메뉴 건너뛰기




Volumn 15, Issue 12, 2009, Pages

Ticagrelor - A new platelet aggregation inhibitor in patients with acute coronary syndromes. An improvement of other inhibitors?

Author keywords

Acute coronary syndrome; Clopidpgrel; P2Y12 receptor; Thienopyridines; Ticagrelor

Indexed keywords

3A,4,4A,5,6,7,8,8A,9,9A DECAHYDRO N [4 [2 [5 (3 FLUOROPHENYL) 2 PYRIDYL]VINYL] 3 METHYL 1 OXO 3H BENZO[F]ISOBENZOFURAN 7 YL]CARBAMIC ACID ETHYL ESTER; ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CANGRELOR; CLOPIDOGREL; PLACEBO; PRASUGREL; THIENOPYRIDINE DERIVATIVE; THROMBIN INHIBITOR; TICAGRELOR; TISSUE PLASMINOGEN ACTIVATOR;

EID: 75149174409     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (35)

References (60)
  • 1
    • 0030590746 scopus 로고    scopus 로고
    • A randomized blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee
    • CAPRIE Steering Committee: A randomized blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet, 1996; 348: 1329-39
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 2
    • 0035908781 scopus 로고    scopus 로고
    • Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCICURE study
    • Mehta SR, Yusuf S, Peters RJ et al: Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCICURE study. Lancet, 2001; 358: 527-33
    • (2001) Lancet , vol.358 , pp. 527-533
    • Mehta, S.R.1    Yusuf, S.2    Peters, R.J.3
  • 3
    • 0035899289 scopus 로고    scopus 로고
    • Clopidogrel in unstable angina to prevent recurrent events trial investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without STsegment elevation
    • Yusuf S, Zhao F, Mehta SR et al: Clopidogrel in unstable angina to prevent recurrent events trial investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without STsegment elevation. N Engl J Med, 2001; 345: 494-502
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3
  • 4
    • 0037145863 scopus 로고    scopus 로고
    • CREDO Investigators. Clopidogrel for the Reduction of Events During Observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention. A randomized controlled trial
    • Steinhubl SR, Berger PB, Mann JT III et al: CREDO Investigators. Clopidogrel for the Reduction of Events During Observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention. A randomized controlled trial. JAMA, 2002; 288: 2411-20
    • (2002) JAMA , vol.288 , pp. 2411-2420
    • Steinhubl, S.R.1    Berger, P.B.2    Mann III, J.T.3
  • 5
    • 27644548513 scopus 로고    scopus 로고
    • COMMIT (ClOpidogrel and Metoprolol in Myocardial Infarction Trial) collaborative group. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: Randomised, placebo-controlled trial
    • Chen ZM, Jiang LX, Chen YP et al: COMMIT (ClOpidogrel and Metoprolol in Myocardial Infarction Trial) collaborative group. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised, placebo-controlled trial. Lancet, 2005; 366: 1607-21
    • (2005) Lancet , vol.366 , pp. 1607-1621
    • Chen, Z.M.1    Jiang, L.X.2    Chen, Y.P.3
  • 6
    • 24644495673 scopus 로고    scopus 로고
    • Clopidogrel as Adjunctive Reperfusion Therapy (CLARITY)-Thrombolysis in Myocardial Infarction (TIMI) 28 Investigators. Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: The PCI-CLARITY study
    • Sabatine MS, Cannon CP, Gibson CM et al: Clopidogrel as Adjunctive Reperfusion Therapy (CLARITY)-Thrombolysis in Myocardial Infarction (TIMI) 28 Investigators. Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: the PCI-CLARITY study. JAMA, 2005; 294: 1224-32
    • (2005) JAMA , vol.294 , pp. 1224-1232
    • Sabatine, M.S.1    Cannon, C.P.2    Gibson, C.M.3
  • 7
    • 38349121677 scopus 로고    scopus 로고
