Does narcolepsy symptom severity vary according to HLA-DQB1*0602 allele status?

Sleep

Volumn 33, Issue 1, 2010, Pages 29-35

  Watson, Nathaniel F ^a   Ton, Thanh G N ^a   Koepsell, Thomas D ^a   Gersuk, Vivian H ^b   Longstreth Jr , W T ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

Cataplexy; HLA DQB1*0602; Narcolepsy; Symptoms

Indexed keywords

GENOMIC DNA; HLA DQB1 ANTIGEN;

ADULT; AFRICAN AMERICAN; ALLELE; ARTICLE; CATAPLEXY; CAUCASIAN; CLINICAL FEATURE; DISEASE SEVERITY; EPWORTH SLEEPINESS SCALE; FEMALE; GENETIC ASSOCIATION; GENOMICS; HLA SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NARCOLEPSY; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; RACE DIFFERENCE; SCORING SYSTEM; SLEEP; SLEEP PARAMETERS; SOMNOLENCE; TRAFFIC ACCIDENT; ULLANLINNA NARCOLEPSY SCALE; UNITED STATES;

EID: 75149193284     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.1093/sleep/33.1.29     Document Type: Article

References (48)

1. Dement WC, Zarcone V. The prevalence of narcolepsy (abstract). Sleep Res 1972;1:148.
2. Dement WC, Carskadon MA, Ley R. The prevalence of narcolepsy II (abstract). Sleep Res 1973;2:147.
3. Solomon P. Narcolepsy in Negroes. Dis Nerv Syst 1945;6:179-83.
4. Silber MH, Krahn LE, Olson EJ, Pankratz VS. The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study. Sleep 2002;25:197-202.
5. Longstreth WT Jr, Ton TG, Koepsell T, Gersuk VH, Hendrickson A, Velde S. Prevalence of narcolepsy in King County, Washington, USA. Sleep Medi 2008;10:422-6.
6. Yoss RE, Daly DD. Criteria for the diagnosis of the narcoleptic syndrome. Mayo ClinProc 1957;32:320-8.
7. Wise MS, Arand DL, Auger RR Brooks SN, Watson NF. Treatment of narcolepsy and other hypersomnias of central origin. Sleep 2007;30:1712-27.
8. Peyron C, Faraco J, Rogers W, et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000;6:991-7.
9. Thannickal TC, Moore RY, Nienhuis R et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000;27:469-74.
10. Mignot E, Lammers GJ, Ripley B, et al. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol 2002;59:1553-62.
11. Dauvilliers Y, Carlander B, Molinari N, et al. Month of birth as a risk factor for narcolepsy. Sleep 2003;26:663-5.
12. Wing YK, Chen L, Fong SY, et al. Narcolepsy in Southern Chinese patients: clinical characteristics, HLA typing and seasonality of birth. J Neurol, Neurosurg Psychiatry 2008;79:1262-7.
13. Overeem S, Black JL 3rd, Lammers GJ. Narcolepsy: immunological aspects. Sleep Med Rev 2008;12:95-107.
14. Mignot E, Lin L, Rogers W, et al. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet 2001;68:686-99.
15. Hallmayer J, Faraco J, Lin L, et al. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet 2009;3:708-11.
16. Cournu-Rebeix I, Genin E, Leray E, et al. HLA-DRB1*15 allele influences the later course of relapsing remitting multiple sclerosis. Genes Immun 2008;9:570-4.
17. Smestad C, Brynedal B, Jonasdottir G, et al. The impact of HLA-A and -DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients. Eur J Neurol 2007;14:835-40.
18. Furuya T, Hakoda M, Ichikawa N, et al. Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis. Clin Rheumatol 2007;26:2137-41.
19. Hodgkinson AD, Millward BA, Demaine AG. The HLA-E locus is associated with age at onset and susceptibility to type 1 diabetes mellitus. Hum Immunol 2000;61:290-5.
20. Ma SL, Tang NL, Tarn CW, et al. Association between HLA-A alleles and Alzheimer's disease in a southern Chinese community. Dement Geriatr Cogn Disord 2008;26:391-7.
21. Choukri F, Chakib A, Himmich H, Marih L, Caillat-Zucman S. HLA-B phenotype modifies the course of Behcet's disease in Moroccan patients. Tissue Antigens 2003;61:92-6.
22. Taurog JD, Maika SD, Simmons WA, Breban M, Hammer RE. Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression. J Immunol 1993;150:4168-78.
