Impaired hepatocyte regeneration in acute severe hepatic injury enhances effective repopulation by transplanted hepatocytes

Cell Transplantation

Volumn 18, Issue 10-11, 2009, Pages 1081-1092

  Yu, Chun Hsien ^a,b   Chen, Hui Ling ^a   Chen, Ya Hui ^a   Chang, Ming Fu ^a   Chien, Chin Sung ^a   Chang, Mei Hwei ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b TZU CHI UNIVERSITY   (Taiwan)

Author keywords

D Galactosamine; Growth factor; Liver failure; Regeneration; Retrorsine

Indexed keywords

CYTOKINE; GALACTOSAMINE; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MESSENGER RNA; RETRORSINE; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CELL PROLIFERATION; GENE EXPRESSION; HEPATOCYTE TRANSPLANTATION; IMMUNE RESPONSE; INJURY SEVERITY; KINETICS; LIVER FAILURE; LIVER INJURY; LIVER REGENERATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STELLATE CELL; UPREGULATION; WILD TYPE;

ANIMALS; DRUG-INDUCED LIVER INJURY; GALACTOSAMINE; HEPATIC STELLATE CELLS; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; LIVER FAILURE, ACUTE; LIVER REGENERATION; MALE; MATRIX METALLOPROTEINASE 2; PYRROLIZIDINE ALKALOIDS; RATS; RATS, INBRED F344; TRANSFORMING GROWTH FACTOR ALPHA; UP-REGULATION;

RATTUS;

EID: 75149128693     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368909X12483162196647     Document Type: Article

References (43)