    • Functional effects of high clopidogrel maintenance dosing in patients with inadequate platelet inhibition on standard dose treatment
    • Angiolillo DJ, Costa MA, Shoemaker SB et al: Functional effects of high clopidogrel maintenance dosing in patients with inadequate platelet inhibition on standard dose treatment. Am J Cardiol, 2008; 101: 440-45
    • (2008) Am J Cardiol , vol.101 , pp. 440-445
    • Angiolillo, D.J.1    Costa, M.A.2    Shoemaker, S.B.3
  • 8
    • 38349137324 scopus 로고    scopus 로고
    • Functional impact of high clopidogrel maintenance dosing in patients undergoing elective percutaneous coronary interventions. Results of a randomized study
    • Angiolillo DJ, Bernardo E, Palazuelos J et al: Functional impact of high clopidogrel maintenance dosing in patients undergoing elective percutaneous coronary interventions. Results of a randomized study. Thromb Haemost, 2008; 99: 161-68
    • (2008) Thromb Haemost , vol.99 , pp. 161-168
    • Angiolillo, D.J.1    Bernardo, E.2    Palazuelos, J.3
  • 9
    • 70449589009 scopus 로고    scopus 로고
    • Significance of mean platelet volume on prognosis of patients with and without aspirin resistance in settings of non-ST-segment elevated acute coronary syndromes
    • in press
    • Ozer O, Unal Aksu H, Hobikoglu G et al: Significance of mean platelet volume on prognosis of patients with and without aspirin resistance in settings of non-ST-segment elevated acute coronary syndromes. Blood Coagul Fibrinolysis, 2009; (in press)
    • (2009) Blood Coagul Fibrinolysis
    • Ozer, O.1    Unal Aksu, H.2    Hobikoglu, G.3
  • 10
    • 66949176667 scopus 로고    scopus 로고
    • Dual antiplatelet drug resistance in patients with acute coronary syndrome
    • Guha S, Sardar P, Guha P et al: Dual antiplatelet drug resistance in patients with acute coronary syndrome. Indian Heart J, 2009; 61: 68-73
    • (2009) Indian Heart J , vol.61 , pp. 68-73
    • Guha, S.1    Sardar, P.2    Guha, P.3
  • 11
    • 70649084103 scopus 로고    scopus 로고
    • Aspirin resistance: Current evidence and clinical implications
    • in press
    • Kasotakis G, Pipinos II, Lynch TG: Aspirin resistance: Current evidence and clinical implications. J Vasc Surg, 2009; (in press)
    • (2009) J Vasc Surg
    • Kasotakis, G.1    Pipinos, I.I.2    Lynch, T.G.3
  • 12
    • 37849002889 scopus 로고    scopus 로고
    • Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirintreated patients with coronary artery disease
    • Lars W, Varenhorst C, James S et al: Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirintreated patients with coronary artery disease. Eur Heart J, 2008; 29: 21-30
    • (2008) Eur Heart J , vol.29 , pp. 21-30
    • Lars, W.1    Varenhorst, C.2    James, S.3
  • 13
    • 34249053105 scopus 로고    scopus 로고
    • The disposition of prasugrel, a novel thienopyridine, in humans
    • Farid NA, Smith RL, Gillespie TA et al: The disposition of prasugrel, a novel thienopyridine, in humans. Drug Metab Dispos, 2007; 35: 1096-104
    • (2007) Drug Metab Dispos , vol.35 , pp. 1096-1104
    • Farid, N.A.1    Smith, R.L.2    Gillespie, T.A.3
  • 14
    • 75149129009 scopus 로고    scopus 로고
    • Platelet-Michelson AD ed, San Diego, CA: Academic Press
    • Cattaneo M: ADP receptors antagonists. In: Platelet-Michelson AD (ed.), San Diego, CA: Academic Press, 2006: 1127-44
    • (2006) ADP receptors antagonists , pp. 1127-1144
    • Cattaneo, M.1
  • 15
    • 36148983750 scopus 로고    scopus 로고
    • TRITON TIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • Wiviott SD, Braunwald E, McCabe CH et al: TRITON TIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl Med, 2007; 357: 2001-15
