The application of micro-analytical techniques to biomedical analysis

Current Pharmaceutical Analysis

Volumn 5, Issue 3, 2009, Pages 208-228

  Kalish, Heather ^a   Phillips, Terry M ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

Bioanalysis; Chip based CE; Lab on a chip; Micro HPLC; Microfluidics

Indexed keywords

CAPILLARY ELECTROPHORESIS; CHROMATOGRAPHY; HUMAN; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; MICROANALYSIS; NANOANALYSIS; NANODEVICE; NEWBORN; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; PROTEIN MICROARRAY; REVIEW;

EID: 75149128190     PISSN: 15734129     EISSN: None     Source Type: Journal    
DOI: 10.2174/157341209788922057     Document Type: Review

References (141)

1. He, T.; Quinn, D.; Fu, E.; Wang, Y.K. Analysis of diagnostic metabolites by capillary electrophoresis-mass spectrometry. J. Chromatogr. B Biomed. Sci. Appl., 1999, 727(1-2), 43-52.
2. Elgstoen, K.B.; Zhao, J.Y.; Anacleto, J.F.; Jellum, E., Potential of capillary electrophoresis, tandem mass spectrometry and coupled capillary electrophoresis-tandem mass spectrometry as diagnostic tools. J. Chromatogr. A, 2001, 914(1-2), 265-275.
3. Altria, K.D. Overview of capillary electrophoresis and capillary electrochromatography. J. Chromatogr. A, 1999, 856(1-2), 443-463.
4. Hage, D. S., Affinity chromatography: a review of clinical applications. Clin. Chem., 1999, 45(5), 593-615.
5. Kutter, J.P. Current developments in electrophoretic and chromatogrpahic separation methods on microfabricated devices. Trends Anal. Chem., 2000, 19(6), 352-363.
6. Legido-Quigley, C.; Marlin, N.D.; Melin, V.; Manz, A.; Smith, N.W. Advances in capillary electrochromatography and micro-high performance liquid chromatography monolithic columns for separation science. Electrophoresis, 2003, 24(6), 917-944.
7. Li, Y.; Xiang, R.; Wilkins, J.A.; Horvath, C., Capillary electrochromatography of peptides and proteins. Electrophoresis, 2004, 25(14), 2242-2256.
8. Sung, W.C.; Chen, S.H. Recent advances in pharmacokinetic applications of capillary electrophoresis. Electrophoresis, 2001, 22(19), 4244-4248.
9. Thormann, W.; Lurie, I.S.; McCord, B.; Marti, U.; Cenni, B.; Malik, N. Advances of capillary electrophoresis in clinical and forensic analysis (1999-2000). Electrophoresis, 2001, 22(19), 4216-4243.
10. Verpoorte, E., Microfluidic chips for clinical and forensic analysis. Electrophoresis, 2002, 23(5), 677-712.
11. Dittrich, P.S.; Tachikawa, K.; Manz, A., Micro total analysis systems. Latest advancements and trends. Anal. Chem., 2006, 78(12), 3887-3908.
12. Moller, J.G.; Stass, H.; Heinig, R.; Blaschke, G., Capillary electrophoresis with laser-induced fluorescence: a routine method to determine moxifloxacin in human body fluids in very small sample volumes. J. Chromatogr. B Biomed. Sci. Appl., 1998, 716(1-2), 325-334.
13. Prezelj, M.; Neubauer, D.; Derganc, M. Measurement of purines in urine by capillary electrophoresis for estimating the degree of hypoxia in infants. Clin. Chem. Lab. Med., 2000, 38(7), 623-628.
14. Sanchez-Hernandez, L.; Crego, A.L.; Marina, M.L.; Garcia-Ruiz, C. Sensitive chiral analysis by CE: an update. Electrophoresis, 2008, 29(1), 237-251.
15. Guzman, N.A.; Stubbs, R.J.; Phillips, T.M. Determination of inflammatory biomarkers by immunoaffinity capillry electrophoresis. Drug Discov. Today Technol., 2006, 3(1), 29-37.
16. Dolnik, V., Capillary electrophoresis of proteins 2005-2007. Electrophoresis, 2008, 29(1), 143-156.
17. Kasicka, V., Recent developments in CE and CEC of peptides. Electrophoresis, 2008, 29(1), 179-206.
18. Musenga, A.; Mandrioli, R.; Morganti, E.; Fanali, S.; Raggi, M. A. Enantioselective analysis of amisulpride in pharmaceutical formulations by means of capillary electrophoresis. J. Pharm. Biomed. Anal., 2008, 46(5), 966-970.