1. Alonso, E. M.; Superina, R. A.; Whitington, P. F. Fulminant hepatitis and acute liver failure. In: Kelly, D. A., ed. Diseases of the liver and biliary system in children. London: Blackwell Science Ltd.; 1999:77-94.
2. Aw, M. M.; Mitry, R. R.; Hughes, R. D.; Dhawan, A. Serum hepatocyte growth factor and vascular endothelial growth factor in children with acute liver failure. J. Pediatr. Gastroenterol. Nutr. 44:224-227; 2007.
3. Baumgartner, D.; LaPlante-O'Neill, P. M.; Sutherland, D. E.; Najarian, J. S. Effect of intrasplenic injection of hepatocyte culture supernatants on D-galactosamine-induced liver failure. Eur. Surg. Res. 15:129-135; 1983.
4. Benten, D.; Kumaran, V.; Joseph, B.; Schattenberg, J.; Popov, Y.; Schuppan, D.; Gupta, S. Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat. Hepatology 42:1072-1081; 2005.
5. Braun, K. M.; Degen, J. L.; Sandgren, E. P. Hepatocyte transplantation in a model of toxin-induced liver disease: Variable therapeutic effect during replacement of damaged parenchyma by donor cells. Nat. Med. 6:320-326; 2000.
6. Chen, H. L.; Chang, C. J.; Kong, M. S.; Hunag, F. C.; Lee, H. C.; Lin, C. H.; Liu, C. C.; Lee, I. H.; Wu, T. C.; Wu, S. F.; Ni, Y. H.; Hsu, H. Y.; Chen, D. S.; Chang, M. H. Pediatric fulminant hepatic failure in endemic areas of hepatitis B infection: 15 years after universal hepatitis B vaccine. Hepatology 39:58-63; 2004.
7. Chojkier, M. Toxicity of pyrrolizidine alkaloids. J. Hepatol. 39:437-446; 2003.
8. Clouston, A. D.; Powell, E. E.; Walsh, M. J.; Richardson, M. M.; Demetris, A. J.; Jonsson, J. R. Fibrosis correlates with a ductular reaction in hepatitis C: Roles of impaired replication, progenitor cells and steatosis. Hepatology 41: 809-818; 2005.
9. Dabeva, M. D.; Shafritz, D. A. Activation of progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration. Am. J. Pathol. 143:1606-1620; 1993.
10. Fisher, R. A.; Strom, S. C. Human hepatocyte transplantation: Worldwide results. Transplantation 82:441-449; 2006.
11. Gordon, G. J.; Coleman, W. B.; Grisham, J. W. Liver rethe generation in rats with retrorsine-induced hepatocellular injury. Am. J. Pathol. 156:607-619; 2000.
12. Gupta, S.; Rajvanshi, P.; Sokhi, R. P.; Slehria, S.; Yam, A.; Kerr, A.; Novikoff, P. M. Entry and integration of transplanted hepatocytes in liver plates occur by disruption of hepatic sinusoidal endothelium. Hepatology 29: 509-519; 1999.
13. Ito, M.; Nagata, H.; Yamamoto, T.; Yoshihara, D.; Fox, I. J.; Miyakawa, S. Intrasplenic hepatocyte transplantation prolonged the survival in nagase analbuminemic rats with reliver failure induced by common bile duct ligation. Cell Transplant. 16:547-553; 2007.
14. Joseph, B.; Malhi, H.; Bhargava, K. K.; Palestro, C. J.; McCuskey, R. S.; Gupta, S. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology 123:1677-1685; 2002.
15. Jungermann, K. Metabolic zonation of liver parenchyma. Semin. Liver Dis. 8:329-341; 1988.
16. Katoonizadeh, A.; Nevens, F.; Verslype, C.; Pirenne, J.; Roskams, T. Liver regeneration in acute severe liver impairment: A clinicopathological correlation study. Liver Int. 26:1225-1233; 2006.
17. Kim, T. H.; Mars, W. M.; Stolz, D. B.; Michalopoulos, G. K. Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration. Hepatology 30:75-82; 2000.
18. Knittel, T.; Mehde, M.; Kobold, D.; Saile, B.; Dinter, C.; Ramadori, G. Expression patterns of matrix metalloproteinases and their inhibitors in parenchyma and non-paryn-chymal cells of rat liver: Regulation by TNF-alpha and TGF-beta1. J. Hepatol. 30:48-60; 1999.
19. Kobayashi, N.; Fujiwara, T.; Westerman, K. A.; Inoue, Y.; Sakaguchi, M.; Noguchi, H.; Miyazaki, M.; Cai, J.; Tanaka, N.; Fox, I. J.; Leboulch, P. Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes. Science 287:1258-1262; 2000.
20. Koenig, S.; Stoesser, C.; Krause, P.; Becker, H.; Markus, P. M. Liver repopulation after hepatocellular transplantation: Integration and interaction of transplanted hepatocytes in the host. Cell Transplant. 14:31-40; 2005.
21. Laconi, E.; Oren, R.; Mukhopadhyay, D. K.; Hurston, E.; Laconi, S.; Pani, P.; Dabeva, M. D.; Shafritz, D. A. Long term, near total liver replacement by transplantation of hepatocytes in rats treated with retrorsine. Am. J. Pathol. 158:319-329; 1998.
22. Lee, K. W.; Lee, J. H.; Shin, S. W.; Kim, S. J.; Joh, J. W.; Lee, D. H.; Kim, J. W.; Park, H. Y.; Lee, S. Y.; Lee, H. H.; Park, J. W.; Kim, S. Y.; Yoon, H. H.; Jung, D. H.; Choe, Y. H.; Lee, S. K. Hepatocyte transplantation for glycogen storage disease type Ib. Cell Transplant. 16: 629-637; 2007.
