Structure-based discovery of small molecules targeting different surfaces of protein-kinase CK2

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1804, Issue 3, 2010, Pages 493-498

  Prudent, Renaud ^a   Sautel, Céline F ^a   Cochet, Claude ^a  

^a CEA GRENOBLE   (France)

Author keywords

Allosteric inhibition; Non competitive inhibitor; Protein kinase CK2; Protein protein interaction

Indexed keywords

4,5,6,7 TETRABROMOBENZOTRIAZOLE; [5 OXO 5,6 DIHYDROINDOLO (1,2 A)QUINAZOLIN 7 YL] ACETIC ACID; ANTINEOPLASTIC AGENT; CASEIN KINASE II; CASEIN KINASE II ALPHA; CASEIN KINASE II INHIBTOR; PODOPHYLLOTOXINE INDOLO DERIVATIVE; POLYXOMETALATE; QUERCETIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CATALYSIS; CHEMICAL STRUCTURE; DRUG EFFECT; DRUG POTENCY; DRUG TARGETING; HUMAN; MOLECULE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW;

ANIMALS; CASEIN KINASE II; CATALYTIC DOMAIN; HUMANS; NEOPLASMS; PROTEIN SYNTHESIS INHIBITORS; TUMOR MARKERS, BIOLOGICAL; TUNGSTEN COMPOUNDS;

EID: 75349110581     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2009.09.003     Document Type: Review

References (27)

1. Tawfic S., Yu S., Wang H., Faust R., Davis A., and Ahmed K. Protein kinase CK2 signal in neoplasia. Histol. Histopathol. 16 (2001) 573-582
2. Faust M., and Montenarh M. Subcellular localization of protein kinase CK2. A key to its function?. Cell Tissue Res. 301 (2000) 329-340
3. Duncan J.S., and Litchfield D.W. Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2. Biochim. Biophys. Acta 1784 (2008) 33-47
4. Laramas M., Pasquier D., Filhol O., Ringeisen F., Descotes J.L., and Cochet C. Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer. Eur. J. Cancer 43 (2007) 928-934
5. O.c. P., Rusch V., Talbot S.G., Sarkaria I., Viale A., Socci N., Ngai I., Rao P., and Singh B. Casein kinase II alpha subunit and C1-inhibitor are independent predictors of outcome in patients with squamous cell carcinoma of the lung. Clin. Cancer Res. 10 (2004) 5792-5803
6. Kim J.S., Eom J.I., Cheong J.W., Choi A.J., Lee J.K., Yang W.I., and Min Y.H. Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia. Clin. Cancer Res. 13 (2007) 1019-1028
7. Sarno S., de Moliner E., Ruzzene M., Pagano M.A., Battistutta R., Bain J., Fabbro D., Schoepfer J., Elliott M., Furet P., Meggio F., Zanotti G., and Pinna L.A. Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). Biochem. J. 374 (2003) 639-646
8. Pagano M.A., Andrzejewska M., Ruzzene M., Sarno S., Cesaro L., Bain J., Elliott M., Meggio F., Kazimierczuk Z., and Pinna L.A. Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J. Med. Chem. 47 (2004) 6239-6247
9. Meggio F., Pagano M.A., Moro S., Zagotto G., Ruzzene M., Sarno S., Cozza G., Bain J., Elliott M., Deana A.D., Brunati A.M., and Pinna L.A. Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study. Biochemistry 43 (2004) 12931-12936
10. Vangrevelinghe E., Zimmermann K., Schoepfer J., Portmann R., Fabbro D., and Furet P. Discovery of a potent and selective protein kinase CK2 inhibitor by high-throughput docking. J. Med. Chem. 46 (2003) 2656-2662
11. Sarno S., Salvi M., Battistutta R., Zanotti G., and Pinna L.A. Features and potentials of ATP-site directed CK2 inhibitors. Biochim. Biophys. Acta 1754 (2005) 263-270
12. Sarno S., Ghisellini P., and Pinna L.A. Unique activation mechanism of protein kinase CK2. The N-terminal segment is essential for constitutive activity of the catalytic subunit but not of the holoenzyme. J. Biol. Chem. 277 (2002) 22509-22514
13. Sarno S., Moro S., Meggio F., Zagotto G., Dal Ben D., Ghisellini P., Battistutta R., Zanotti G., and Pinna L.A. Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol. Ther. 93 (2002) 159-168
14. Prudent R., Lopez-Ramos M., Moucadel V., Barette C., Grierson D., Mouawad L., Florent J.C., Lafanechere L., Schmidt F., and Cochet C. Salicylaldehyde derivatives as new protein kinase CK2 inhibitors. Biochim. Biophys. Acta 1780 (2008) 1412-1420
15. Prudent R., Moucadel V., Laudet B., Barette C., Lafanechere L., Hasenknopf B., Li J., Bareyt S., Lacote E., Thorimbert S., Malacria M., Gouzerh P., and Cochet C. Identification of polyoxometalates as nanomolar noncompetitive inhibitors of protein kinase CK2. Chem. Biol. 15 (2008) 683-692
16. Laudet B., Barette C., Dulery V., Renaudet O., Dumy P., Metz A., Prudent R., Deshiere A., Dideberg O., Filhol O., and Cochet C. Structure-based design of small peptide inhibitors of protein kinase CK2 subunit interaction. Biochem. J. 408 (2007) 363-373
17. Laudet B., Moucadel V., Prudent R., Filhol O., Wong Y.S., Royer D., and Cochet C. Identification of chemical inhibitors of protein-kinase CK2 subunit interaction. Mol. Cell. Biochem. 316 (2008) 63-69
18. Pope M.T. Introduction to polyoxometalate chemistry. In: Borras-Almenar J.J., Coronado E., Müller A., and Pope M.T. (Eds). Polyoxometalate Molecular Science 98 (2003), Kluwer Academic Publishers, Dordrecht 3-31
19. Kornev A.P., Taylor S.S., and Ten Eyck L.F. A helix scaffold for the assembly of active protein kinases. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 14377-14382
20. Niefind K., Guerra B., Ermakowa I., and Issinger O.G. Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. EMBO J. 20 (2001) 5320-5331
21. Filhol O., Nueda A., Martel V., Gerber-Scokaert D., Benitez M.J., Souchier C., Saoudi Y., and Cochet C. Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits. Mol. Cell. Biol. 23 (2003) 975-987
22. Guerra B., Niefind K., Pinna L.A., Schomburg D., and Issinger O.G. Expression, purification and crystallization of the catalytic subunit of protein kinase CK2 from Zea mays. Acta Crystallogr. D Biol. Crystallogr. 54 (1998) 143-145
23. Filhol O., Martiel J.L., and Cochet C. Protein kinase CK2: a new view of an old molecular complex. EMBO Rep. 5 (2004) 351-355
24. Filhol O., and Cochet C. Cellular functions of protein kinase CK2: a dynamic affair. Cell. Mol. Life Sci. 66 (2009) 1830-1839
25. Raaf J., Brunstein E., Issinger O.G., and Niefind K. The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules. Chem. Biol. 15 (2008) 111-117
26. Prudent R., and Cochet C. New protein kinase CK2 inhibitors: jumping out of the catalytic box. Chem. Biol. 16 (2009) 112-120
27. Masterson L.R., Mascioni A., Traaseth N.J., Taylor S.S., and Veglia G. Allosteric cooperativity in protein kinase A. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 506-511