Adeno-associated virus transfer of a gene encoding SNAP-25 resistant to botulinum toxin A attenuates neuromuscular paralysis associated with botulism

Journal of Neuroscience

Volumn 28, Issue 14, 2008, Pages 3683-3688

  Raghunath, Arvind ^a   Perez Branguli, Francesc ^a   Smith, Leonard ^b   Dolly, J Oliver ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

Botulinum; Gene transfer; Motor neuron; Neuromuscular junction; SNARE proteins; Sprouting

Indexed keywords

ACETYLCHOLINE; BOTULINUM TOXIN A; CATECHOLAMINE; PARVOVIRUS VECTOR; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; GREEN FLUORESCENT PROTEIN; MUSCLE RELAXANT AGENT; SERINE; THREONINE;

ACETYLCHOLINE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOTULISM; CATECHOLAMINE RELEASE; CHROMAFFIN CELL; CONTROLLED STUDY; EXOCYTOSIS; FATALITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE SPROUTING; NEUROMUSCULAR TRANSMISSION; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; RAT; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; ADENO ASSOCIATED VIRUS; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENDOCYTOSIS; GENE TRANSFER; GENETICS; METABOLISM; MUTATION; NEUROMUSCULAR SYNAPSE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSEUDOBULBAR PALSY; SKELETAL MUSCLE;

ANIMALS; BOTULINUM TOXIN TYPE A; BOTULISM; CATECHOLAMINES; CELLS, CULTURED; CHROMAFFIN CELLS; DEPENDOVIRUS; ENDOCYTOSIS; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; MUSCLE, SKELETAL; MUTATION; NEUROMUSCULAR AGENTS; NEUROMUSCULAR JUNCTION; PSEUDOBULBAR PALSY; RATS; SERINE; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; THREONINE;

EID: 43649095758     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5690-07.2008     Document Type: Article

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