    • (2007) N Engl Med , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 16
    • 33748495552 scopus 로고    scopus 로고
    • Protease-activated receptors in cardiovascular diseases
    • Leger AJ, Covic L, Kuliopulos A: Protease-activated receptors in cardiovascular diseases. Circulation, 2006; 114: 1070-77
    • (2006) Circulation , vol.114 , pp. 1070-1077
    • Leger, A.J.1    Covic, L.2    Kuliopulos, A.3
  • 17
    • 33748523149 scopus 로고    scopus 로고
    • Thrombin receptor (protease activated receptor-1) antagonists as potent antithrombotic agents with strong antiplatelet effects
    • Chackalamannil S: Thrombin receptor (protease activated receptor-1) antagonists as potent antithrombotic agents with strong antiplatelet effects. J Med Chem, 2006; 49: 5389-403
    • (2006) J Med Chem , vol.49 , pp. 5389-5403
    • Chackalamannil, S.1
  • 18
    • 24944580749 scopus 로고    scopus 로고
    • Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents
    • Chackalamannil S, Xia Y, Greenlee WJ et al: Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents. J Med Chem, 2005; 48: 5884-87
    • (2005) J Med Chem , vol.48 , pp. 5884-5887
    • Chackalamannil, S.1    Xia, Y.2    Greenlee, W.J.3
  • 19
    • 68949156886 scopus 로고    scopus 로고
    • TRA 2(o)P-TIMI 50 Investigators. Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial
    • Morrow DA, Scirica BM, Fox KA et al: TRA 2(o)P-TIMI 50 Investigators. Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial. Am Heart J, 2009; 158: 335-41
    • (2009) Am Heart J , vol.158 , pp. 335-341
    • Morrow, D.A.1    Scirica, B.M.2    Fox, K.A.3
  • 20
    • 67949091145 scopus 로고    scopus 로고
    • New P2Y12 blockers
    • Cattaneo M: New P2Y12 blockers. J Thromb Haemost, 2009; 7: 262-65
    • (2009) J Thromb Haemost , vol.7 , pp. 262-265
    • Cattaneo, M.1
  • 21
    • 18044388905 scopus 로고    scopus 로고
    • Preclinical and clinical studies with selective reversible direct P2Y12 antagonists
    • van Giezen JJJ, Humphries RG: Preclinical and clinical studies with selective reversible direct P2Y12 antagonists. Semin Thromb Hemost, 2005; 31: 195-204
    • (2005) Semin Thromb Hemost , vol.31 , pp. 195-204
    • van Giezen, J.J.J.1    Humphries, R.G.2
  • 22
    • 0033781969 scopus 로고    scopus 로고
    • Lucchesi. Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model
    • Huang J, Driscoll EM, Gonzales ML et al: Lucchesi. Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model. J Pharmacol Exp Ther, 2000; 295: 492-99
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 492-499
    • Huang, J.1    Driscoll, E.M.2    Gonzales, M.L.3
  • 23
    • 0004979894 scopus 로고    scopus 로고
    • Effect of the novel P2T receptor antagonist, AR-C69931MX, on thrombosis and hemostasis in the dog: Comparison with GPIIb/IIIa antagonists
    • Humphries RG, Tomlinson W, Ingall AH et al: Effect of the novel P2T receptor antagonist, AR-C69931MX, on thrombosis and hemostasis in the dog: comparison with GPIIb/IIIa antagonists. Haematologica, 2000; 85: 91-92
    • (2000) Haematologica , vol.85 , pp. 91-92
    • Humphries, R.G.1    Tomlinson, W.2    Ingall, A.H.3
  • 24
    • 0037341392 scopus 로고    scopus 로고
    • In vivo blockade of platelet ADP receptor P2Y12 reduces embolus and thrombus formation but not thrombus stability
    • van Gestel MA, Heemskerk JW, Slaaf DW et al: In vivo blockade of platelet ADP receptor P2Y12 reduces embolus and thrombus formation but not thrombus stability. Arterioscler Thromb Vasc Biol, 2003; 23: 518-23
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 518-523
    • van Gestel, M.A.1    Heemskerk, J.W.2    Slaaf, D.W.3
  • 25
    • 0037289827 scopus 로고    scopus 로고