19. Hennion, M.C.; Pichon, V., Immuno-based sample preparation for trace analysis. J. Chromatogr. A, 2003, 1000(1-2), 29-52.
20. Rathore, A.S., Joule heating and determination of temperature in capillary electrophoresis and capillary electrochromatography columns. J. Chromatogr. A, 2004, 1037(1-2), 431-443.
21. Xuan, X. Joule heating in electrokinetic flow. Electrophoresis, 2008, 29(1), 33-43.
22. Breadmore, M.C.; Theurillat, R.; Thormann, W. Determination of ribavirin in human serum and plasma by capillary electrophoresis. Electrophoresis, 2004, 25(10-11), 1615-1622.
23. Vernez, L.; Thormann, W.; Krahenbuhl, S. Analysis of carnitine and acylcarnitines in urine by capillary electrophoresis. J. Chromatogr. A, 2000, 895(1-2), 309-316.
24. Desiderio, C.; Rudaz, S.; Raggi, M.A.; Fanali, S. Enantiomeric separation of fluoxetine and norfluoxetine in plasma and serum samples with high detection sensitivity capillary electrophoresis. Electrophoresis, 1999, 20(17), 3432-3438.
25. Easley, C.J.; Jin, L.J.; Presto, E.K.B.; Jellum, E.; Landers, J.P.; Ferrance, J.P. Capillary electrophoresis with laser-induced fluorescence detection for laboratory diagnosis of galactosemia. J. Chromatogr. A, 2003, 1004(1-2), 29-37.
26. Kong, Y.; Zheng, N.; Zhang, Z.; Gao, R. High-performance capillary zone electrophoretic assay for markers of diabetic nephropathy in plasma and urine. J. Chromatogr. A, 2003, 987(1-2), 477-483.
27. Bossuyt, X.; Lissoir, B.; Marien, G.; Maisin, D.; Vunckx, J.; Blanckaert, N.; Wallemacq, P. Automated serum protein electrophoresis by Capillarys. Clin. Chem. Lab. Med., 2003, 41(5), 704-710.
28. Noll, B.O.; Debelak, H.; Uhlmann, E. Identification and quantification of GC-rich oligodeoxynucleotides in tissue extracts by capillary gel electrophoresis. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2007, 847(2), 153-161.
29. Sanchez, L.; Gonzalez, R.; Crego, A.L.; Cifuentes, A. A simple capillary gel electrophoresis approach for efficient and reproducible DNA separations. Analysis of genetically modified soy and maize. J. Sep. Sci., 2007, 30(4), 579-585.
30. Szilagyi, A.; Bonn, G.K.; Guttman, A. Capillary gel electrophoresis analysis of G-quartet forming oligonucleotides used in DNA-protein interaction studies. J. Chromatogr. A, 2007, 1161(1-2), 15-21.
31. Poitevin, M.; Morin, A.; Busnel, J.M.; Descroix, S.; Hennion, M.C.; Peltre, G. Comparison of different capillary isoelectric focusing methods - use of "narrow pH cuts" of carrier ampholytes as original tools to improve resolution. J. Chromatogr. A, 2007, 1155(2), 230-236.
32. Lacunza, I.; Diez-Masa, J.C.; de Frutos, M. CIEF with hydrodynamic and chemical mobilization for the separation of forms of alpha-1-acid glycoprotein. Electrophoresis, 2007, 28(8), 1204-1213.
33. Lacunza, I.; Kremmer, T.; Diez-Masa, J. C.; Sanz, J.; de Frutos, M. Comparison of alpha-1-acid glycoprotein isoforms from healthy and cancer patients by capillary IEF. Electrophoresis, 2007, 28(23), 4447-4451.
34. Kaplan, L.A.; Pesce, A.J.; Kazmierczak, S.C. Clinical chemistry : theory, analysis, and correlation. 3rd ed.; Mosby: St. Louis, 1996, p. xvii, p. 1211.
35. Jager, A.V.; Tavares, M.F. M. Novel approach for the analysis of glycated hemoglobin using capillary isoelectric focusing with chemical mobilization. J. Chromatogr. B, 2003, 785, 285-292.
36. Schappler, J.; Guillarme, D.; Rudaz, S.; Veuthey, J.L., Microemulsion electrokinetic chromatography hyphenated to atmospheric pressure photoionization mass spectrometry. Electrophoresis, 2008, 29(1), 11-19.
