Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability

DNA Repair

Volumn 9, Issue 2, 2010, Pages 169-176

  Zakaria, Chadi ^a   Kassahun, Henok ^c   Yang, Xiaoming ^a   Labbé, Jean Claude ^b   Nilsen, Hilde ^c   Ramotar, Dindial ^a  

^a MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

APN 1; Base excision; C. elegans; Cell cycle defect; DNA repair; Mutations; RNAi

Indexed keywords

BETA GALACTOSIDASE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; ENDONUCLEASE; GREEN FLUORESCENT PROTEIN; HYDROGEN PEROXIDE; MESYLIC ACID METHYL ESTER; PROTEIN APN 1; UNCLASSIFIED DRUG; URACIL; URACIL DNA GLYCOSIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BLASTOMERE; CAENORHABDITIS ELEGANS; CELL DIVISION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE FREQUENCY; GENE MUTATION; GENETIC COMPLEMENTATION; GENOME; GENOMIC INSTABILITY; GERM LINE; LONGEVITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; REPORTER GENE; RNA INTERFERENCE; SURVIVAL; WORM;

ANIMALS; APOPTOSIS; BACTERIA; BETA-GALACTOSIDASE; BLASTOMERES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL CYCLE; DNA DAMAGE; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENDODEOXYRIBONUCLEASES; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; GENES, REPORTER; GENOME, HELMINTH; GENOMIC INSTABILITY; GREEN FLUORESCENT PROTEINS; LONGEVITY; METHYL METHANESULFONATE; MUTATION; RNA INTERFERENCE; TERT-BUTYLHYDROPEROXIDE; ULTRAVIOLET RAYS; URACIL;

ANIMALIA; CAENORHABDITIS ELEGANS; METAZOA; SACCHAROMYCES CEREVISIAE;

EID: 75149169346     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2009.11.007     Document Type: Article

References (38)