    • Blockade of the platelet P2Y12 receptor by AR-C69931MX sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model
    • Wang K, Zhou X, Zhou Z et al: Blockade of the platelet P2Y12 receptor by AR-C69931MX sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model. Arterioscler Thromb Vasc Biol, 2003; 23: 357-62
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 357-362
    • Wang, K.1    Zhou, X.2    Zhou, Z.3
  • 26
    • 33344464928 scopus 로고    scopus 로고
    • Initial experience with an intravenous P2Y12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: Results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial
    • Greenbaum AB, Grines CL, Bittl JA et al: Initial experience with an intravenous P2Y12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial. Am Heart J, 2006; 151: 689
    • (2006) Am Heart J , vol.151 , pp. 689
    • Greenbaum, A.B.1    Grines, C.L.2    Bittl, J.A.3
  • 27
    • 34548849756 scopus 로고    scopus 로고
    • Preliminary experience with intravenous P2Y12 platelet receptor inhibition as an adjunct to reduced-dose alteplase during acute myocardial infarction: Results of the Safety, Tolerability and Effect on Patency in Acute Myocardial Infarction STEP-AMI) angiographic trial
    • Greenbaum AB, Ohman EM, Gibson CM et al: Preliminary experience with intravenous P2Y12 platelet receptor inhibition as an adjunct to reduced-dose alteplase during acute myocardial infarction: results of the Safety, Tolerability and Effect on Patency in Acute Myocardial Infarction STEP-AMI) angiographic trial. Am Heart J, 2007; 154: 702-9
    • (2007) Am Heart J , vol.154 , pp. 702-709
    • Greenbaum, A.B.1    Ohman, E.M.2    Gibson, C.M.3
  • 28
    • 75149178032 scopus 로고    scopus 로고
    • Medicines Company: The Medicines Company discontinues phase 3 CHAMPION clinical trial program of cangrelor [press release]. May 13, 2009
    • Medicines Company: The Medicines Company discontinues phase 3 CHAMPION clinical trial program of cangrelor [press release]. May 13, 2009
  • 29
    • 75149180444 scopus 로고    scopus 로고
    • Maintenance of Platelet Inhibition With Cangrelor BRIDGE Study
    • Maintenance of Platelet Inhibition With Cangrelor (BRIDGE Study). http://clinicaltrials.gov/ct2/show/NCT00767507
  • 30
    • 37249068049 scopus 로고    scopus 로고
    • Platelet activation and atherothrombosis
    • Davi G, Patrono C: Platelet activation and atherothrombosis. N Engl J Med, 2007; 357: 2482-94
    • (2007) N Engl J Med , vol.357 , pp. 2482-2494
    • Davi, G.1    Patrono, C.2
  • 31
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • Hollopeter G, Jantzen HM, Vincent D et al: Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature, 2001; 409: 145-47
    • (2001) Nature , vol.409 , pp. 145-147
    • Hollopeter, G.1    Jantzen, H.M.2    Vincent, D.3
  • 32
    • 5344257562 scopus 로고    scopus 로고
    • ADP Receptor P2Y12 Is Expressed in Vascular Smooth Muscle Cells and Stimulates Contraction in Human Blood Vessels
    • Wihlborg AK, Wang L, Braun OO et al: ADP Receptor P2Y12 Is Expressed in Vascular Smooth Muscle Cells and Stimulates Contraction in Human Blood Vessels Thromb Vasc Biol, 2004; 24: 1810-15
    • (2004) Thromb Vasc Biol , vol.24 , pp. 1810-1815
    • Wihlborg, A.K.1    Wang, L.2    Braun, O.O.3
  • 33
    • 33748559416 scopus 로고    scopus 로고
    • Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors
    • Mamedova LK, Gao ZG, Jacobson KA: Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors. Biochem Pharmacol, 2006; 72: 1031
    • (2006) Biochem Pharmacol , vol.72 , pp. 1031
    • Mamedova, L.K.1    Gao, Z.G.2    Jacobson, K.A.3
  • 34
