Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats

Drug Delivery

Volumn 17, Issue 2, 2010, Pages 68-76

  Tofoli, Giovana Radomille ^a,d   Saia Cereda, Ćntia Maria ^a   De Araujo, Daniele Ribeiro ^a,b   Paula, Eneida De ^a   Brito Júnior, Rui Barbosa ^c   Júnior, José Pedrazzoli ^d   Meurer, Eduardo ^d   Proença Barros, F́bio Alessandro ^e   Groppo, Francisco Carlos ^a   Volpato, Maria Cristina ^a   Ranali, José ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSIDADE FEDERAL DO ABC   (Brazil)

^c SÃO LEOPOLDO MANDIC INSTITUTE AND RESEARCH CENTER   (Brazil)

^d So Francisco University   (Brazil)

^e Core Clinical Research ^*  (Brazil)

Author keywords

Liposomes; Local anesthetics; Local toxicity; Mepivacaine; Pharmacokinetics

Indexed keywords

ADRENALIN; LIPOSOME; MEPIADRE; MEPISV; MEPIVACAINE; UNCLASSIFIED DRUG; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DENTISTRY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG SAFETY; ENCAPSULATION; INFLAMMATION; INJECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; RAT; TISSUE REACTION;

ANESTHETICS, LOCAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; DRUG DELIVERY SYSTEMS; EPINEPHRINE; LABORATORY TECHNIQUES AND PROCEDURES; LIPID BILAYERS; LIPOSOMES; MALE; MEPIVACAINE; NERVE BLOCK; RATS; RATS, WISTAR; RESEARCH; SOLUTIONS;

EID: 75149165308     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717540903508995     Document Type: Article

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