FGF receptor phosphotyrosine 766 is a target for Grb14 to inhibit MDA-MB-231 human breast cancer cell signaling

Anticancer Research

Volumn 25, Issue 6 B, 2005, Pages 3877-3882

  Cailliau, Katia ^a   Perdereau, Dominique ^b   Lescuyer, Arlette ^a   Chen, Huixiong ^c   Garbay, Christiane ^c   Vilain, Jean Pierre ^a   Burnol, Anne Françoise ^b   Browaeys Poly, Edith ^a  

^a UNIV LILLE   (France)

^b INSTITUT COCHIN   (France)

^c CNRS   (France)

Author keywords

Breast cancer; Fibroblast growth factor receptor; Grb14; MDA MB 231; Xenopus oocyte

Indexed keywords

ADAPTOR PROTEIN; FIBROBLAST GROWTH FACTOR RECEPTOR; HYBRID PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHOLIPASE C GAMMA; PHOSPHOPEPTIDE; PROTEIN GRB14; PROTEIN KINASE B; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MICROINJECTION; OOCYTE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; XENOPUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLAST GROWTH FACTOR 1; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 8; ONCOGENE PROTEIN V-AKT; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEINS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SIGNAL TRANSDUCTION; TRANSDUCTION, GENETIC; XENOPUS LAEVIS;

