The addition of epinephrine to tetracaine injected intrathecally sustains an increase in glutamate concentrations in the cerebrospinal fluid and worsens neuronal injury

Anesthesia and Analgesia

Volumn 93, Issue 4, 2001, Pages 1050-1057

  Oka, Satoe ^a   Matsumoto, Mishiya ^a   Ohtake, Kazunobu ^a   Kiyoshima, Takashi ^a   Nakakimura, Kazuhiko ^a   Sakabe, Takefumi ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; GLUTAMIC ACID; SODIUM CHLORIDE; TETRACAINE;

AMINO ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; HISTOPATHOLOGY; MOTOR DYSFUNCTION; NERVE CELL LESION; NEUROLOGIC EXAMINATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RABBIT; SENSORY DYSFUNCTION; SPINAL CORD INJURY;

EID: 0034814438     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200110000-00051     Document Type: Article

References (15)

1. Lidocaine spinal anesthesia
2. The neurotoxicity of drugs given intrathecally (spinal)
3. Toxicity of spinal local anesthetics
4. A retrospective review of 4767 consecutive spinal anesthetics: Central nervous system complications
5. Prospective study of the incidence of transient radicular irritation in patients undergoing spinal anesthesia
6. Glutamate release and neuronal injury after intrathecal injection of local anesthetics
7. Lidocaine toxicity in primary afferent neurons from the rat
8. Glutamate: A role in normal brain function, anaesthesia, analgesia and CNS injury
9. Glutamate and the pathophysiology of hypoxic-ischemic brain damage
10. The effects of moderate hypothermia and intrathecal tetracaine on glutamate concentrations of intrathecal dialysate and neurologic and histopathologic outcome in transient spinal cord ischemia in rabbits
11. The spinal loop dialysis catheter: Characterization of use in the unanesthetized rat
12. The hydroxyl radical scavenger Nicaraven inhibits glutamate release after spinal injury in rats
13. The influence of dextrose administration on neurologic outcome after temporary spinal cord ischemia in the rabbit
14. The effect of subarachnoid epinephrine and phenylephrine on spinal cord blood flow
15. The addition of phenylephrine contributes to the development of transient neurologic symptoms after spinal anesthesia with 0.5% tetracaine