tensile and swelling properties of oligo(poly(ethylene glycol) fumarate) hydrogels for cartilage tissue engineering. Journal of Biomedical Materials Research 59 (2002) 429-437
5. Lutz J.F. Polymerization of oligo(ethylene glycol) (meth)acrylates: towards new generations of smart biocompatible materials. Journal of Polymer Science Part A 46 (2008) 3459-3875
6. Shin H., Jo S., and Mikos A.G. Modulation of marrow stromal osteoblast adhesion on biomimetic oligo[poly(ethylene glycol) fumarate] hydrogels modified with Arg-Gly-Asp peptides and a poly(ethylene glycol) spacer. Journal of Biomedical Materials Research 61 (2002) 169-179
7. Yang F., Williams C.G., -An Wang D., Lee H., Manson P.N., and Elisseeff J. The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells. Biomaterials 26 (2005) 5991-5998
8. Boontheekul T., and Mooney D.J. Protein-based signaling systems in tissue engineering. Current Opinion in Biotechnology 14 (2003) 559-565
9. Chen R.R., and Mooney D.J. Polymeric growth factor delivery strategies for tissue engineering. Pharmaceutical Research 20 (2003) 1103-1112
10. Brandl F., Henke M., Rothschenk S., Gschwind R., Breunig M., Blunk T., Tessmar J., and Göpferich A. Poly(ethylene glycol) based hydrogels for intraocular applications. Advanced Engineering Materials 9 (2007) 1141-1149
11. Hoare T.R., and Kohane D.S. Hydrogels in drug delivery: progress and challenges. Polymer 49 (2008) 1993-2007
12. Chen S.-C., Wu Y.-C., Mi F.-L., Lin Y.-H., Yu L.-C., and Sung H.-W. A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. Journal of Controlled Release 96 (2004) 285-300
13. Jones D.S., Lorimer C.P., McCoy C.P., and Gorman S.P. Characterization of the physicochemical, antimicrobial, and drug release properties of thermoresponsive hydrogel copolymers designed for medical device applications. Journal of Biomedical Materials Research Part B: Applied Biomaterials 85B (2008) 417-426
14. Roos A.A., Edlund U., Sjöberg J., Albertsson A.-C., and Stålbrand H. Protein release from galactoglucomannan hydrogels: influence of substitutions and enzymatic hydrolysis by ß-Mannanase. Biomacromolecules 9 (2008) 2104-2110
15. Coughlan D.C., Quilty F.P., and Corrigan O.I. Effect of drug physicochemical properties on swelling/deswelling kinetics and pulsatile drug release from thermoresponsive poly(N-isopropylacrylamide) hydrogels. Journal of Controlled Release 98 (2004) 97-114
16. Holland T.A., Tabata Y., and Mikos A.G. In vitro release of transforming growth factor-ß1 from gelatin microparticles encapsulated in biodegradable, injectable oligo(poly(ethylene glycol) fumarate) hydrogels. Journal of Controlled Release 91 (2003) 299-313
17. Chung Y.-I., Ahn K.-M., Jeon S.-H., Lee S.-Y., Lee J.-H., and Tae G. Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex. Journal of Controlled Release 121 (2007) 91-99
18. Holland T.A., Tabata Y., and Mikos A.G. Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering. Journal of Controlled Release 101 (2005) 111-125
19. Kasper F.K., Kushibiki T., Kimura Y., Mikos A.G., and Tabata Y. In vivo release of plasmid DNA from composites of oligo(poly(ethylene glycol)fumarate) and cationized gelatin microspheres. Journal of Controlled Release 107 (2005) 547-561
20. Park H., Temenoff J.S., Tabata Y., Caplan A., Raphael R.M., Jansen J.A., and Mikos A.G. Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites. Journal of Biomedical Materials Research Part A 88A (2009) 889-897
21. Temenoff J.S., Park H., Jabbari E., Sheffield T.L., LeBaron R.G., Ambrose C.G., and Mikos A.G. In vitro osteogenic differentiation of marrow stromal cells encapsulated in biodegradable hydrogels. Journal of Biomedical Materials Research, Part A 70A (2004) 235-244
22. Dadsetan M., Szatkowski J.P., Yaszemski M.J., and Lu L. Characterization of photo-cross-linked oligo[poly(ethylene glycol) fumarate] hydrogels for cartilage tissue engineering. Biomacromolecules 8 (2007) 1702-1709
23. Canal T., and Peppas N.A. Correlation between mesh size and equilibrium degree of swelling of polymeric networks. Journal of Biomedical Materials Research 23 (1989) 1183-1193
24. Fänger C., Wack H., and Ulbricht M. Macroporous poly(N-isopropylacrylamide) hydrogels with adjustable size cut-off for the efficient and reversible immobilization of biomacromolecules. Macromolecular Bioscience 6 (2006) 393-402
25. Billmeyer Jr. F.W. Textbook of Polymer Science. third ed. (1984), John wiley & Sons, New York p. 158
26. Soumpasis D.M. Theoretical analysis of fluorescence photobleaching. Biophysical Journal 41 (1983) 95-97
27. Timmer M.D., Jo S., Wang C., Ambrose C.G., and Mikos A.G. Characterization of the cross-linked structure of fumarate-based degradable polymer networks. Macromolecules 35 (2002) 4373-4379
28. Product Information for fluorescein isothiocyanate dextrans, Sigma-Aldrich, downloaded March 2009
29. Braeckmans K., Peeters L., Sanders N.N., De Smedt S.C., and Demeester J. Three-dimensional fluorescence recovery after photobleaching with the confocal scanning laser microscope. Biophysical Journal 85 (2003) 2240-2252