37. Scherz, H.; Huck, C.W.; Bonn, G.K. CEC and EKC of natural compounds. Electrophoresis, 2007, 28(11), 1645-1657.
38. Huo, Y.; Kok, W.T. Recent applications in CEC. Electrophoresis, 2008, 29(1), 80-93.
39. Mangelings, D.; Saevels, J.; Vander Heyden, Y., Enantiomeric impurity determination of levetiracetam using capillary electrochromatography. J. Sep. Sci., 2006, 29(18), 2827-2836.
40. Bragg, W.; Norton, D.; Shamsi, S.A., Optimized separation of beta-blockers with multiple chiral centers using capillary electrochromatography-mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2008, 875, 304-316.
41. Xie, G.; Su, M.; Li, P.; Gu, X.; Yan, C.; Qiu, Y.; Li, H.; Jia, W. Analysis of urinary metabolites for metabolomic study by pressurized CEC. Electrophoresis, 2007, 28(23), 4459-4468.
42. Amundsen, L.K.; Siren, H. Immunoaffinity CE in clinical analysis of body fluids and tissues. Electrophoresis, 2007, 28(1-2), 99-113.
43. Guzman, N.A.; Blanc, T.; Phillips, T.M. Immunoaffinity capillary electrophoresis as a powerful strategy for the quantification of low-abundance biomarkers, drugs, and metabolites in biological matrices. Electrophoresis, 2008, 29, 3259-3278.
44. Guzman, N.A.; Phillips, T.M. Immunoaffinity CE for proteomics studies. Anal. Chem., 2005, 77(3), 61A-67A.
45. Phillips, T.M., Analysis of single-cell cultures by immunoaffinity capillary electrophoresis with laser-induced fluorescence detection. Luminescence, 2001, 16(2), 145-152.
46. Balasubramanyam, A.; Mersmann, H.; Jahoor, F.; Phillips, T.M.; Sekhar, R.V.; Schubert, U.; Brar, B.; Iyer, D.; Smith, E.O.; Takahashi, H.; Lu, H.; Anderson, P.; Kino, T.; Henklein, P.; Kopp, J.B. Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice. Am. J. Physiol. Endocrinol. Metab., 2007, 292(1), E40-E48.
47. Benavente, F.; Hernandez, E.; Guzman, N.A.; Sanz-Nebot, V.; Barbosa, J. Determination of human erythropoietin by on-line immunoaffinity capillary electrophoresis: a preliminary report. Anal. Bioanal. Chem., 2007, 387(8), 2633-2639.
48. Harrison, D.J.; Manz, A.; Fan, Z.H.; Ludi, H.; Widmer, H.M. Capillary Electrophoresis and Sample Injection Systems Integrated on a Planar Glass Chip. Anal. Chem., 1992, 64(17), 1926-1932.
49. Colyer, C.L.; Tang, T.; Chiem, N.; Harrison, D.J. Clinical potential of microchip capillary electrophoresis systems. Electrophoresis, 1997, 18(10), 1733-1741.
50. Guijt, R.M.; Baltussen, E.; van Dedem, G.W. Use of bioaffinity interactions in electrokinetically controlled assays on microfabricated devices. Electrophoresis, 2002, 23(6), 823-835.
51. Deng, Y.; Henion, J.; Li, J.; Thibault, P.; Wang, C.; Harrison, D.J. Chip-based capillary electrophoresis/mass spectrometry determination of carnitines in human urine. Anal. Chem., 2001, 73(3), 639-646.
52. Beard, N.P.; de Mello, A.J. A polydimethylsiloxane/glass capillary electrophoresis microchip for the analysis of biogenic amines using indirect fluorescence detection. Electrophoresis, 2002, 23(11), 1722-1730.
53. Kameoka, J.; Craighead, H. G.; Zhang, H. W.; Henion, J. A polymeric microfluidic chip for CE/MS determination of small molecules. Anal. Chem., 2001, 73(9), 1935-1941.
54. Pumera, M.; Wang, J.; Grushka, E.; Polsky, R. Gold nanoparticleenhanced microchip capillary electrophoresis. Anal. Chem., 2001, 73(22), 5625-5628.
55. Deng, Y.; Zhang, H.; Henion, J. Chip-based quantitative capillary electrophoresis/mass spectrometry determination of drugs in human plasma. Anal. Chem., 2001, 73(7), 1432-1439.
56. Ermakov, S.V.; Jacobson, S.C.; Ramsey, J.M. Computer simulations of electrokinetic injection techniques in microfluidic devices. Anal. Chem., 2000, 72(15), 3512-3517.
