Akt interaction with PLCγ regulates the G2/M transition triggered by FGF receptors from MDA-MB-231 breast cancer cells

Anticancer Research

Volumn 29, Issue 12, 2009, Pages 4965-4969

  Browaeys Poly, Edith ^a   Perdereau, Dominique ^b,c   Lescuyer, Arlette ^a   Burnol, Anne Françoise ^b,c   Cailliau, Katia ^a  

^a UNIV LILLE   (France)

^b INSTITUT COCHIN   (France)

^c INSERM   (France)

Author keywords

Akt; Breast cancer; Chfr; Fibroblast growth factor receptor; MDA MB 231; PLC ; Xenopus oocyte

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR; PHOSPHOLIPASE C GAMMA; PROTEIN CHFR; PROTEIN KINASE B; PROTEIN SH3; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME BINDING; ENZYME PHOSPHORYLATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

ANIMALS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL DIVISION; ELECTROPHYSIOLOGY; FEMALE; FIBROBLAST GROWTH FACTOR 1; G2 PHASE; HUMANS; IMMUNOPRECIPITATION; MICROINJECTIONS; OOCYTES; PHOSPHOLIPASE C GAMMA; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, FIBROBLAST GROWTH FACTOR; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

EID: 75149180919     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Dillon C, Spencer-Dene B and Dickson C: A crucial role for fibroblast growth factor signaling in embryonic mammary gland development. J Mammary Gland Biol Neoplasia 9: 207-215, 2004.
2. Anandappa SY, Winstanley JH, Leinster S, Green B, Rudland PS and Barraclough R: Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease. Br J Cancer 69: 772-776, 1994.
3. Yoshimura N, Sano H, Hashiramoto A, Yamada R, Nakajima H, Kondo M and Oka T: The expression and localization of fibroblast growth factor-1 (FGF-I) and FGF receptor-1 (FGFR-1) in human breast cancer. Clin Immunol Immunopathol 89: 28-34, 1998.
4. Eswarakumar VP, Lax I and Schlessinger J: Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev 16: 139-149, 2005.
5. Penault-Llorca F, Bertucci F, Adelaide J, Pare P, Coulier F, Jacquemier J, Birnbaum D and deLapeyriere O: Expression of FGF and FGF receptor genes in human breast cancer. Int J Cancer 61: 170-176, 1995.
6. Klint P and Claesson-Welsh L: Signal transduction by fibroblast growth factor receptors. Front Biosci 4: D165-177, 1999.
7. Piccolo E, Innominato PF, Mariggio MA, Maffucci T, Iacobelli S and Falasca M: The mechanism involved in the regulation of phospholipase Cγl activity in cell migration. Oncogene 21: 6520-6529, 2002.
8. Nicholson KM and Anderson NG: The protein kinase B/Akt signaling pathway in human malignancy. Cell Signal 14: 381-395, 2002.
9. Lu Y, Wang H and Mills GB: Targeting PI3K-AKT pathway for cancer therapy. Rev Clin Exp Hematol 7: 205-228, 2003.
10. Mills GB, Kohn E, Lu Y, Eder A, Fang X, Wang H, Bast RC, Gray J, Jaffe R and Hortobagyi G: Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer. Semin Oncol 30: 93-104, 2003.
11. Shepard CR, Kassis J, Whaley DL, Kim HG and Wells A: PLCγ contributes to metastasis of in situ-occurring mammary and prostate tumors. Oncogene 26: 3020-3026, 2007.
12. Liang K, Jin W, Knuefermann C, Schmidt M, Mills GB, Ang KK, Milas L and Fan Z: Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy. Mol Cancer Ther 2: 353-360, 2003.
13. Albert JM, Kim KW, Cao C and Lu B: Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer. Mol Cancer Ther 5: 1183-1189, 2006.
14. Wang Y, Wu J and Wang Z: Akt binds to and phosphorylates phospholipase C-γl in response to epidermal growth factor. Mol Biol Cell 17: 2267-2277, 2006.
15. 2/M checkpoint defects in breast cancer cells. Mol Carcinog 39: 26-33, 2004.
16. Privette LM, González ME, Ding L, Kleer CG and Petty EM: Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression. Cancer Res 67: 6064-6074, 2007.
17. Shtivelman E: Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR. Mol Cancer Res 1: 959-969, 2003.
18. Kang D, Wong J and Fang G: A Xenopus cell-free system for analysis of the Chfr ubiquitin ligase involved in control of mitotic entry. Methods Mol Biol 280: 229-243, 2004.
19. Ferrell JE: Xenopus oocyte maturation: new lessons from a good egg. Bioassays 21: 833-842, 1999.
20. Cailliau K, Perdereau D, Lescuyer A, Chen H, Garbay C, Vilain JP, Burnol AF and Browaeys-Poly E: FGF receptor phosphotyrosine 766 is a target for Grbl4 to inhibit MDA-MB-231 human breast cancer cell signaling. Anticancer Res 25: 3877-3882, 2005.
21. Browaeys-Poly E, Cailliau K and Vilain JP: Signal transduction pathways triggered by fibroblast growth factor receptor 1 expressed in Xenopus laevis oocytes after fibroblast growth factor 1 addition. Role of Grb2, phosphatidylinositol 3-kinase, Src tyrosine kinase, and phospholipase Cγ. Eur J Biochem 267: 6256-6263, 2000.
22. Goenaga D, Hampe C, Carré N, Cailliau K, Browaeys-Poly E, Perdereau D, Holt LJ, Daly RJ, Girard J, Broutin I, Issad T and Burnol AF: Molecular determinants of Grbl4-mediated inhibition of insulin signaling. Mol Endocrinol 23: 1043-1051, 2009.
23. Browaeys-Poly E, Cailliau K and Vilain JP: Transduction cascades initiated by fibroblast growth factor 1 on Xenopus oocytes expressing MDA-MB-231 mRNAs. Role of Grb2, phosphatidylinositol 3-kinase, Src tyrosine kinase, and phospholipase Cγ. Cell Signal 13: 363-368, 2001.
24. Browaeys-Poly E, Cailliau K and Vilain JP: Fibroblast and epidermal growth factor receptor expression in Xenopus oocytes displays distinct calcium oscillatory patterns. Biochim Biophys Acta 1404: 484-489, 1998.
25. Kandel ES and Hay N: The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 253: 210-229, 1999.