Water-soluble platinum(II) complexes of diamine chelating ligands bearing amino-acid type substituents: The effect of the linked amino acid and the diamine chelate ring size on antitumor activity, and interactions with 5′-GMP and DNA

Journal of Inorganic Biochemistry

Volumn 98, Issue 11, 2004, Pages 1933-1946

  Moradell, Silvia ^a   Lorenzo, Julia ^b   Rovira, Ana ^b   Van Zutphen, Steven ^c   Avilés, Francesc X ^b   Moreno, Virtudes ^d   De Llorens, Rafael ^a   Martinez, M Angeles ^a   Reedijk, Jan ^c   Llobet, Antoni ^a  

^a UNIVERSITY OF GIRONA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c LEIDEN UNIVERSITY   (Netherlands)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Amino acid substituents; Anticancer drugs; Cisplatin; DNA interactions; GMP interactions

Indexed keywords

ALANINE; AMINO ACID; CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; CHELATING AGENT; DIAMINE DERIVATIVE; DICHLORO[2 (1,2 DIAMINOETHYLCARBOXIAMIDE) 3 PHENYLPROPIONIC ACID]PLATINUM; DICHLORO[2 (1,2 DIAMINOETHYLCARBOXIAMIDE)PROPIONATE METHYL ESTER]PLATINUM; DICHLORO[2 (1,2 DIAMINOETHYLCARBOXIAMIDE)PROPIONIC ACID]PLATINUM; DICHLORO[2 (1,3 DIAMINOPROPYLCARBOXIAMIDE) 3 PHENYLPROPIONIC ACID]PLATINUM; DICHLORO[2 (1,3 DIAMINOPROPYLCARBOXIAMIDE)PROPIONATE METHYL ESTER]PLATINUM; DICHLORO[2 (1,3 DIAMINOPROPYLCARBOXIAMIDE)PROPIONIC ACID]PLATINUM; DNA; ESTER DERIVATIVE; GUANOSINE PHOSPHATE; LIGAND; PHENYLALANINE; PLATINUM COMPLEX; PURINE; UNCLASSIFIED DRUG; WATER;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HL 60; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DNA STRUCTURE; DRUG DNA INTERACTION; DRUG STRUCTURE; HELA CELL; HUMAN; HUMAN CELL; MONITORING; NUCLEAR MAGNETIC RESONANCE; SEQUENCE ANALYSIS; SOLUBILITY; SPECTROSCOPY; STRUCTURE ANALYSIS; TIME;

5'-GUANYLIC ACID; AMINO ACIDS; DIAMINES; DNA; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; ORGANOPLATINUM COMPOUNDS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 7544232697     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2004.08.011     Document Type: Article

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