57. Blas, M.; Delaunay, N.; Ferrigno, R.; Rocca, J.L. Numerical simulations of the second-order electrokinetic bias observed with the gated injection mode in chips. Electrophoresis, 2007, 28(17), 2961-2970.
58. Blas, M.; Delaunay, N.; Rocca, J.L. Electrokinetic-based injection modes for separative microsystems. Electrophoresis, 2008, 29(1), 20-32.
59. Ying, F.; Mastrangelo, C.H.; Burke, D.T.; Burns, M.A. Electrophoretic separations using sweeping fields. Electrophoresis, 1998, 19(8-9), 1388-1393.
60. Rocklin, R.D.; Ramsey, RS.; Ramsey, J.M., A microfabricated fluidic device for performing two-dimensional liquid-phase separations. Anal. Chem., 2000, 72(21), 5244-5249.
61. Phillips, T.M.; Wellner, E.F. Analysis of inflammatory biomarkers from tissue biopsies by chip-based immunoaffinity CE. Electrophoresis, 2007, 28(17), 3041-3048.
62. Wachs, T.; Henion, J. Electrospray device for coupling microscale separations and other miniaturized devices with electrospray mass spectrometry. Anal. Chem., 2001, 73(3), 632-638.
63. Schultz, G.A.; Corso, T.N.; Prosser, S.J.; Zhang, S. A fully integrated monolithic microchip electrospray device for mass spectrometry. Anal. Chem., 2000, 72(17), 4058-4063.
64. Gauthier, G.H. HPLC microfluidic chip advances nanospray LCMS performance in proteomic and pharmaceutical analysis. LCGC The Peak, 2006, 7-15.
65. Guijt, R.M.; Baltussen, E.; van der Steen, G.; Frank, H.; Billiet, H.; Schalkhammer, T.; Laugere, F.; Vellekoop, M.; Berthold, A.; Sarro, L.; van Dedem, G.W. Capillary electrophoresis with on-chip four-electrode capacitively coupled conductivity detection for application in bioanalysis. Electrophoresis, 2001, 22(12), 2537-2541.
66. Fanguy, J.C.; Henry, C.S. The analysis of uric acid in urine using microchip capillary electrophoresis with electrochemical detection. Electrophoresis, 2002, 23 (5), 767-773.
67. Raisi, F.; Belgrader, P.; Borkholder, D.A.; Herr, A.E.; Kintz, G.J.; Pourhamadi, F.; Taylor, M. T.; Northrup, M. A., Microchip isoelectric focusing using a miniature scanning detection system. Electrophoresis, 2001, 22(11), 2291-2295.
68. Shi, B.; Huang, W.; Cheng, J. Determination of neurotransmitters in PC 12 cells by microchip electrophoresis with fluorescence detection. Electrophoresis, 2007, 28(10), 1595-1600.
69. Peng, Y.; Pallandre, A.; Tran, N.T.; Taverna, M., Recent innovations in protein separation on microchips by electrophoretic methods. Electrophoresis, 2008, 29(1), 157-178.
70. Sung, W.C.; Lee, G.B.; Tzeng, C.C.; Chen, S.H. Plastic microchip electrophoresis for genetic screening: the analysis of polymerase chain reactions products of fragile X (CGG)n alleles. Electrophoresis, 2001, 22(6), 1188-1193.
71. Hofgartner, W.T.; Huhmer, A.F.; Landers, J.P.; Kant, J.A. Rapid diagnosis of herpes simplex encephalitis using microchip electrophoresis of PCR products. Clin. Chem., 1999, 45(12), 2120-2128.
72. Vrouwe, E.X.; Luttge, R.; Vermes, I.; van den Berg, A. Microchip capillary electrophoresis for point-of-care analysis of lithium. Clin. Chem., 2007, 53(1), 117-123.
73. Phillips, T.M.; Wellner, E. Measurement of neuropeptides in clinical samples using chip-based immunoaffinity capillary electrophoresis. J. Chromatogr. A, 2006, 1111(1), 106-111.
74. Wellner, E.; Kalish, H. A chip-based immunoaffinity capillary electrophoresis assay for assessing hormones in human biological fluids. Electrophoresis, 2008, 29(16): 3477-3483.
75. Kawabata, T.; Wada, H.G.; Watanabe, M.; Satomura, S. Electrokinetic analyte transport assay for alpha-fetoprotein immunoassay integrates mixing, reaction and separation on-chip. Electrophoresis, 2008, 29(7), 1399-1406.