    • 0344200064 scopus 로고    scopus 로고
    • Role of intracellular signalling events in ADP-induced platelet aggregation
    • Daniel JL, Dangelmaier C, Jin J et al: Role of intracellular signalling events in ADP-induced platelet aggregation. Thromb Haemost, 1999; 82: 1322-26
    • (1999) Thromb Haemost , vol.82 , pp. 1322-1326
    • Daniel, J.L.1    Dangelmaier, C.2    Jin, J.3
  • 35
    • 0032828089 scopus 로고    scopus 로고
    • Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors
    • Paul BZ, Jin J, Kunapuli SP: Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors. J Biol Chem, 1999; 274: 29108-14
    • (1999) J Biol Chem , vol.274 , pp. 29108-29114
    • Paul, B.Z.1    Jin, J.2    Kunapuli, S.P.3
  • 36
    • 0031914973 scopus 로고    scopus 로고
    • Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets
    • Daniel JL, Dangelmaier C, Jin J et al: Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets. J Biol Chem, 1998; 273: 2024-29
    • (1998) J Biol Chem , vol.273 , pp. 2024-2029
    • Daniel, J.L.1    Dangelmaier, C.2    Jin, J.3
  • 37
    • 0031916728 scopus 로고    scopus 로고
    • Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets
    • Jin J, Daniel JL, Kunapuli SP: Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J Biol Chem, 1998; 273: 2030-34
    • (1998) J Biol Chem , vol.273 , pp. 2030-2034
    • Jin, J.1    Daniel, J.L.2    Kunapuli, S.P.3
  • 38
    • 35548933800 scopus 로고    scopus 로고
    • Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes
    • Storey RF, Husted S, Harrington RA et al: Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes. J Am Coll Cardiol, 2007; 50: 1852-56
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1852-1856
    • Storey, R.F.1    Husted, S.2    Harrington, R.A.3
  • 39
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, Emanuelsson H, Heptinstall S et al: Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur Heart J, 2006; 27: 1038-47
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3
  • 40
    • 33846817108 scopus 로고    scopus 로고
    • Tantry US, Bliden KP, Gurbel PA: AZD6140. Expert Opin Investig Drugs, 2007; 16: 225-29
    • Tantry US, Bliden KP, Gurbel PA: AZD6140. Expert Opin Investig Drugs, 2007; 16: 225-29
  • 41
    • 0042859862 scopus 로고    scopus 로고
    • Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects
    • Fontana P, Dupont A, Gandrille S et al: Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. Circulation, 2003; 108: 989-95
    • (2003) Circulation , vol.108 , pp. 989-995
    • Fontana, P.1    Dupont, A.2    Gandrille, S.3
  • 42
    • 11144232964 scopus 로고    scopus 로고
    • Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP
    • Hetherington SL, Singh RK, Lodwick D et al: Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP. Arterioscler Thromb Vasc Biol, 2005; 25: 252-57
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 252-257
    • Hetherington, S.L.1    Singh, R.K.2    Lodwick, D.3
  • 43
    • 0346365089 scopus 로고    scopus 로고
    • P2Y12 H2 haplotype is associated with peripheral arterial disease: A case-control study
    • Fontana P, Gaussem P, Aiach M et al: P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study. Circulation, 2003; 108: 2971-73
    • (2003) Circulation , vol.108 , pp. 2971-2973
    • Fontana, P.1    Gaussem, P.2    Aiach, M.3
  • 44
    • 68949130179 scopus 로고    scopus 로고
    • P2Y12 inhibitors: Differences in properties and mechanisms of action and potential consequences for clinical use
    • Lars W: P2Y12 inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use. Eur Heart J, 2009; 30: 1964-77
    • (2009) Eur Heart J , vol.30 , pp. 1964-1977
    • Lars, W.1