1. Cunningham R.P. DNA glycosylases. Mutat. Res. 383 (1997) 189-196
2. Krokan H.E., Standal R., and Slupphaug G. DNA glycosylases in the base excision repair of DNA. Biochem. J. 325 (1997) 1-16
3. Loeb L.A., and Preston B.D. Mutagenesis by apurinic/apyrimidinic sites. Annu. Rev. Genet. 20 (1986) 201-230
4. Fung H., and Demple B. A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells. Mol. Cell 17 (2005) 463-470
5. Demple B., and Harrison L. Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem. 63 (1994) 915-948
6. Ramotar D. The apurinic-apyrimidinic endonuclease IV family of DNA repair enzymes. Biochem. Cell Biol. 75 (1997) 327-336
7. Vance J.R., and Wilson T.E. Repair of dna strand breaks by the overlapping functions of lesion-specific and non-lesion-specific dna 3′ phosphatases. Mol. Cell. Biol. 21 (2001) 7191-7198
8. Kerins S.M., Collins R., and McCarthy T.V. Characterization of an endonuclease IV 3′-5′ exonuclease activity. J. Biol. Chem. 278 (2003) 3048-3054
9. Jilani A., Vongsamphanh R., Leduc A., Gros L., Saparbaev M., and Ramotar D. Characterization of two independent amino acid substitutions that disrupt the DNA repair functions of the yeast Apn1. Biochemistry 42 (2003) 6436-6445
10. Gros L., Ishchenko A.A., Ide H., Elder R.H., and Saparbaev M.K. The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway. Nucleic Acids Res. 32 (2004) 73-81
11. Barzilay G., and Hickson I.D. Structure and function of apurinic/apyrimidinic endonucleases. Bioessays 17 (1995) 713-719
12. Masson J.Y., and Ramotar D. Normal processing of AP sites in Apn1-deficient Saccharomyces cerevisiae is restored by Escherichia coli genes expressing either exonuclease III or endonuclease III. Mol. Microbiol. 24 (1997) 711-721
13. Chan E., and Weiss B. Endonuclease IV of Escherichia coli is induced by paraquat. Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 3189-3193
14. Johnson A.W., and Demple B. Yeast DNA diesterase for 3′-fragments of deoxyribose: purification and physical properties of a repair enzyme for oxidative DNA damage. J. Biol. Chem. 263 (1988) 18009-18016
15. Popoff S.C., Spira A.I., Johnson A.W., and Demple B. Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 4193-4197
16. Johnson R.E., Torres-Ramos C.A., Izumi T., Mitra S., Prakash S., and Prakash L. Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites [in process citation]. Genes Dev. 12 (1998) 3137-3143
17. Bennett R.A. The Saccharomyces cerevisiae ETH1 gene, an inducible homolog of exonuclease III that provides resistance to DNA-damaging agents and limits spontaneous mutagenesis. Mol. Cell. Biol. 19 (1999) 1800-1809
18. Demple B., Herman T., and Chen D.S. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 11450-11454
19. Hadi M.Z., and Wilson III D.M. Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III. Environ. Mol. Mutagen. 36 (2000) 312-324
20. Masson J.Y., Tremblay S., and Ramotar D. The Caenorhabditis elegans gene CeAPN1 encodes a homolog of Escherichia coli and yeast apurinic/apyrimidinic endonuclease. Gene 179 (1996) 291-293
21. Shatilla A., Leduc A., Yang X., and Ramotar D. Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation. DNA Repair (Amst.) 4 (2005) 655-670
22. Shatilla A., and Ramotar D. Embryonic extracts derived from the nematode Caenorhabditis elegans remove uracil from DNA by the sequential action of uracil-DNA glycosylase and AP (apurinic/apyrimidinic) endonuclease. Biochem. J. 365 (2002) 547-553
23. Shatilla A., Ishchenko A.A., Saparbaev M., and Ramotar D. Characterization of Caenorhabditis elegans exonuclease-3 and evidence that a Mg(2+)-dependent variant exhibits a distinct mode of action on damaged DNA. Biochemistry 44 (2005) 12835-12848
24. Ischenko A.A., and Saparbaev M.K. Alternative nucleotide incision repair pathway for oxidative DNA damage. Nature 415 (2002) 183-187
25. Pothof J., van Haaften G., Thijssen K., Kamath R.S., Fraser A.G., Ahringer J., Plasterk R.H., and Tijsterman M. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev. 17 (2003) 443-448
26. Cunningham R.P., Saporito S.M., Spitzer S.G., and Weiss B. Endonuclease IV (nfo) mutant of Escherichia coli. J. Bacteriol. 168 (1986) 1120-1127
27. Tijsterman M., Pothof J., and Plasterk R.H. Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans. Genetics 161 (2002) 651-660
28. Kenyon C., Chang J., Gensch E., Rudner A., and Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 366 (1993) 461-464
29. Hyenne V., Desrosiers M., and Labbe J.C. C. elegans Brat homologs regulate PAR protein-dependent polarity and asymmetric cell division. Dev. Biol. 321 (2008) 368-378
30. Edgar L.G. Blastomere culture and analysis. Methods Cell Biol. 48 (1995) 303-321
31. Simmer F., Tijsterman M., Parrish S., Koushika S.P., Nonet M.L., Fire A., Ahringer J., and Plasterk R.H. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr. Biol. 12 (2002) 1317-1319
32. Wang S., Zhao Y., Wu L., Tang M., Su C., Hei T.K., and Yu Z. Induction of germline cell cycle arrest and apoptosis by sodium arsenite in Caenorhabditis elegans. Chem. Res. Toxicol. 20 (2007) 181-186
33. Greiss S., Hall J., Ahmed S., and Gartner A. C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis. Genes Dev. 22 (2008) 2831-2842
34. Schumacher B., Alpi A., and Garter A. Cell cycle: check for asynchrony. Curr. Biol. 13 (2003) R560-R562
35. Brauchle M., Baumer K., and Gonczy P. Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos. Curr. Biol. 13 (2003) 819-827
36. Dengg M., Garcia-Muse T., Gill S.G., Ashcroft N., Boulton S.J., and Nilsen H. Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates. EMBO Rep. 7 (2006) 1046-1051
37. Ishchenko A.A., Yang X., Ramotar D., and Saparbaev M. The 3′ → 5′ exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae. Mol. Cell. Biol. 25 (2005) 6380-6390
38. Jilani A., Ramotar D., Slack C., Ong C., Yang X.M., Scherer S.W., and Lasko D.D. Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3′-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage. J. Biol. Chem. 274 (1999) 24176-24186