76. Gong, M.; Wehmeyer, K.R.; Limbach, P.A.; Heineman, W.R. Frontal analysis in microchip CE: a simple and accurate method for determination of protein-DNA dissociation constant. Electrophoresis, 2007, 28(5), 837-842.
77. Stettler, A.R.; Krattiger, P.; Wennemers, H.; Schwarz, M.A. Electrophoretic affinity measurements on microchip. Determination of binding affinities between diketopiperazine receptors and peptide ligands. Electrophoresis, 2007, 28(11), 1832-1838.
78. Saito, Y.; Jinno, K.; Greibrokk, T. Capillary columns in liquid chromatography: between conventional columns and microchips. J. Sep. Sci., 2004, 27(17-18), 1379-1390.
79. Horvath, C.G.; Preiss, B.A.; Lipsky, S.R. Fast liquid chromatography - an investigation of operating parameters and separation of nucleotides on pellicular ion exchangers. Anal. Chem., 1967, 39(12), 1422-1428.
80. Eeltink, S.; Decrop, W.M.C.; Rozing, G.P.; Schoenmakers, P.J.; Kok, W.T. Comparison of the efficiency of microparticulate and monolithic capillary columns. J. Sep. Sci., 2004, 27(17-18), 1431-1440.
81. Lancas, F.M.; Rodrigues, J.C.; Freitas, S.D. Preparation and use of packed capillary columns in chromatographic and related techniques. J. Sep. Sci., 2004, 27(17-18), 1475-1482.
82. Pruss, A.; Kempter, C.; Gysler, J.; Jira, T. Evaluation of packed capillary liquid chromatography columns and comparison with conventional-size columns. J. Chromatogr. A, 2004, 1030(1-2), 167-176.
83. Siouffi, A.M., Silica gel-based monoliths prepared by the sol-gel method: facts and figures. J. Chromatogr. A, 2003, 1000(1-2), 801-818.
84. Svec, F. Organic polymer monoliths as stationary phases for capillary HPLC. J. Sep. Sci., 2004, 27(17-18), 1419-1430.
85. Vissers, J.P.C.; Claessens, H.A.; Cramers, C.A. Microcolumn liquid chromatography: Instrumentation, detection and applications. J. Chromatogr. A, 1997, 779(1-2), 1-28.
86. Phillips, T.M.; Smith, P.D. Immunoaffinity analysis of substance P in complex biological fluids: Analysis of sub-microliter samples. J. Liq. Chromatogr. Rel. Technol., 2002, 25, 2889-2900.
87. Peoples, M.C.; Phillips, T.M.; Karnes, H.T. A capillary-based microfluidic instrument suitable for immunoaffinity chromatography. J. Chromatogr., 2007, 848, 200-207.
88. Yin, H.; Killeen, K.; Brennen, R.; Sobek, D.; Werlich, M.; van de Goor, T. Microfluidic chip for peptide analysis with an integrated HPLC column, sample enrichment column, and nanoelectrospray tip. Anal. Chem., 2005, 77(2), 527-533.
89. Lazar, I.M.; Trisiripisal, P.; Sarvaiya, H.A. Microfluidic liquid chromatography system for proteomic applications and biomarker screening. Anal. Chem., 2006, 78(15), 5513-5524.
90. Knox, J.H.; Parcher, J.F. Effect of column to particle diameter ratio on dispersion of unsorbed solutes in chromatography. Anal. Chem., 1969, 41(12), 1599-1606.
91. Hsieh, S.C.; Jorgenson, J.W. Preparation and evaluation of slurrypacked liquid chromatography microcolumns with inner diameters from 12 to 33 mu m. Anal. Chem., 1996, 68(7), 1212-1217.
92. Greibrokk, T.; Andersen, T. High-temperature liquid chromatography. J. Chromatogr. A, 2003, 1000(1-2), 743-755.
93. Kennedy, R.T.; Jorgenson, J.W. Preparation and evaluation of packed capillary liquid-chromatography columns with inner diameters from 20-Mu-M to 50-Mu-M. Anal. Chem., 1989, 61(10), 1128-1135.
94. Knox, J.H.; Gilbert, M.T. Kinetic optimization of straight opentubular liquid-chromatography. J. Chromatogr., 1979, 186, 405-418.
95. Tsuda, T.; Novotny, M. Packed microcapillary columns in high-performance liquid-chromatography. Anal. Chem., 1978, 50(2), 271-275.
