Proteomic analysis of exhaled breath condensate from single patients with pulmonary emphysema associated to α1-antitrypsin deficiency

Journal of Proteomics

Volumn 71, Issue 2, 2008, Pages 211-221

  Fumagalli, Marco ^a   Dolcini, Lorenzo ^a   Sala, Alberto ^a   Stolk, Jan ^b   Fregonese, Laura ^b   Ferrari, Fabio ^a   Viglio, Simona ^a   Luisetti, Maurizio ^c   Iadarola, Paolo ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

1 antitrypsin deficiency; Cytokeratins; Cytokines; Exhaled breath condensate; Proteomics

Indexed keywords

ALPHA 1 ANTITRYPSIN; CYTOKERATIN; CYTOKINE;

ADULT; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; BREATH ANALYSIS; CAPILLARY ELECTROPHORESIS; CLINICAL ARTICLE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LUNG DISEASE; LUNG EMPHYSEMA; MALE; NUCLEOTIDE SEQUENCE; PEPTIDE ANALYSIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY;

ADULT; ALPHA 1-ANTITRYPSIN; BREATH TESTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOKINES; EXHALATION; FEMALE; HUMANS; KERATINS; MALE; PROTEOME; PROTEOMICS; PULMONARY EMPHYSEMA;

EID: 46249125357     PISSN: 18743919     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jprot.2008.03.002     Document Type: Article

References (42)