23. Wen L, Wong FS, Tang J, et al. In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes. J Exp Med 2000;191:97-104.
24. Pelin Z, Guilleminault C, Risch N, Grumet FC, Mignot E. HLADQB 1*0602 homozygosity increases relative risk for narcolepsy but not disease severity in two ethnic groups. US Modafinil in Narcolepsy Multicenter Study Group. Tissue Antigens 1998;51:96-100.
25. Mignot E, Kimura A, Lattermann A, et al. Extensive HLA class II studies in 58 non-DRBl*15 (DR2) narcoleptic patients with cataplexy. Tissue Antigens 1997;49:329-41.
26. Barcellos LF, Oksenberg JR, Begovich AB, et al. HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am J Hum Genet 2003;72:710-6.
27. Masterman T, Ligers A, Olsson T, Andersson M, Olerup O, Hillert J. HLA-DR15 is associated with lower age at onset in multiple sclerosis. Ann Neurol 2000;48:211-9.
28. Okuda DT, Srinivasan R, Oksenberg JR, et al. Genotype-Phenotype correlations inmultiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures. Brain 2009;132:250-9.
29. Anic-Labat S, GuiUeminault C, Kraemer HC, Meehan J, Arrigoni J, Mignot E. Validation of a cataplexy questionnaire in 983 sleep-disorders patients. Sleep 1999;22:77-87.
30. Hauri PJ, ed. International classification of sleep disorders-2: diagnostic & coding manual. Second ed. Westchester, IL: American Academy of Sleep Medicine, 2005.
31. Gallup Organization. Omnibus Sleep in America Poll (Sponsored by NSF). Princeton, NJ: Gallup Organization, 1997.
32. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991;14:540-5.
33. Hublin C, Kaprio J, Partinen M, Koskenvuo M, Heikkila K. The Ullanlinna Narcolepsy Scale: validation of a measure of symptoms in the narcoleptic syndrome. J Sleep Res 1994;3:52-9.
34. NHANES I Epidemiologic follow-up study. In: National Center for Health Statistics.
35. Douglass AB, Bornstein R, Nino-Murcia G, et al. The Sleep Disorders Questionnaire. I: Creation and multivariate structure of SDQ. Sleep 1994;17:160-7.
36. Gersuk VH, Nepom GT. A real-time PCR approach for rapid high resolution subtyping of HLA-DRB1*04. J Immunol Methods 2006;317:64-70.
37. Gersuk VH, Nepom GT. A real-time polymerase chain reaction assay for the rapid identification of the autoimmune disease-associated allele HLA-DQB1*0602. Tissue Antigens 2009;73:335-40.
38. Armitage P, Berry G. Statistical methods in medical research. 3rd ed. London: Blackwell Science, 1994.
39. Mignot E, Young T, Lin L, Finn L. Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB 1*0602. Sleep 1999;22:347-52.
40. Hong SC, Hayduk R, Lim J, Mignot E. Clinical and polysomnographic features in DQB1 *0602 positive and negative narcolepsy patients: results from the modafinil clinical trial. Sleep Med 2000;1:33-9.
41. Sasai T, Inoue Y, Komada Y, Sugiura T, Matsushima E. Comparison of clinical characteristics among narcolepsy with and without cataplexy and idiopathic hypersomnia without long sleep time, focusing on HLADRB1(*) 1501/DQB1(*)0602 finding. Sleep Med 2009;10:961-6.
42. Scammell TE. The frustrating and mostly fruitless search for an autoimmune cause of narcolepsy. Sleep 2006;29:601-2.
43. Aran A, Lin L, Nevsimalova S, et al. Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep 2009;32:979-83.
44. Kotb M, Norrby-Teglund A, McGeer A, et al. An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med 2002;8:1398-404.
45. Stanevicha V, Eglite J, Zavadska D, Sochnevs A, Shantere R, Gardovska D. HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children. Arthritis Res Ther 2007;9:R58.
46. Matsuki K, Honda Y, Juji T. Diagnostic criteria for narcolepsy and HLA-DR2 frequencies. Tissue Antigens 1987;30:155-60.
47. Mignot E. Genetic and familial aspects of narcolepsy. Neurology 1998;50:S16-22.
48. Mignot E, Hayduk R, Black J, Grumet FC, GuiUeminault C. HLA DQB 1*0602 is associated with cataplexy in 509 narcoleptic patients. Sleep 1997;20:1012-20.