96. Tsuda, T.; Tanaka, I.; Nakagawa, G. Packed microcapillary liquid-chromatography with reduced Id columns. J. Chromatogr., 1982, 239, 507-513.
97. Doyle, C.A.; Dorsey, J.G. Reversed-Phase HPLC: Preparation and Characterization of Reversed Phase Stationary Phases. In Handbook of HPLC, Katz, E.E.R.; Schoenmakers, P.; Miller, N., Eds;. Marcel Dekker: New York, 1998; vol. 78, pp. 293-323.
98. Caude, M. J.A. Normal-phase liquid chromatography. In Handbook of HPLC, Katz, E.E.R.; Schoenmakers, P.; Miller, N.; Eds.; Marcel Dekker: New York, 1998; vol. 78, pp. 325-363.
99. Hage, D.S. Affinity chromatography. In Handbook of HPLC, Katz, E.E.R.; Schoenmakers, P.; Miller, N.; Eds.; Marcel Dekker: New York, 1998; vol. 78, pp. 483-498.
100. Smith, R.E. HPLC of Ions: Ion-Exchange Chromatography. In Handbook of HPLC, Katz, E.E.R.; Schoenmakers, P.; Miller, N.; Eds.; Marcel Dekker: New York, 1998; vol. 78, pp. 365-411.
101. Kalish, H.; Phillips, T.M. Micro-HPLC Chromatography. In Second Edition of the Handbook of HPLC, 2nd ed.; Corradini, D.; Ed.; CRC Press-Taylor and Francis Group: Florida, In Press.
102. Wu, R.; Hu, L.; Wang, F.; Ye, M.; Zou, H. Recent development of monolithic stationary phases with emphasis on microscale chromatographic separation. J. Chromatogr. A, 2008, 1184(1-2), 369-392.
103. Saz, J. M.; Marina, M.L. Application of micro- and nano-HPLC to the determination and characterization of bioactive and biomarker peptides. J. Sep. Sci., 2008, 31(3), 446-458.
104. Timperman, A.T.; Aebersold, R. Peptide electroextraction for direct coupling of in-gel digests with capillary LC-MS/MS for protein identification and sequencing. Anal. Chem., 2000, 72(17), 4115-4121.
105. Madera, M.; Mechref, Y.; Klouckova, I.; Novotny, M.V. Semiautomated high-sensitivity profiling of human blood serum glycoproteins through lectin preconcentration and multidimensional chromatography/tandem mass spectrometry. J. Proteome Res., 2006, 5(9), 2348-2363.
106. Starkey, J.A.; Mechref, Y.; Muzikar, J.; McBride, W.J. Novotny, M.V. Determination of salsolinol and related catecholamines through on-line preconcentration and liquid chromatography/atmospheric pressure photoionization mass spectrometry. Anal. Chem., 2006, 78(10), 3342-3347.
107. Mitulovic, G.; Stingl, C.; Smoluch, M.; Swart, R.; Chervet, J.P.; Steinmacher, I.; Gerner, C.; Mechtler, K. Automated, on-line two-dimensional nano liquid chromatography tandem mass spectrometry for rapid analysis of complex protein digests. Proteomics, 2004, 4(9), 2545-2557.
108. Penrose, A.; Myers, P.; Bartle, K.; McCrossen, S. Development and assessment of a miniaturised centrifugal chromatograph for reversed-phase separations in micro-channels. Analyst, 2004, 129(8), 704-709.
109. Northrup, M.A.; Benett, B.; Hadley, D.; Landre, P.; Lehew, S.; Richards, J.; Stratton, P. A miniature analytical instrument for nucleic acids based on micromachined silicon reaction chambers. Anal. Chem., 1998, 70(5), 918-922.
110. Ebrahimzadeh, H.; Yamini, Y.; Sedighi, A.; Rouini, M. R. Determination of tramadol in human plasma and urine samples using liquid phase microextraction with back extraction combined with high performance liquid chromatography. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2008, 863(2), 229-234.
111. Kim, N. H.; Park, Y.; Jeong, E. S.; Kim, C. S.; Jeoung, M. K.; Kim, K. S.; Hong, S. H.; Son, J. K.; Hong, J. T.; Park, I. Y.; Moon, D. C. A liquid chromatographic method for the determination of histamine in immunoglobulin preparation using solid phase extraction and pre-column derivatization. Arch. Pharm. Res., 2007, 30(10), 1350-1357.
112. Hamase, K. Sensitive two-dimensional determination of small amounts of D-amino acids in mammals and the study on their functions. Chem. Pharm. Bull (Tokyo), 2007, 55(4), 503-510.
