Rapid, Flow Cytometric Assay for NK Alloreactivity Reveals Exceptions to Rules Governing Alloreactivity

Biology of Blood and Marrow Transplantation

Volumn 16, Issue 2, 2010, Pages 179-191

  De Santis, Dianne ^a,b   Foley, Bree A ^a   John, Elisabeth ^b   Senitzer, David ^c   Christiansen, Frank T ^a,b   Witt, Campbell S ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b ROYAL PERTH HOSPITAL   (Australia)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Human; MHC; Natural Killer Cells; Transplantation

Indexed keywords

EPITOPE; HLA ANTIGEN; INTERLEUKIN 2; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; NATURAL KILLER CELL RECEPTOR NKG2A;

ALLOIMMUNITY; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; BLOOD DONOR; CELL ACTIVATION; CELL ASSAY; CELL EXPANSION; CELL FUNCTION; CELL ISOLATION; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; NATURAL KILLER CELL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPRODUCIBILITY; TARGET CELL; UPREGULATION;

CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CELLS, CULTURED; CYTOTOXICITY TESTS, IMMUNOLOGIC; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, B-LYMPHOCYTE; FLOW CYTOMETRY; GENOTYPE; GRAFT VS HOST REACTION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; INTERLEUKIN-2; KILLER CELLS, NATURAL; LIGANDS; LYMPHOCYTE ACTIVATION; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, KIR; TIME FACTORS;

EID: 75149174285     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2009.10.026     Document Type: Article

References (22)

1. Ruggeri L., Capanni M., Urbani E., et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295 (2002) 2097-2100
2. Davies S.M., Ruggieri L., DeForT, et al. Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor. Blood 100 (2002) 3825-3827
3. Colonna M., Brooks E.G., Falco M., Ferrara G.B., and Strominger J.L. Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C. Science 260 (1993) 1121-1124
4. Gumperz J.E., Litwin V., Phillips J.H., Lanier L.L., and Parham P. The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor. J Exp Med 181 (1995) 1133-1144
5. Mandelboim O., Reyburn H.T., Vales-Gomez M., et al. Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules. J Exp Med 184 (1996) 913-922
6. Raulet D.H., Vance R.E., and McMahon C.W. Regulation of the natural killer cell receptor repertoire. Annu Rev Immunol 19 (2001) 291-330
7. Kim S., Poursine-Laurent J., Truscott S.M., et al. Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 436 (2005) 709-713
8. Foley B.A., De Santis D., Van Beelen E., Lathbury L.J., Christiansen F.T., and Witt C.S. The reactivity of Bw4+ HLA-B and HLA-A alleles with KIR3DL1: implications for patient and donor suitability for haploidentical stem cell transplantations. Blood 112 (2008) 435-443
9. Winter C.C., Gumperz J.E., Parham P., Long E.O., and Wagtmann N. Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. J Immunol 161 (1998) 571-577
10. Moesta A.K., Norman P.J., Yawata M., Yawata N., Gleimer M., and Parham P. Synergistic polymorphism at 2 positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3. J Immunol 180 (2008) 3969-3979
11. Pende D., Marcenaro S., Falco M., et al. Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and re-definition of inhibitory KIR specificity. Blood 113 (2008) 3119-3129
12. Chewning J.H., Gudme C.N., Hsu K.C., Selvakumar A., and Dupont B. KIR2DS1-positive NK cells mediate alloresponse against the C2 HLA-KIR ligand group in vitro. J Immunol 179 (2007) 854-868
13. Foley B., De Santis D., Lathbury L., Christiansen F., and Witt C. KIR2DS1-mediated activation overrides NKG2A-mediated inhibition in HLA-C C2-negative individuals. Int Immunol 20 (2008) 555-563
14. Ruggeri L., Mancusi A., Capanni M., Martelli M.F., and Velardi A. Exploitation of alloreactive NK cells in adoptive immunotherapy of cancer. Curr Opin Immunol 17 (2005) 211-217
15. Sun J.Y., Gaidulis L., Miller M.M., et al. Development of a multiplex PCR-SSP method for Killer-cell immunoglobulin-like receptor genotyping. Tissue Antigens 64 (2004) 462-468
16. Alter G., Malenfant J.M., and Altfeld M. CD107a as a functional marker for the identification of natural killer cell activity. J Immunol Methods 294 (2004) 15-22
17. Yawata M., Yawata N., Draghi M., Partheniou F., Little A.M., and Parham P. MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response. Blood 112 (2008) 2369-2380
18. Rose M.J., Brooks A.G., Stewart L.A., Nguyen T.H., and Schwarer A.P. Killer Ig-like receptor ligand mismatch directs NK cell expansion in vitro. J Immunol 183 (2009) 4502-4508
19. Fauriat C., Andersson S., Bjorklund A.T., et al. Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype. J Immunol 181 (2008) 6010-6019
20. Stern M., Ruggeri L., Capanni M., Mancusi A., and Velardi A. Human leukocyte antigens A23, A24, and A32 but not A25 are ligands for KIR3DL1. Blood 112 (2008) 708-710
21. Sakai H. Lymphocyte function in IgA nephropathy. In: Clarkson A.R. (Ed). IgA Nephropathy (1987), Martinus Nijhoss, Boston, MA 176-187
22. Yawata M., Yawata N., Draghi M., Little A.M., Partheniou F., and Parham P. Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function. J Exp Med 203 (2006) 633-645