Liver repopulation after hepatocellular transplantation: Integration and interaction of transplanted hepatocytes in the host

Cell Transplantation

Volumn 14, Issue 1, 2005, Pages 31-40

  Koenig, Sarah ^a,b   Stoesser, Claudia ^a   Krause, Petra ^a   Becker, Heinz ^a   Markus, Peter M ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Cell adhesion molecules; Hepatocyte transplantation; Intercellular contacts; Matrix metalloproteinases; Repopulation

Indexed keywords

A GEL VC2; ALEXA FLUOR 488; ALEXA FLUOR 568; ANTIGEN; C3595; CELL ADHESION MOLECULE; CONNEXIN 32; DIPEPTIDYL PEPTIDASE IV; GELATINASE A; MATRIX METALLOPROTEINASE; MCA276R; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY A GEL VC2; MONOCLONAL ANTIBODY C3595; MONOCLONAL ANTIBODY MCA276R; MONOCLONAL ANTIBODY OX 61; OX 43 ANTIGEN; OX 61; RETRORSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CELL DIVISION; CELL INTERACTION; CELL PROLIFERATION; DEGRADATION; ENDOTHELIUM; EXTRACELLULAR MATRIX; FLUORESCENCE ACTIVATED CELL SORTING; GAP JUNCTION; HEPATOCYTE TRANSPLANTATION; HOST; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INTEGRATION; LIVER REGENERATION; LIVER SINUSOID; NONHUMAN; PARTIAL HEPATECTOMY; PERMEABILITY BARRIER; PRIORITY JOURNAL; RAT;

EID: 15244348131     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000005783983322     Document Type: Article

References (37)