113. Dal Bo, L.; Mazzucchelli, P.; Fibbioli, M.; Marzo, A. Bioassay of safinamide in biological fluids of humans and various animal species. Arzneimittelforschung, 2006, 56(12), 814-819.
114. Fumagalli, M.; Dolcini, L.; Sala, A.; Stolk, J.; Fregonese, L.; Ferrari, F.; Viglio, S.; Luisetti, M.; Iadarola, P. Proteomic analysis of exhaled breath condensate from single patients with pulmonary emphysema associated to alpha(1)-antitrypsin deficiency. J. Proteomics, 2008, 71(2), 211-221.
115. Jmeian, Y.; El Rassi, Z. Micro-high-performance liquid chromatography platform for the depletion of high-abundance proteins and subsequent on-line concentration/capturing of medium and low-abundance proteins from serum. Application to profiling of protein expression in healthy and osteoarthritis sera by 2-D gel electrophoresis. Electrophoresis, 2008, 29(13), 2801-2811.
116. Gandhi, S.V.; Dhavale, N.D.; Jadhav, V.Y.; Sabnis, S.S. Spectrophotometric and reversed-phase high-performance liquid chromatographic methods for simultaneous determination of escitalopram oxalate and clonazepam in combined tablet dosage form. J. AOAC Int., 2008, 91(1), 33-38.
117. Gao, M.; Deng, C.; Yu, W.; Zhang, Y.; Yang, P.; Zhang, X. Large scale depletion of the high-abundance proteins and analysis of middle- and low-abundance proteins in human liver proteome by multidimensional liquid chromatography. Proteomics, 2008, 8(5), 939-947.
118. Suno, M.; Ono, T.; Iida, S.; Umetsu, N.; Ohtaki, K.; Yamada, T.; Awaya, T.; Satomi, M.; Tasaki, Y.; Shimizu, K.; Matsubara, K. Improved high-performance liquid chromatographic detection of paclitaxel in patient's plasma using solid-phase extraction, and semi-micro-bore C18 separation and UV detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2007, 860(1), 141-144.
119. Injac, R.; Djordjevic-Milic, V.; Srdjenovic, B. Thermostability testing and degradation profiles of doxycycline in bulk, tablets, and capsules by HPLC. J. Chromatogr. Sci., 2007, 45(9), 623-628.
120. Koidl, J.; Hodl, H.; Schmid, M.G.; Neubauer, B.; Konrad, M.; Petschauer, S.; Gubitz, G. Enantiorecognition of triiodothyronine and thyroxine enantiomers using different chiral selectors by HPLC and micro-HPLC. J. Biochem. Biophys. Methods, 2008, 70(6), 1254-1260.
121. Yanagihara, T.; Aoki, T.; Soeishi, Y.; Iwatsubo, T.; Kamimura, H. Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2007, 859(2), 241-245.
122. Gupta, M.; Kohli, K.; Kumar, D.; Gupta, Y. K. A reverse phase high performance liquid chromatography method for simultaneous estimation of melatonin, carbamazepine epoxide and carbamazepine simultaneously in serum. Indian J. Physiol. Pharmacol., 2006, 50(4), 427-430.
123. Musmade, P.; Subramanian, G.; Srinivasan, K. K. High-performance liquid chromatography and pharmacokinetics of aceclofenac in rats. Anal. Chim. Acta, 2007, 585(1), 103-109.
124. Liu, Y.; Nguyen, H.; Wang, S.; Yeh, J. High-throughput determination of OROS drug release rate profile using micro parallel liquid chromatography. J. Pharm. Biomed. Anal., 2007, 43(5), 1654-1659.
125. Glass, B. D.; Agatonovic-Kustrin, S.; Chen, Y. J.; Wisch, M. H. Optimization of a stability-indicating HPLC method for the simultaneous determination of rifampicin, isoniazid, and pyrazinamide in a fixed-dose combination using artificial neural networks. J. Chromatogr. Sci., 2007, 45(1), 38-44.
126. Ohwaki, Y.; Yamane, T.; Ishimatsu, T.; Wada, M.; Nakashima, K. Semi-micro column high-performance liquid chromatography with UV detection for quantification of aspirin and salicylic acid and its application to patients' sera administered with low-dose entericcoated aspirin. Biomed. Chromatogr., 2007, 21(3), 221-224.
