(Aminoethanol)dichloroplatinum(II) complexes: Influence of the hydroxyethyl moiety on 5′-GMP and DNA binding, intramolecular stability, the partition coefficient and anticancer activity

Journal of Inorganic Biochemistry

Volumn 88, Issue 3-4, 2002, Pages 254-259

  Robillard, Marc S ^a   Galanski, Mathea S ^b   Zimmermann, Wolfgang ^b   Keppler, Bernard K ^b   Reedijk, Jan ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Aminoethanol complexes; Cisplatin; Cytotoxicity; DNA; GMP

Indexed keywords

(AMINOETHANOL)DICHLOROPLATINUM COMPLEX; CISPLATIN; DICHLOROBIS(2 HYDROXYETHYLAMINE)PLATINUM; DICHLORO[N (2 HYDROXYETHYL)ETHYLENEDIAMINE]PLATINUM; DICHLORO[N,N' BIS(2 HYDROXYETHYL)ETHYLENEDIAMINE]PLATINUM; ETHANOLAMINE DERIVATIVE; GUANOSINE PHOSPHATE; HYDROXYETHYL GROUP; HYDROXYL GROUP; OCTANOL; PLATINUM COMPLEX; UNCLASSIFIED DRUG; WATER;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL REACTION; CLONOGENIC ASSAY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA ADDUCT; DRUG CYTOTOXICITY; DRUG DNA INTERACTION; DRUG STABILITY; HUMAN; HUMAN CELL; LIFESPAN; LIPOPHILICITY; PARTITION COEFFICIENT; PH; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR CELL CULTURE;

EID: 0036196355     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-0134(01)00362-2     Document Type: Article

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