1. Montuschi P. Exhaled breath condensate analysis in patients with COPD. Clin Chim Acta 356 (2005) 22-34
2. Miekisch W., Schubert J.K., and Noeldge-Schomburg G.F. Diagnostic potential of breath analysis-focus on volatile organic compounds. Clin Chim Acta 347 (2004) 25-39
3. Phillips M., Herrera J., Krishnan S., Zain M., Greenberg J., and Cataneo R.N. Variation in volatile organic compounds in the breath of normal humans. J Chromatogr B 729 (1999) 75-88
4. Montuschi P., Collins J.V., Ciabattoni G., Lazzeri N., Corradi M., Kharitonov S.A., et al. Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med 162 (2000) 1175-1177
5. Kharitonov S.A., and Barnes P.J. Exhaled markers of inflammation. Curr Opin Allergy Clin Immunol 1 (2001) 217-224
6. Bucchioni E., Kharitonov S.A., Allegra L., and Barnes P.J. High levels of interleukin-6 in the exhaled breath condensate of patients with COPD. Respir Med 97 (2003) 1299-1302
7. Garey K.W., Neuhauser M.M., Robbins R.A., Danziger L.H., and Rubinstein I. Markers of inflammation in exhaled breath condensate of young healthy smokers. Chest 125 (2004) 22-26
8. Gessner C., Scheibe R., Wötzel M., Hammerschmidt S., Kuhn H., Engelmann L., et al. Exhaled breath condensate cytokine patterns in chronic obstructive pulmonary disease. Respir Med 99 (2005) 1229-1240
9. Carpagnano G.E., Kharitonov S.A., Resta O., Foschino-Barbaro M.P., Gramiccioni E., and Barnes P.J. 8-isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnoea after night and is reduced by continuous positive airway pressure therapy. Chest 124 (2003) 1386-1392
10. Montuschi P., Kharitonov S.A., Ciabattoni G., and Barnes P.J. Exhaled leukotrienes and prostaglandins in COPD. Thorax 58 (2003) 585-588
11. Mondino C., Ciabattoni G., Koch P., Pistelli R., Trové A., Barnes P.J., et al. Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children. J Allergy Clin Immunol 114 (2004) 761-767
12. Sack U., Scheibe R., Wötzel M., Hammerschmidt S., Kuhn H., Emmrich F., et al. Multiplex analysis of cytokines in exhaled breath condensate. Cytometry A 69 (2006) 169-172
13. Scheideler L., Manke H.G., Schwulera U., Inacker O., and Hämmerle H. Detection of nonvolatile macromolecules in breath. A possible diagnostic tool?. Am Rev Respir Dis 148 (1993) 778-784
14. Hunt J. Exhaled breath condensate: an evolving tool for non-invasive evaluation of lung disease. J Allergy Clin Immunol 110 (2002) 28-34
15. Schumann C., Triantafilou K., Krueger S., Hombach V., Triantafilou M., Becher G., et al. Detection of erythropoietin in exhaled breath condensate of nonhypoxic subjects using a multiplex bead array. Mediators Inflamm 2006 (2006) 18061
16. Bloemen K., Lissens G., Desager K., and Schoeters G. Determinants of variability of protein content, volume and pH of exhaled breath condensate. Respir Med 101 (2007) 1331-1337
17. Mukhopadhyay R. Don't waste your breath. Researchers are developing breath tests for diagnosing diseases, but how well do they work?. Anal Chem 76 (2004) 273-276
18. Pleil J.D., and Lindstrom A.B. Exhaled human breath measurement method for assessing exposure to halogenated volatile organic compounds. Clin Chem 43 (1997) 723-730
19. Manolis A. The diagnostic potential of breath analysis. Clin Chem 29 (1983) 5-15
20. Jackson A.S., Sandrini A., Campbell C., Chow S., Thomas P.S., and Yates D.H. Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage. Am J Respir Crit Care Med 175 (2007) 222-227
21. Cao W., and Duan Y. Breath analysis: potential for clinical diagnosis and exposure assessment. Clin Chem 52 (2006) 800-811
22. Kharitonov S.A., and Barnes P.J. Exhaled markers of pulmonary disease. Am J Respir Crit Care Med 163 (2001) 1693-1722
23. Kharitonov S.A., and Barnes P.J. Effects of corticosteroid of non-invasive biomarkers of inflammation in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 1 (2004) 191-199
24. Leung T.F., Wong G.W., Ko F.W., Li C.Y., Yung E., Lam C.W., et al. Analysis of growth factors and inflammatory cytokines in exhaled breath condensate from asthmatic children. Int Arch Allergy Immunol 137 (2005) 66-72
25. Ko F.W.S., Lau C.Y.K., Leung T.F., Wong G.W.K., Lam C.W.K., and Hui D.S.C. Exhaled breath condensate levels of 8-isoprostane, growth related oncogene a and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary disease. Respir Med 100 (2006) 630-638
26. Hanazawa T., Kharitonov S.A., and Barnes P.J. Increased nitrotyrosine in exhaled breath condensate of patients with asthma. Am J Respir Crit Care Med 162 (2000) 1273-1276
27. Montuschi P., Kharitonov S.A., Carpagnano E., Culpitt S.V., Russel R., Collins J.V., et al. Exhaled prostaglandin E2: a new biomarker of airway inflammation in COPD. Am J Respir Crit Care Med 161 (2000) 821
28. Montuschi P., and Barnes P.J. Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol 109 (2002) 615-620
29. Montuschi P., Kharitonov S.A., Ciabattoni G., and Barnes P.J. Exhaled leukotrienes and prostaglandins in COPD. Thorax 58 (2003) 585-588
30. Mutlu G.M., Garey K.W., Robbins R.A., Danziger L.H., and Rubinstein I. Collection and analysis of exhaled breath condensate in humans. Am J Respir Crit Care Med 164 (2001) 731-737
31. Griese M., Noss J., and von Bredow C. Protein pattern of exhaled breath condensate and saliva. Proteomics 2 (2002) 690-696
32. Gianazza E., Allegra L., Bucchioni E., Eberini I., Puglisi L., Blasi F., et al. Increased keratin content detected by proteomic analysis of exhaled breath condensate from healthy persons who smoke. Am J Med 117 (2004) 51-54
33. Gessner C., Dihazi H., Brettschneider S., Hammerschmidt S., Kuhn H., Eschrich K., et al. Presence of cytokeratins in exhaled breath condensate of mechanical ventilated patients. Respir Med 102 (2008) 299-306
34. Hoffmann H., Tabaksblat L., Enghild J., and Dahl R. Keratin detected in exhaled breath condensate is an environmental contaminant. Eur Respir J 26 (2005) 231S
35. Hoffmann H., Tabaksblat L., Enghild J., and Dahl R. Human skin keratins are the major proteins in exhaled breath condensate. Eur Respir J 31 (2008) 1-5
36. Hochstrasser D.F., Patchornik A., and Merril C.R. Development of polyacrylamide gels that improve the separation of proteins and their detection by silver staining. Anal Biochem 173 (1988) 412-423
37. Effros R.M., Hoagland K.W., Bosbous M., Castillo D., Foss B., Dunning M., et al. Dilution of respiratory solute in exhaled condensate. Am J Respir Crit Care Med 165 (2002) 663-669
38. Blobel G.A., Moll R., Franke W.W., and Vogt-Moykopf I. Cytokeratins in normal lung and lung carcinomas. I. Adenocarcinomas, squamous cell carcinomas and cultured cell lines. Virchows Arch B Cell Pathol Incl Mol Pathol 45 (1984) 407-429
39. Bowden P.E. Keratins and other epidermal proteins. In: Priestly G. (Ed). Molecular Aspects of Dermatology (1993), Wiley, New York 19-54
40. Fisseler-Eckhoff A., Erfkamp S., and Müller K.M. Cytokeratin expression in preneoplastic lesions and early squamous cell carcinoma of the bronchi. Pathol Res Pract 192 (1996) 552-559
41. Nakamura H., Abe S., Shibata Y., Yuki H., Suzuki H., Saito H., et al. Elevated levels of cytokeratin 19 in the bronchoalveolar lavage fluid of patients with chronic airway inflammatory diseases-a specific marker for bronchial epithelial injury. Am J Respir Crit Care Med 155 (1997) 1217-1221
42. Rosias P.P., Robroeks C.M., Kester A., den Hartog G.J., Wodzig W.K., Rijkers G.T., et al. Biomarker reproducibility in exhaled breath condensate collected with different condensers. Eur Respir J 31 5 (2008) E-pub ahead of print