127. Bakry, R.; Stoggl, W. M.; Hochleitner, E. O.; Stecher, G.; Huck, C. W.; Bonn, G. K. Silica particles encapsulated poly(styrene-divinylbenzene) monolithic stationary phases for micro-high performance liquid chromatography. J. Chromatogr. A, 2006, 1132(1-2), 183-189.
128. Kumihashi, M.; Ameno, K.; Shibayama, T.; Suga, K.; Miyauchi, H.; Jamal, M.; Wang, W.; Uekita, I.; Ijiri, I. Simultaneous determination of methamphetamine and its metabolite, amphetamine, in urine using a high performance liquid chromatography columns-witching method. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2007, 845(1), 180-183.
129. Legido-Quigley, C.; Smith, N. W. Short polystyrene monolith-fritted micro-liquid chromatography columns for rapid isocratic analysis of pharmaceuticals direct from plasma. Anal. Bioanal. Chem., 2006, 385(4), 686-691.
130. Koidl, J.; Hodl, H.; Schmid, M. G.; Konrad, M.; Petschauer, S.; Kostner, G. M.; Gubitz, G. Chiral separation of T3 enantiomers using stereoselective antibodies as a selector in micro-HPLC. J. Biochem. Biophys. Methods, 2006, 69(1-2), 33-42.
131. Guo, T.; Gu, J.; Soldin, O. P.; Singh, R. J.; Soldin, S. J. Rapid measurement of estrogens and their metabolites in human serum by liquid chromatography-tandem mass spectrometry without derivatization. Clin. Biochem., 2008, 41(9), 736-741.
132. Sundstrom, I.; Andren, P. E.; Westerlund, D. Method development for identification of ketobemidone metabolites in microdialysate samples by coupled-column capillary liquid chromatography-tandem mass spectrometry. J. Chromatogr. A, 2008, 1189(1-2), 503-513.
133. Chen, J.; Zhao, X.; Fritsche, J.; Yin, P.; Schmitt-Kopplin, P.; Wang, W.; Lu, X.; Haring, H. U.; Schleicher, E. D.; Lehmann, R.; Xu, G. Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information. Anal. Chem., 2008, 80(4), 1280-1289.
134. Tremblay, M.; Lessard, M. R.; Trepanier, C. A.; Nicole, P. C.; Nadeau, L.; Turcotte, G. Stability of norepinephrine infusions prepared in dextrose and normal saline solutions. Can. J. Anaesth., 2008, 55(3), 163-167.
135. Djukovic, D.; Appiah-Amponsah, E.; Shanaiah, N.; Gowda, G. A.; Henry, I.; Everly, M.; Tobias, B.; Raftery, D. Ibuprofen metabolite profiling using a combination of SPE/column-trapping and HPLC-micro-coil NMR. J. Pharm. Biomed. Anal., 2008, 47(2), 328-334.
136. Marcelin-Jimenez, G.; Garcia-Gonzalez, A.; Angeles-Moreno, A. P.; Contreras-Zavala, L.; Rivera, L.; Morales, M. Development of an ultra-performance liquid chromatography technique coupled with mass spectrometry for the measurement of tacrolimus in micro-samples of whole blood, and its application on a pharmacokiinetic trial. Arzneimittelforschung, 2007, 57(10), 659-664.
137. Kajiyama, S.; Harada, K.; Fukusaki, E.; Kobayashi, A. Single cell-based analysis of torenia petal pigments by a combination of ArF excimer laser micro sampling and nano-high performance liquid chromatography (HPLC)-mass spectrometry. J. Biosci. Bioeng., 2006, 102(6), 575-578.
138. Hsieh, Y.; Duncan, C. J.; Lee, S.; Liu, M. Comparison of fast liquid chromatography/tandem mass spectrometric methods for simultaneous determination of cladribine and clofarabine in mouse plasma. J. Pharm. Biomed. Anal., 2007, 44(2), 492-497.
139. Hazotte, A.; Libong, D.; Chaminade, P. High-temperature micro liquid chromatography for lipid molecular species analysis with evaporative light scattering detection. J. Chromatogr. A, 2007, 1140(1-2), 131-139.
140. Penrose, A.; Myers, P.; Bartle, K.; McCrossen, S. Development and assessment of a miniaturised centrifugal chromatograph for reversed-phase separations in micro-channels. Analyst, 2004, 129(8), 704-709.
141. Northrup, M. A.; Benett, B.; Hadley, D.; Landre, P.; Lehew, S.; Richards, J.; Stratton, P., A miniature analytical instrument for nucleic acids based on micromachined silicon reaction chambers. Anal. Chem., 1998, 70(5), 918-922.