Comparison of ticagrelor and thienopyridine P2Y12 binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis

Thrombosis Research

Volumn 124, Issue 5, 2009, Pages 565-571

  van Giezen, J J J ^a   Berntsson, Pia ^a   Zachrisson, Helen ^a   Björkman, Jan Arne ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

AZD6140; Bleeding; P2Y12; Platelet aggregation; Thienopyridine; Ticagrelor

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTICOAGULANT AGENT; CLOPIDOGREL; COMPOUND 072; COMPOUND 105; DRUG METABOLITE; PRASUGREL; PURINERGIC P2Y12 RECEPTOR; RADIOLIGAND; THIENOPYRIDINE DERIVATIVE; TICAGRELOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; BINDING ASSAY; BLEEDING; BLEEDING TIME; BLOOD FLOW; CONTINUOUS INFUSION; CONTROLLED STUDY; DOG; DRUG BINDING; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; HEMOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; THROMBOCYTE AGGREGATION;

ADENOSINE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DISEASE MODELS, ANIMAL; DOGS; HEMOSTASIS; HUMANS; PIPERAZINES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PYRIDINES; RATS; RECEPTORS, PURINERGIC P2; THIOPHENES; THROMBOSIS; TICLOPIDINE; TRANSFECTION;

EID: 70349863391     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2009.06.029     Document Type: Article

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