  • 45
    • 62949141274 scopus 로고    scopus 로고
    • Comparison of ticagrelor, the first reversible oral P2Y12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial
    • James S, Akerblom A, Cannon CP et al: Comparison of ticagrelor, the first reversible oral P2Y12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J, 2009; 157: 599-605
    • (2009) Am Heart J , vol.157 , pp. 599-605
    • James, S.1    Akerblom, A.2    Cannon, C.P.3
  • 46
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes
    • for the PLATO investigators
    • Wallentin L, Becker RC, Budaj A et al for the PLATO investigators: Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes. N Engl J Med, 2009; 361: 1045-57
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 47
    • 60249093674 scopus 로고    scopus 로고
    • Patients undergoing coronary angiography because of chest pain with hepatitis C virus seropositivity have a higher prevalence of obstructive coronary artery disease than a control group
    • Ramdeen N, Aronow WS, Chugh S, Asija A: Patients undergoing coronary angiography because of chest pain with hepatitis C virus seropositivity have a higher prevalence of obstructive coronary artery disease than a control group. Arch Med Sci, 2008; 4: 452-54
    • (2008) Arch Med Sci , vol.4 , pp. 452-454
    • Ramdeen, N.1    Aronow, W.S.2    Chugh, S.3    Asija, A.4
  • 49
    • 70349863391 scopus 로고    scopus 로고
    • Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/ hemostasis
    • van Giezen JJ, Berntsson P, Zachrisson H, Björkman JA: Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/ hemostasis. Thromb Res, 2009; 124(5): 565-71
    • (2009) Thromb Res , vol.124 , Issue.5 , pp. 565-571
    • van Giezen, J.J.1    Berntsson, P.2    Zachrisson, H.3    Björkman, J.A.4
  • 50
    • 48249136077 scopus 로고    scopus 로고
    • Impact of obesity and adipokines on cardiac structure and function in men with first myocardial infarction
    • Piestrzeniewicz K, Łuczak K, Maciejewski M, Goch JH: Impact of obesity and adipokines on cardiac structure and function in men with first myocardial infarction. Arch Med Sci, 2008; 4(2): 152-60
    • (2008) Arch Med Sci , vol.4 , Issue.2 , pp. 152-160
    • Piestrzeniewicz, K.1    Łuczak, K.2    Maciejewski, M.3    Goch, J.H.4
  • 51
    • 68649106901 scopus 로고    scopus 로고
    • Ticagrelor yields consistent dosedependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3
    • Storey RF, Melissa Thornton S et al: Ticagrelor yields consistent dosedependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3. Platelets, 2009; 20(5): 341-48
    • (2009) Platelets , vol.20 , Issue.5 , pp. 341-348
    • Storey, R.F.1    Melissa Thornton, S.2
  • 52
    • 39449133618 scopus 로고    scopus 로고
    • The current role of statins in acute coronary syndrome
    • Kumar A, Cannon CP: The current role of statins in acute coronary syndrome. Arch Med Sci, 2007; 3(4A): S115-25
    • (2007) Arch Med Sci , vol.3 , Issue.4 A
    • Kumar, A.1    Cannon, C.P.2
  • 53
    • 1542299133 scopus 로고    scopus 로고
    • The effect of clopidogrel, aspirin and both antiplatelet drugs on platelet function in patients with peripheral arterial disease
    • Jagroop IA, Matsagas MI, Geroulakos G, Mikhailidis DP: The effect of clopidogrel, aspirin and both antiplatelet drugs on platelet function in patients with peripheral arterial disease. Platelets, 2004; 15(2): 117-25
    • (2004) Platelets , vol.15 , Issue.2 , pp. 117-125
    • Jagroop, I.A.1    Matsagas, M.I.2    Geroulakos, G.3    Mikhailidis, D.P.4
  • 54
    • 62549154026 scopus 로고    scopus 로고