1. Allen, K. J.; Soriano, H. E. Liver cell transplantation: The road to clinical application. J. Lab. Clin. Med. 138:298-312; 2001.
2. Callejas, N. A.; Casado, M.; Diaz-Guerra, M. J.; Bosca, L.; Martin-Sanz, P. Expression of cyclooxygenase-2 promotes the release of matrix metalloproteinase-2 and -9 in fetal rat hepatocytes. Hepatology 33:860-867; 2001.
3. Corbin, I. R.; Buist, R.; Volotovskyy, V.; Peeling, J.; Zhang, M.; Minuk, G. Y. Regenerative activity and liver function following partial hepatectomy in the rat using (31)P-MR spectroscopy. Hepatology 36:345-353; 2002.
4. Court, F. G.; Wemyss-Holden, S. A.; Dennison, A. R.; Maddern, G. J. The mystery of liver regeneration. Br. J. Surg. 89:1089-1095; 2002.
5. De Roos, W. K.; von Geusau, B. A.; Bouwman, E.; van Dierendonck, J. H.; Borel Rinkes, I. H.; Terpstra, O. T. Monitoring engraftment of transplanted hepatocytes in recipient liver with 5-bromo-2′-deoxyuridine. Transplantation 63:513-518; 1997.
6. Fallon, M. B.; Nathanson, M. H.; Mennone, A.; Saez, J. C.; Burgstahler, A. D.; Anderson, J. M. Altered expression and function of hepatocyte gap junctions after common bile duct ligation in the rat. Am. J. Physiol. 268:C1186-1194; 1995.
7. Fujino, M.; Li, X. K.; Kitazawa, Y.; Funeshima, N.; Guo, L.; Okuyama, T.; Amano, T.; Amemiya, H.; Suzuki, S. Selective repopulation of mice liver after Fas-resistant hepatocyte transplantation. Cell Transplant. 10:353-361; 2001.
8. Fujioka, H.; Hunt, P. J.; Rozga, J.; Wu, G. D.; Cramer, D. V.; Demetriou, A. A.; Moscioni, A. D. Carboxyfluorescein (CFSE) labelling of hepatocytes for short-term localization following intraportal transplantation. Cell Transplant. 3:397-408; 1994.
9. Gingalewski, C.; De Maio, A. Differential decrease in connexin 32 expression in ischemic and nonischemic regions of rat liver during ischemia/reperfusion. J. Cell Physiol. 171:20-27; 1997.
10. Gupta, S.; Rajvanshi, P.; Sokhi, R.; Slehria, S.; Yam, A.; Kerr, A.; Novikoff, P. M. Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium. Hepatology 29(2):509; 1999.
11. Gupta S. Hepatocyte transplantation. J. Gastroenterol. Hepatol. 17:S287-S293; 2002.
12. Gupta, S.; Bhargava, K. K.; Novikoff, P. M. Mechanisms of cell engraftment during liver repopulation with transplanted hepatocytes. Semin. Liver Dis. 19:15-26; 1999.
13. Gupta, S.; Gorla, G. R.; Irani, A. N. Hepatocyte transplantation: Emerging insights into mechanism of liver repopulation and their relevance to potential therapies. J. Hepatol. 30:162-170; 1999.
14. Gupta, S.; Rajvanshi, P.; Lee, C. D. Integration of transplanted hepatocytes in host liver plates demonstrated with dipeptidyl peptidase IV deficient rats. Proc. Natl. Acad. Sci. USA 92:5860-5864; 1995.
15. Gupta, S.; Rajvanshi, P.; Malhi, H.; Slehria, S.; Sokhi, R. P.; Vasa, S. R.; Dabeva, M.; Shafritz, D. A.; Kerr, A. Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver. Am. J. Physiol. Gastrointest. Liver Physiol. 279:G815-826; 2000.
16. Gupta, S.; Vasa, S. R.; Rajvanshi, P.; Zuckier, L. S.; Palestro, C. J.; Bhargava, K. K. Analysis of hepatocyte distribution and survival in vascular beds with cells marked by 99mTC or endogenous dipeptidyl peptidase IV activity. Cell Transplant. 6:377-386; 1997.
17. Haruyama, T.; Ajioka, I.; Akaike, T.; Watanabe, Y. Regulation and significance of hepatocyte-derived matrix metalloproteinases in liver remodeling. Biochem. Biophys. Res. Commun. 272:681-686; 2000.
18. Hyon, S. H.; Ceballos, M. C.; Barbich, M.; Groppa, R.; Grosembacher, L.; Vieiro, M. M.; Barcan, L.; Algranati, S.; Litwak, L.; Argibay, P. F. Effect of the embolization of completely unpurified islets on portal vein pressure and hepatic biochemistry in clinical practice. Cell Transplant. 13:61-65; 2004.
19. Joseph, B.; Malhi, H.; Bhargava, K. K.; Palestra, C. J.; McCuskey, R. S.; Gupta, S. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology 123:1677-1685; 2002.
20. Knittel, T.; Mehde, M.; Grundmann, A.; Saile, B.; Scharf, J. G.; Ramadori, G. Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat. Histochem. Cell Biol. 113:443-453; 2000.
21. Krishna Vanaja, D.; Sivakumar, B.; Jesudasan, R. A.; Singh, L.; Janardanasarma, M. K.; Habibullah, C. M. In vivo identification, survival, and functional efficacy of transplanted hepatocytes in acute liver failure mice model by FISH using Y-chromosome probe. Cell Transplant. 7: 267-273; 1998.
22. Laconi, E.; Oren, R.; Mukhopadhyay, D. K.; Hurston, E.; Laconi, S.; Pani, P.; Dabeva, M. D.; Shafritz, D. A. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am. J. Pathol. 153:319-329; 1998.
23. Lojda, Z. Studies on dipeptidyl(amino)peptidase IV (glycyl-proline naphthylamidase). II. Blood vessels. Histochemistry 59:153-166; 1979.
24. Malhi, H.; Annamaneni, P.; Slehria, S.; Joseph, B.; Bhargava, K. K.; Palestra, C. J.; Novikoff, P. M.; Gupta, S. Cyclophosphamide disrupts hepatic sinusoidal endothelium and improves transplanted cell engraftment in rat liver. Hepatology 36:112-221; 2002.
25. Malhi, H.; Gorla, G. R.; Irani, A. N.; Annamaneni, P.; Gupta, S. Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulation. Proc. Natl. Acad. Sci. USA 99:13114-13119; 2002.
26. Markus, P. M.; Koenig, S.; Krause, P.; Becker, H. Selective intraportal transplantation of Dil-marked isolated rat hepatocytes. Cell Transplant. 6:455-462; 1997.
27. Markus, P. M.; Krause, P.; Becker, H.; Roher, H. D. Hepatocyte transplantation-an alternative to orthotopic liver transplantation? Z. Tx Med. 6:138-140; 1994.
28. McKenna, G. J.; Chen, Y.; Smith, R. M.; Meneghetti, A.; Ong, C.; McMaster, R.; Scudamore, C. H.; Chung, S. W. A role for matrix metalloproteinases and tumor host interaction in hepatocellular carcinomas. Am. J. Surg. 183: 588-594; 2002.
29. Rajvanshi, P.; Kerr, A.; Bhargava, K. K.; Burk, R. D.; Gupta, S. Studies of liver repopulation using the dipeptidyl peptidase IV deficient rat and other rodents: Cell size and structure relationships regulate capacity for increased transplanted hepatocyte mass in the liver lobe. Hepatology 23:482-496; 1996.
30. Rozga, J.; Holzman, M.; Moscioni, A. D.; Fujioka, H.; Morsiani, E.; Demetriou, A. A. Repeated intraportal hepatocyte transplantation in analbuminemic rats. Cell Transplant. 4:237-243; 1995.
31. Seglen, P. O. Preparation of isolated rat liver cells. Methods Cell Biol. 13:29-83; 1976.
32. Sterling, R. K.; Fisher, R. A. Liver transplantation. Living donor, hepatocyte, and xenotransplantation. Clin. Liver Dis. 5:431-460; 2001.
33. Thalheimer, U.; Capra, F. Liver transplantation: Making the best out of what we have. Dig. Dis. Sci. 47:945-953; 2002.
34. Thompson, N. L.; Hixson, D. C.; Callanan, H.; Panzica, M.; Flanagan, D.; Paris, R. A.; Hong, W. J.; Hartel-Schenk, S.; Doyle, D. A Fischer rat substrain deficient in dipeptidyl peptidase IV activity makes normal steady-state RNA levels and an altered protein. Use as a liver-cell transplantation model. Biochem. J. 273:497-502; 1991.
35. Unwin, P. N.; Zampighi, G. Structure of the junction between communicating cells. Nature 283:545-549; 1980.
36. Yamaoka, K.; Nouchi, T.; Kohashi, T.; Marumo, F.; Sato, C. Expression of gap junction protein connexin 32 in chronic liver diseases. Liver 20:104-107; 2000.
37. Yamaoka, K.; Nouchi, T.; Tazawa, J.; Hiranuma, S.; Marumo, F.; Sato, C. Expression of gap junction protein connexin 32 and E-cadherin in human hepatocellular carcinoma. J. Hepatol. 22:536-539; 1995.