EID: 27944491472     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Dillon C, Spencer-Dene B and Dickson C: A crucial role for fibroblast growth factor signaling in embryonic mammary gland development. J Mammary Gland Biol Neoplasia 9: 207-215, 2004.
2. Anandappa SY, Winstanley JH, Leinster S, Green B, Rudland PS and Barraclough R: Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease. Br J Cancer 69: 772-776, 1994.
3. Relf M, LeJeune S, Scott PA, Fox S, Smith K, Leek R, Moghaddam A, Whitehouse R, Bicknell R and Harris AL: Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 57: 963-969, 1997.
4. Yoshimura N, Sano H, Hashiramoto A, Yamada R, Nakajima H, Kondo M and Oka T: The expression and localization of fibroblast growth factor-1 (FGF-1) and FGF receptor-1 (FGFR-1) in human breast cancer. Clin Immunol Immunopathol 89: 28-34, 1998.
5. Renaud F, El Yazidi I, Boilly-Marer Y, Courtois Y and Laurent M: Expression and regulation by serum of multiple FGF1 mRNA in normal transformed, and malignant human mammary epithelial cells. Biochem Biophys Res Commun 219: 679-685, 1996.
6. Fernig DG, Chen HL, Rahmoune H, Descamps S, Boilly B and Hondermarck H: Differential regulation of FGF-1 and -2 mitogenic activity is related to their kinetics of binding to heparan sulfate in MDA-MB-231 human breast cancer cells. Biochem Biophys Res Commun 267: 770-776, 2000.
7. Nurcombe V, Smart CE, Chipperfield H, Cool SM, Boilly B and Hondermarck H: The proliferative and migratory activities of breast cancer cells can be differentially regulated by heparan sulfates. J Biol Chem 275: 30009-30018, 2000.
8. Penault-Llorca F, Bertucci F, Adelaide J, Pare P, Coulier F, Jacquemier J, Birnbaum D and deLapeyriere O: Expression of FGF and FGF receptor genes in human breast cancer. Int J Cancer 61: 170-176, 1995.
9. Klint P and Claesson-Welsh L: Signal transduction by fibroblast growth factor receptors. Front Biosci 4: D165-177, 1999.
10. Mohammadi M, Dionne CA, Li W, Li N, Spivak T, Honegger AM, Jaye M and Schlessinger J: Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature 358: 681-684, 1992.
11. Ong SH, Hadari YR, Gotoh N, Guy GR, Schlessinger J and Lax I: Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci USA 98: 6074-6079, 2001.
12. Piccolo E, Innominato PF, Mariggio MA, Maffucci T, Iacobelli S and Falasca M: The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration. Oncogene 21: 6520-6529, 2002.
13. Daly RJ: The Grb7 family of signalling proteins. Cell Signal 10: 613-618, 1998.
14. Cariou B, Bereziat V, Moncoq K, Kasus-Jacobi A, Perdereau D, Le Marcis V and Burnol AF: Regulation and functional roles of Grb14. Front Biosci 9: 1626-1636, 2004.
15. Reilly JF, Mickey G and Maher PA: Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner. J Biol Chem 275: 7771-7778, 2000.
16. Cailliau K, Le Marcis V, Bereziat V, Perdereau D, Cariou B, Vilain JP, Burnol AF and Browaeys-Poly E: Inhibition of FGF receptor signalling in Xenopus oocytes: differential effect of Grb7, Grb10 and Grb14. FEBS Lett 548: 43-48, 2003.
17. Bereziat V, Kasus-Jacobi A, Perdereau D, Cariou B, Girard J and Burnol AF: Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14. J Biol Chem 277: 4845-4852, 2002.
18. Kasus-Jacobi A, Perdereau D, Auzan C, Clauser E, Van Obberghen E, Mauvais-Jarvis F, Girard J and Burnol AF: Identification of the rat adapter Grb14 as an inhibitor of insulin actions. J Biol Chem 273: 26026-26135, 1998.
19. Kairouz R, Parmar J, Lyons RJ, Swarbrick A, Musgrove EA and Daly RJ: Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells. J Cell Physiol 203: 85-93, 2005.
20. Browaeys-Poly E, Cailliau K and Vilain JP: Transduction cascades initiated by fibroblast growth factor 1 on Xenopus oocytes expressing MDA-MB-231 mRNAs. Role of Grb2, phosphatidylinositol 3-kinase, Src tyrosine kinase, and phospholipase Cgamma. Cell Signal 13: 363-368, 2001.
21. Chuang LM, Hausdorff SF, Myers MG Jr, White MF, Birnbaum MJ and Kahn CR: Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes. J Biol Chem 269: 27645-27649, 1994.
22. Browaeys-Poly E, Cailliau K and Vilain JP: Signal transduction pathways triggered by fibroblast growth factor receptor 1 expressed in Xenopus laevis oocytes after fibroblast growth factor 1 addition. Role of Grb2, phosphatidylinositol 3-kinase, Src tyrosine kinase, and phospholipase C gamma. Eur J Biochem 267: 6256-6263, 2000.
23. Dunican DJ, Williams EJ, Howell FV and Doherty P: Selective inhibition of fibroblast growth factor (FGF)-stimulated mitogenesis by a FGF receptor-1-derived phosphopeptide. Cell Growth Differ 12: 255-264, 2001.
24. Aroca P, Mahadevan D and Santos E: Functional interactions between isolated SH2 domains and insulin/Ras signaling pathways of Xenopus oocytes: opposite effects of the carboxy-and amino-terminal SH2 domains of p85 PI 3-kinase. Oncogene 13: 1839-1846, 1996.
25. Poulin B, Sekiya F and Rhee SG: Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-(gamma)1. Proc Natl Acad Sci USA 102: 4276-4281, 2005.
26. Browaeys-Poly E, Fafeur V, Vilain JP and Cailliau K: ERK2 is required for FGF1-induced JNK1 phosphorylation in Xenopus oocyte expressing FGF receptor 1. Biochim Biophys Acta 1743: 1-4, 2005.
27. Price JT, Tiganis T, Agarwal A, Djakiew D and Thompson EW: Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism. Cancer Res 59: 5475-5478, 1999.
28. Seddighzadeh M, Zhou JN, Kronenwett U, Shoshan MC, Auer G, Sten-Linder M, Wiman B and Linder S: ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation. Clin Exp Metastasis 17: 649-654, 1999.
29. Krueger JS, Keshamouni VG, Atanaskova N and Reddy KB: Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion. Oncogene 20: 4209-4218, 2001.
30. Mingo-Sion AM, Marietta PM, Koller E, Wolf DM and Van Den Berg CL: Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells. Oncogene 23: 596-604, 2004.
31. Daly JM, Olayioye MA, Wong AM, Neve R, Lane HA, Maurer FG and Hynes NE: NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways. Oncogene 18: 3440-3451, 1999.