23. Mabuchi, A.; Mullaney, I.; Sheard, P. W.; Hessian, P. A.; Mallard, B. L.; Tawadrous, M. N.; Zimmermann, A.; Senoo, H.; Wheatley, A. M. Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat. J. Hepatol. 40:910-916; 2004.
24. Makowka, L.; Rotstein, L. E.; Falk, R. E.; Falk, J. A.; Zuk, R.; Langer, B.; Blendis, L. M.; Phillips, M. J. Studies into the mechanism of reversal of experimental acute hepatic failure by hepatocyte transplantation. Can. J. Surg. 24:39-44; 1981.
25. Malhi, H.; Annamaneni, P.; Slehria, S.; Joseph, B.; Bhargava, K. K.; Palestro, C. J.; Novikoff, P. M.; Gupta, S. Cyclophosphamide disrupts hepatic sinusoidal endothelium and improves transplanted cell engraftment in rat liver. Hepatology 36:112-121; 2002.
26. Michalopoulos, G. K.; DeFrances, M. C. Liver regeneration. Science 276:60-66; 1997.
27. Mito, M.; Kusano, M.; Sawa, M. Hepatocyte transplantation for hepatic failure. Transplant. Rev. 7:35-43; 1993.
28. Mokowka, L.; Falk, R. E.; Rotstein, L. E.; Falk, J. A.; Nossal, N.; Langer, B.; Blendis, L. M.; Phillips, M. J. Reversal of experimental acute hepatic failure in the rat. J. Surg. Res. 29:479-487; 1980.
29. Newsome, P. N.; Plevris, J. N.; Nelson, L. J.; Hayes, P. C. Animal models of fulminanat hepatic failure. Liver Transplant. 6:21-31; 2000.
30. Ng, V. L.; Sabla, G. E.; Melin-Aladna, H.; Kelly-Lough-nane, N.; Degen, J. L.; Bezerra, J. A. Plasminogen deficiency results in poor clearance of non-fibirn matrix and persistent activation of hepatic stellate cells after an acute injury. J. Hepatol. 35:781-789; 2001.
31. Nieto, N.; Dominguez-Rosales, J. A.; Fontana, L.; Salazar, A.; Armendariz-Borunda, J.; Greenwel, P.; Rojkind, M. Rat hepatic stellate cells contribute to the acute-phase response with increased expression of 1(I) and 1(IV) collagens, tissue inhibitor of metalloproteinase-1, and matrixmetalloproteinase-2 messenger RNAs. Hepatology 33: 597-607; 2001.
32. Oertel, M.; Menthena, A.; Dabeva, M. D.; Shafritz, D. A. Cell competition leads to a high level of normal liver reconstitution by transplanted fetal liver stem/progenitor cells. Gastroenterology 130:507-520; 2006.
33. Overturf, K.; Al-Dhalimy, M.; Tanguay, R.; Brantly, M.; Ou, C. N.; Finegold, M.; Grompe, M. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinemia type I. Nat. Genet. 12: 266-273; 1996.
34. Paku, S.; Nagy, P.; Kopper, L.; Thorgeirsson, S. S. 2-acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: Confocal and electron microscopic studies. Hepatology 39:1353-1361; 2004.
35. Rajvanshi, P.; Kerr, A.; Bhargava, K. K.; Burk, R. D.; Gupta, S. Studies of liver repopulation using the dipeptidyl peptidase IV deficient rats. Hepatology 23:482-496; 1996.
36. Rhim, J. A.; Sandgren, E. P.; Palmiter, R. D.; Brinster, R. L. Complete reconstitution of mouse liver with exogenic hepatocytes. Proc. Natl. Acad. Sci. USA 92:4942-4946; 1995.
37. Sommer, B. G.; Sutherland, D. E.; Matas, A. J.; Simmons, R. L.; Najarian, J. S. Hepatocellular transplantation for treatment of D-galactosamine-induced acute liver failure. Transplant. Proc. 11:578-584; 1979.
38. Sutherland, D. E.; Numata, M.; Matas, A. J.; Simmons, R. L.; Najarian, J. S. Hepatocyte transplantation in acute liver failure. Surgery 82:124-132; 1997.
39. Taub, R. Liver regeneration: From myth to mechanism. Nat. Rev. 5:836-847; 2004.
40. Tsubouchi, H.; Niitani, Y.; Hirono, S.; Nakayama, H.; Gohda, E.; Arakaki, N.; Sakiyama, O.; Takahashi, K.; Kimoto, M.; Kawakami, S. Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzymelinked immunosorbent assay. Hepatology 13:1-5; 1991.
41. Vidal, I.; Blanchard, N.; Alexandre, E.; Gandillet, A.; Chenard-Neu, M. P.; Staedtler, F.; Schumacher, M.; Bachellier, P.; Jaeck, D.; Firat, H.; Heyd, B.; Richert, L. Improved xenogenic hepatocyte implantation into nude mouse liver parenchyma with acute liver failure when followed by repeated anti-Fas antibody (Jo2) treatment. Cell Transplant. 17:507-524; 2008.
42. Yu, C. H.; Chen, H. L.; Chen, W. T.; Ni, Y. H.; Lin, Y. L.; Chang, M. H. Portal hemodynamic changes after hepatocyte transplantation in acute hepatic failure. J. Biomed. Sci. 11:756-763; 2004.
43. Yuan, R. H.; Ogawa, A.; Ogawa, E.; Neufeld, D.; Zhu, L.; Shafritz, D. A. P27Kip1 inactivation provides a proliferative advantage to transplanted hepatocytes in DPPIV/Rag2 double knockout mice after repeated host liver injury. Cell Transplant. 12:907-919; 2003.