    • Bleeding risk with AZD6140, a reversible P2Y12 receptor antagonist, vs. clopidogrel in patients undergoing coronary artery bypass grafting in the DISPERSE2 trial
    • Husted S, Harrington RA, Cannon CP et al: Bleeding risk with AZD6140, a reversible P2Y12 receptor antagonist, vs. clopidogrel in patients undergoing coronary artery bypass grafting in the DISPERSE2 trial. Int J Clin Pract, 2009; 63(4): 667-70
    • (2009) Int J Clin Pract , vol.63 , Issue.4 , pp. 667-670
    • Husted, S.1    Harrington, R.A.2    Cannon, C.P.3
  • 55
    • 58549110692 scopus 로고    scopus 로고
    • Prevalence of electrocardiographic abnormalities in patients with ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage
    • Lleva P, Aronow WS, Amin H et al: Prevalence of electrocardiographic abnormalities in patients with ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage. Arch Med Sci, 2008; 4(3): 259-62
    • (2008) Arch Med Sci , vol.4 , Issue.3 , pp. 259-262
    • Lleva, P.1    Aronow, W.S.2    Amin, H.3
  • 56
    • 0038387201 scopus 로고    scopus 로고
    • The effect of a loading dose (300 mg) of clopidogrel on platelet function in patients with peripheral arterial disease
    • Matsagas M, Jagroop IA, Geroulakos G, Mikhailidis DP: The effect of a loading dose (300 mg) of clopidogrel on platelet function in patients with peripheral arterial disease. Clin Appl Thromb Hemost, 2003; 9(2): 115-20
    • (2003) Clin Appl Thromb Hemost , vol.9 , Issue.2 , pp. 115-120
    • Matsagas, M.1    Jagroop, I.A.2    Geroulakos, G.3    Mikhailidis, D.P.4
  • 57
    • 35448970166 scopus 로고    scopus 로고
    • Predictors of atrial fibrillation in patients following isolated surgical revascularization. A metaanalysis of 9 studies with 28 786 patients
    • Banach M, Misztal M, Goch A et al: Predictors of atrial fibrillation in patients following isolated surgical revascularization. A metaanalysis of 9 studies with 28 786 patients. Arch Med Sci, 2007; 3(3): 229-39
    • (2007) Arch Med Sci , vol.3 , Issue.3 , pp. 229-239
    • Banach, M.1    Misztal, M.2    Goch, A.3
  • 58
    • 34547753122 scopus 로고    scopus 로고
    • The interaction of coronary microembolization and ischemic preconditioning: A third window of cardioprotection through TNF-alpha
    • Heusch P, Skyschally A, Leineweber K et al: The interaction of coronary microembolization and ischemic preconditioning: A third window of cardioprotection through TNF-alpha. Arch Med Sci, 2007; 3(2): 83-92
    • (2007) Arch Med Sci , vol.3 , Issue.2 , pp. 83-92
    • Heusch, P.1    Skyschally, A.2    Leineweber, K.3
  • 59
    • 2142660111 scopus 로고    scopus 로고
    • Combination antiplatelet therapy in patients with peripheral vascular bypass grafts
    • Smout JD, Mikhailidis DP, Shenton BK, Stansby G: Combination antiplatelet therapy in patients with peripheral vascular bypass grafts. Clin Appl Thromb Hemost, 2004; 10(1): 9-18
    • (2004) Clin Appl Thromb Hemost , vol.10 , Issue.1 , pp. 9-18
    • Smout, J.D.1    Mikhailidis, D.P.2    Shenton, B.K.3    Stansby, G.4
  • 60
    • 48249154157 scopus 로고    scopus 로고
    • Incidence of mortality in 1,040 patients with coronary heart disease or hypertensive heart disease with normal and abnormal left ventricular ejection fraction and with normal and abnormal QRS duration
    • Lai HM, Aronow WS, Rachdev A et al: Incidence of mortality in 1,040 patients with coronary heart disease or hypertensive heart disease with normal and abnormal left ventricular ejection fraction and with normal and abnormal QRS duration. Arch Med Sci, 2008; 4(2): 140-42
    • (2008) Arch Med Sci , vol.4 , Issue.2 , pp. 140-142
    • Lai, H.M.1    Aronow, W.S.2    Rachdev, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.