AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity

Journal of Neurochemistry

Volumn 112, Issue 4, 2010, Pages 991-1004

  McKee, Alex G ^a   Loscher, Jennifer S ^b   O'Sullivan, Niamh C ^b   Chadderton, Naomi ^a   Palfi, Arpad ^a   Batti, Laura ^b   Sheridan, Graham K ^b   O'Shea, Sean ^b   Moran, Mary ^b   McCabe, Olive ^b   Fernández, Alfonso Blanco ^b   Pangalos, Menelas N ^c   O'Connor, John J ^b   Regan, Ciaran M ^b   O'Connor, William T ^b   Humphries, Peter ^a   Farrar, G Jane ^a   Murphy, Keith J ^b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c PFIZER INC   (United States)

Author keywords

Adenoassociated virus mediated gene delivery; Fear conditioning; Paired pulse facilitation; Synaptic vesicle release; Synaptosomal protein of 25 kDa; Water maze

Indexed keywords

GLUTAMIC ACID; PARVOVIRUS VECTOR; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25;

ADENO ASSOCIATED VIRUS; ANIMAL TISSUE; ARTICLE; CELL LEVEL; COGNITIVE DEFECT; CONDITIONING; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; FACILITATION; FEAR; GENE ACTIVITY; GENE OVEREXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN CELL; LONG TERM MEMORY; MAZE TEST; MEMORY CONSOLIDATION; MICRODIALYSIS; NERVE CELL PLASTICITY; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION; VIRUS RECOMBINANT;

ANIMALS; AVOIDANCE LEARNING; BIOPHYSICS; CELL LINE, TRANSFORMED; CONDITIONING, CLASSICAL; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EXPLORATORY BEHAVIOR; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GLUTAMIC ACID; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; HUMANS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICRODIALYSIS; NEURAL INHIBITION; NEURONAL PLASTICITY; RATS; RATS, WISTAR; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; TRANSDUCTION, GENETIC; TRANSFECTION;

RATTUS;

EID: 75149181068     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06516.x     Document Type: Article

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